ID D3PRZ5_MEIRD Unreviewed; 763 AA.
AC D3PRZ5;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase NAD-binding protein {ECO:0000313|EMBL:AGK06333.1};
GN OrderedLocusNames=Mrub_1466 {ECO:0000313|EMBL:ADD28228.1};
GN ORFNames=K649_15235 {ECO:0000313|EMBL:AGK06333.1};
OS Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM B-1258 / 21) (Thermus
OS ruber).
OC Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Meiothermus.
OX NCBI_TaxID=504728 {ECO:0000313|EMBL:AGK06333.1, ECO:0000313|Proteomes:UP000013026};
RN [1] {ECO:0000313|EMBL:ADD28228.1, ECO:0000313|Proteomes:UP000006655}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35948 / DSM 1279 / VKM B-1258 / 21
RC {ECO:0000313|Proteomes:UP000006655}, and DSM 1279
RC {ECO:0000313|EMBL:ADD28228.1};
RX PubMed=21304689; DOI=10.4056/sigs.1032748;
RA Tindall B.J., Sikorski J., Lucas S., Goltsman E., Copeland A.,
RA Glavina Del Rio T., Nolan M., Tice H., Cheng J.F., Han C., Pitluck S.,
RA Liolios K., Ivanova N., Mavromatis K., Ovchinnikova G., Pati A.,
RA Fahnrich R., Goodwin L., Chen A., Palaniappan K., Land M., Hauser L.,
RA Chang Y.J., Jeffries C.D., Rohde M., Goker M., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Lapidus A.;
RT "Complete genome sequence of Meiothermus ruber type strain (21).";
RL Stand. Genomic Sci. 3:26-36(2010).
RN [2] {ECO:0000313|EMBL:AGK06333.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 1279 {ECO:0000313|EMBL:AGK06333.1};
RA Klammer A., Drake J., Heiner C., Clum A., Copeland A., Huddleston J.,
RA Eichler E., Turner S.W.;
RT "Non-Hybrid, Finished Microbial Genome Assemblies from Long-Read SMRT
RT Sequencing Data.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AGK06333.1, ECO:0000313|Proteomes:UP000013026}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35948 / DSM 1279 / VKM B-1258 / 21
RC {ECO:0000313|Proteomes:UP000013026}, and DSM 1279
RC {ECO:0000313|EMBL:AGK06333.1};
RA Chin J., Alexander D.H., Marks P., Korlach J., Clum A., Copeland A.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
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DR EMBL; CP001743; ADD28228.1; -; Genomic_DNA.
DR EMBL; CP005385; AGK06333.1; -; Genomic_DNA.
DR RefSeq; WP_013013730.1; NC_021081.1.
DR AlphaFoldDB; D3PRZ5; -.
DR STRING; 504728.K649_15235; -.
DR KEGG; mrb:Mrub_1466; -.
DR KEGG; mre:K649_15235; -.
DR PATRIC; fig|504728.9.peg.3130; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR OrthoDB; 9815331at2; -.
DR Proteomes; UP000006655; Chromosome.
DR Proteomes; UP000013026; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..763
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038283696"
FT DOMAIN 5..184
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 187..282
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 477..605
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 763 AA; 83710 MW; 66D41B58281F3F47 CRC64;
MRIKKIGVVG SGTMGGAIAA LAASAGVPVV MLDIPGQEDK LELVKKGLER QLKSKPASFM
DKSRASLIEL GTTDELEKLK DCDWIVEVII EKPEPKQALF ARIEALGTQA IVSSNTSGIP
MKTLLEGRGE AFRKRFLGTH FFAPVRYLHL LELIPTPETD PAVLETMRRF GERILGKGTV
ICKDAPGFIA NRLGVFGMAQ AMRLMMSEGL TIDEVDALTG PLVGRPKSAT FRTGDISGLD
VLKLVSTELS HTTGEDFRMP DWVESLIQQG HLGEKTGAGF YKKVGKDIYT YDYTSGEYKP
QQKLRLDEIA AIKDLPLNER LKRVGDLPGK YGAFARKLFL YNAHYALEKA QEIAYDIVSV
DRALEWGFAW EQGPFKNMDA VGLDYLRKGF AELGLPEPEL LKKAQGSFYK DGHYLGFDGQ
YHPIPAEEGV IRLQTVKQAG KTLLEGKEYA LLDLGDGVAL FENRAKMGTW GDGSISGLHK
ALDWVEANGY AGLVIGHEDP RTFSAGANLA LVLMAAQEGA WDDLELATRR FQQTSMRLRR
SPFPVVAAPF GLTLGGGAEF SLHSSAIQAH AELYMGLVET GVGLLPGGGG TKEMLFRFTQ
ELAAYGPEID LFEGVKRAFQ MIMLAQTSTS ALEARNMGFL RPSDGISMNR DRLIADAKRR
VLFMAPDFVP QPPMKVRALG KEALGNLHYA LWQFQEAKQA SEHDVVVGKA VAYVLCGGDG
PAREVTEQDI LDLEREGFLK LLGTKKTQER IAHTLKTGKP LRN
//
