ID D3P025_AZOS1 Unreviewed; 300 AA.
AC D3P025;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 24-JAN-2024, entry version 70.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:BAI74004.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:BAI74004.1};
GN Name=garR {ECO:0000313|EMBL:BAI74004.1};
GN OrderedLocusNames=AZL_a04730 {ECO:0000313|EMBL:BAI74004.1};
OS Azospirillum sp. (strain B510).
OG Plasmid pAB510a {ECO:0000313|EMBL:BAI74004.1,
OG ECO:0000313|Proteomes:UP000002040}.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Azospirillaceae; Azospirillum.
OX NCBI_TaxID=137722 {ECO:0000313|EMBL:BAI74004.1, ECO:0000313|Proteomes:UP000002040};
RN [1] {ECO:0000313|EMBL:BAI74004.1, ECO:0000313|Proteomes:UP000002040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B510 {ECO:0000313|EMBL:BAI74004.1,
RC ECO:0000313|Proteomes:UP000002040};
RC PLASMID=pAB510a {ECO:0000313|EMBL:BAI74004.1};
RX PubMed=20047946; DOI=10.1093/dnares/dsp026;
RA Kaneko T., Minamisawa K., Isawa T., Nakatsukasa H., Mitsui H.,
RA Kawaharada Y., Nakamura Y., Watanabe A., Kawashima K., Ono A., Shimizu Y.,
RA Takahashi C., Minami C., Fujishiro T., Kohara M., Katoh M., Nakazaki N.,
RA Nakayama S., Yamada M., Tabata S., Sato S.;
RT "Complete genomic structure of the cultivated rice endophyte Azospirillum
RT sp. B510.";
RL DNA Res. 17:37-50(2010).
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; AP010947; BAI74004.1; -; Genomic_DNA.
DR RefSeq; WP_012975900.1; NC_013855.1.
DR AlphaFoldDB; D3P025; -.
DR KEGG; azl:AZL_a04730; -.
DR HOGENOM; CLU_035117_1_0_5; -.
DR OrthoDB; 9812907at2; -.
DR Proteomes; UP000002040; Plasmid pAB510a.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006398; Tartro_sem_red.
DR NCBIfam; TIGR01505; tartro_sem_red; 1.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:BAI74004.1};
KW Plasmid {ECO:0000313|EMBL:BAI74004.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002040}.
FT DOMAIN 3..165
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 168..288
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 174
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 300 AA; 30845 MW; EA5EFFF529CD9214 CRC64;
MSKLGFIGLG IMGTPMAGHL QAAGHRLYVH TVGGVPEVLV AGGAVVCGSG KEVAEQAEIV
FIMVPDTPDV EKVLFGVGGV AEGLGAGKGA GKIVVDMSSI SPVATKDFAQ RVNELGCDYL
DAPVSGGEVG AKAASLTIMV GGPDKAFETV KPLFELMGKN ITLVGGNGDG QTTKVANQII
VALTIEAVGE ALLLAAKAGA DPAKVRQALM GGFANSRILE VHGERMVKRS FDPGFRIELH
QKDLNLALAT ARSLGVSLPN TATAQELFNA CAANGGRAWD HSAMVRALEM LANFEIGQTV
//
