ID D3PQL8_MEIRD Unreviewed; 222 AA.
AC D3PQL8;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Futalosine hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
DE Short=FL hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
DE EC=3.2.2.26 {ECO:0000256|HAMAP-Rule:MF_00991};
DE AltName: Full=Futalosine nucleosidase {ECO:0000256|HAMAP-Rule:MF_00991};
DE AltName: Full=Menaquinone biosynthetic enzyme MqnB {ECO:0000256|HAMAP-Rule:MF_00991};
GN Name=mqnB {ECO:0000256|HAMAP-Rule:MF_00991};
GN OrderedLocusNames=Mrub_0986 {ECO:0000313|EMBL:ADD27751.1};
GN ORFNames=K649_04570 {ECO:0000313|EMBL:AGK04216.1};
OS Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus
OS ruber).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Meiothermus.
OX NCBI_TaxID=504728 {ECO:0000313|EMBL:AGK04216.1, ECO:0000313|Proteomes:UP000013026};
RN [1] {ECO:0000313|EMBL:ADD27751.1, ECO:0000313|Proteomes:UP000006655}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35948 / DSM 1279 / VKM B-1258 / 21
RC {ECO:0000313|Proteomes:UP000006655}, and DSM 1279
RC {ECO:0000313|EMBL:ADD27751.1};
RX PubMed=21304689; DOI=10.4056/sigs.1032748;
RA Tindall B.J., Sikorski J., Lucas S., Goltsman E., Copeland A.,
RA Glavina Del Rio T., Nolan M., Tice H., Cheng J.F., Han C., Pitluck S.,
RA Liolios K., Ivanova N., Mavromatis K., Ovchinnikova G., Pati A.,
RA Fahnrich R., Goodwin L., Chen A., Palaniappan K., Land M., Hauser L.,
RA Chang Y.J., Jeffries C.D., Rohde M., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Lapidus A.;
RT "Complete genome sequence of Meiothermus ruber type strain (21).";
RL Stand. Genomic Sci. 3:26-36(2010).
RN [2] {ECO:0000313|EMBL:AGK04216.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 1279 {ECO:0000313|EMBL:AGK04216.1};
RA Klammer A., Drake J., Heiner C., Clum A., Copeland A., Huddleston J.,
RA Eichler E., Turner S.W.;
RT "Non-Hybrid, Finished Microbial Genome Assemblies from Long-Read SMRT
RT Sequencing Data.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AGK04216.1, ECO:0000313|Proteomes:UP000013026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35948 / DSM 1279 / VKM B-1258 / 21
RC {ECO:0000313|Proteomes:UP000013026}, and DSM 1279
RC {ECO:0000313|EMBL:AGK04216.1};
RA Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine
CC futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of
CC menaquinone (MK, vitamin K2). {ECO:0000256|HAMAP-Rule:MF_00991}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=futalosine + H2O = dehypoxanthine futalosine + hypoxanthine;
CC Xref=Rhea:RHEA:25904, ChEBI:CHEBI:15377, ChEBI:CHEBI:17368,
CC ChEBI:CHEBI:58863, ChEBI:CHEBI:58864; EC=3.2.2.26;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00991};
CC -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC {ECO:0000256|HAMAP-Rule:MF_00991}.
CC -!- SIMILARITY: Belongs to the PNP/UDP phosphorylase family. Futalosine
CC hydrolase subfamily. {ECO:0000256|HAMAP-Rule:MF_00991}.
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DR EMBL; CP001743; ADD27751.1; -; Genomic_DNA.
DR EMBL; CP005385; AGK04216.1; -; Genomic_DNA.
DR RefSeq; WP_013013270.1; NC_021081.1.
DR AlphaFoldDB; D3PQL8; -.
DR STRING; 504728.K649_04570; -.
DR KEGG; mrb:Mrub_0986; -.
DR KEGG; mre:K649_04570; -.
DR PATRIC; fig|504728.9.peg.944; -.
DR eggNOG; COG0775; Bacteria.
DR OrthoDB; 9788270at2; -.
DR UniPathway; UPA00079; -.
DR Proteomes; UP000006655; Chromosome.
DR Proteomes; UP000013026; Chromosome.
DR GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:UniProtKB-UniRule.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
DR CDD; cd17766; futalosine_nucleosidase_MqnB; 1.
DR Gene3D; 3.40.50.1580; Nucleoside phosphorylase domain; 1.
DR HAMAP; MF_00991; MqnB; 1.
DR InterPro; IPR019963; FL_hydrolase_MqnB.
DR InterPro; IPR000845; Nucleoside_phosphorylase_d.
DR InterPro; IPR035994; Nucleoside_phosphorylase_sf.
DR NCBIfam; TIGR03664; fut_nucase; 1.
DR PANTHER; PTHR46832; 5'-METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE; 1.
DR PANTHER; PTHR46832:SF2; FUTALOSINE HYDROLASE; 1.
DR Pfam; PF01048; PNP_UDP_1; 1.
DR SUPFAM; SSF53167; Purine and uridine phosphorylases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_00991};
KW Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_00991}.
FT DOMAIN 36..220
FT /note="Nucleoside phosphorylase"
FT /evidence="ECO:0000259|Pfam:PF01048"
SQ SEQUENCE 222 AA; 24357 MW; B4F36316561F7C0E CRC64;
MPTLPLLLLS PTRLEAPFLK GQKFDFHGRA GLRGAGWVWL ECGIGKVNTA ATLAAFVQRR
RFERVLLFGI AGAYADSGLQ LGDCALAERE IQADLGVRDG GLKGLGFPSL VVASRPYHNR
FPLDKAFTDE LKSKLGLPGK QFLTRDLVSE NPTEAHQLAR KWEADLENME GAAFAQTCLW
LGLAGAELRA VSNMAGVRDK AQWRIRQAVE ALEHHILRII GS
//
