ID D3QAI2_STANL Unreviewed; 513 AA.
AC D3QAI2;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=histidine ammonia-lyase {ECO:0000256|ARBA:ARBA00012994};
DE EC=4.3.1.3 {ECO:0000256|ARBA:ARBA00012994};
GN OrderedLocusNames=Snas_3094 {ECO:0000313|EMBL:ADD42765.1};
OS Stackebrandtia nassauensis (strain DSM 44728 / CIP 108903 / NRRL B-16338 /
OS NBRC 102104 / LLR-40K-21).
OC Bacteria; Actinomycetota; Actinomycetes; Glycomycetales; Glycomycetaceae;
OC Stackebrandtia.
OX NCBI_TaxID=446470 {ECO:0000313|EMBL:ADD42765.1, ECO:0000313|Proteomes:UP000000844};
RN [1] {ECO:0000313|EMBL:ADD42765.1, ECO:0000313|Proteomes:UP000000844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44728 / CIP 108903 / NRRL B-16338 / NBRC 102104 /
RC LLR-40K-21 {ECO:0000313|Proteomes:UP000000844};
RX PubMed=21304662; DOI=10.4056/sigs.47643;
RA Munk C., Lapidus A., Copeland A., Jando M., Mayilraj S.,
RA Glavina Del Rio T., Nolan M., Chen F., Lucas S., Tice H., Cheng J.F.,
RA Han C., Detter J.C., Bruce D., Goodwin L., Chain P., Pitluck S., Goker M.,
RA Ovchinikova G., Pati A., Ivanova N., Mavromatis K., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Stackebrandtia nassauensis type strain (LLR-
RT 40K-21).";
RL Stand. Genomic Sci. 1:292-299(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232,
CC ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000171};
CC -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00005113}.
CC -!- SIMILARITY: Belongs to the PAL/histidase family.
CC {ECO:0000256|RuleBase:RU003954}.
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DR EMBL; CP001778; ADD42765.1; -; Genomic_DNA.
DR RefSeq; WP_013018336.1; NC_013947.1.
DR AlphaFoldDB; D3QAI2; -.
DR STRING; 446470.Snas_3094; -.
DR KEGG; sna:Snas_3094; -.
DR eggNOG; COG2986; Bacteria.
DR HOGENOM; CLU_014801_4_0_11; -.
DR OrthoDB; 9806955at2; -.
DR UniPathway; UPA00379; UER00549.
DR Proteomes; UP000000844; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR005921; HutH.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR01225; hutH; 1.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR Pfam; PF00221; Lyase_aromatic; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
PE 3: Inferred from homology;
KW Histidine metabolism {ECO:0000256|ARBA:ARBA00022808};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU003954};
KW Reference proteome {ECO:0000313|Proteomes:UP000000844}.
SQ SEQUENCE 513 AA; 54272 MW; BD9D73C8BBFAF578 CRC64;
MRDLLLTGDG YSIEDVHAVA HRRARVRPGP GLAERMASAR AVVTEAVRRK DVVYGVTTGF
GALADTTIGA DDLAKLQVGI VRSHAAAVGT PLSDPIVRSL LLLRARTLSA GYSGVRPELP
LFFLTLLEHD LLPVIPEKGS VGASGDLAQL AHLALPVIGE GRLRAPGDPV AGRPAAEVLA
EHDITPLVLD PKEGLSLING TEPMQAVLAL AIMEAEALCK IADIACAMSV EALYGTDRAY
DPRVQVIRPH PGQLDSAANL RDLLDGSPLL ASHRDSDHAV QDSYALRCAP QVHGSSRDLI
THCRNVLSIE LKSIVDNPVV VRGPGGDGFE VMSTGNFHGQ PLAFSADALA MASAELGSIA
ERRVYRMLDP ATSRGLPPFL APDAGTNSGF MLAQYTAASL VSENKVLCHP AGVDSIVTSG
NQEDHVSMGW HAVRKAREVI DNVRSVLAIE LLCAAQGLDL RGDVAKPSPA TGAVLERVRQ
DVAAMPVDRE LAPQIEAVRD MLDDLIDVAG DLR
//
