ID D3R271_MAGIU Unreviewed; 727 AA.
AC D3R271;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN OrderedLocusNames=HMPREF0868_0973 {ECO:0000313|EMBL:ADC90892.1};
OS Mageeibacillus indolicus (strain UPII9-5) (Clostridiales genomosp. BVAB3
OS (strain UPII9-5)).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Mageeibacillus.
OX NCBI_TaxID=699246 {ECO:0000313|EMBL:ADC90892.1, ECO:0000313|Proteomes:UP000008234};
RN [1] {ECO:0000313|Proteomes:UP000008234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UPII9-5 {ECO:0000313|Proteomes:UP000008234};
RA Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RT "Sequence of Clostridiales genomosp. BVAB3 str. UPII9-5.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
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DR EMBL; CP001850; ADC90892.1; -; Genomic_DNA.
DR RefSeq; WP_012993334.1; NC_013895.2.
DR AlphaFoldDB; D3R271; -.
DR STRING; 699246.HMPREF0868_0973; -.
DR KEGG; clo:HMPREF0868_0973; -.
DR eggNOG; COG0188; Bacteria.
DR HOGENOM; CLU_002977_9_0_9; -.
DR OrthoDB; 9806486at2; -.
DR Proteomes; UP000008234; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 1.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR PANTHER; PTHR43493:SF1; DNA TOPOISOMERASE 4 SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 3.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ADC90892.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008234};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 10..458
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 430..457
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 727 AA; 82098 MW; 6BFFB507A7A74E8E CRC64;
MQKVKHTVVE KISDTLEKNY MPYAMSVIVS RAIPEIDGFK PSHRKLLYTM YKMGLLSGSR
TKSANVVGQT MKLNPHGDAA IYETMVRLTR GNASLLHPYV DSKGNFGKQY SRDMQFAASR
YTEVKLDKIC TELFRAIDKD VVTFTPNYDA TMQEPTLLPA TFPSVLVNAN QGIAVGMASN
ICPFNLREVC SATIAYIKNP DCVIEKYIKG PDFPGGGEFI VDREELAKVF DSGRGTLRLR
ARYRVDLKNR LIEIYEIPYS TTVEAVLDNL AELVKAGKAK EISDVRDETD LNGLKLTIEL
KRAAEPEALM NRLFKQTSLQ ANFACNFNVL IDGRPRVLGV KQLIGEWLNF RRTCVRRETA
FDLQEKQAKL HLLEGLNTIM LDIDKAIRII RETENETDVI PNLCRGFAID AVQAEYIAEI
KLRNLNREYL LKRTADRSEL TEEIAQLQNR LASTSLLDAE IIRTLQQVAE KYGQDRRTVL
IDAGEITEIT GEDLIEDYRL KYFLTAHGYL KKLPLTSLRS AGELKIKDED EIISEIEAGN
RDEIMVFTDQ ANVYKISGHE IKDCKPSELG EYLPGLLDFA PEEKVIYLHV PGEYVGDFMF
AFANGKVARV PVSAYKTKTK RRKLVAAYSD KSPLVGIEFA PENKSYVLIS NLSKVLIFDS
EQIPAKVTRN NQGVQVMSAK RNSVVNKFST PEAAGIQDSP YYRTKNLPAI GYYLKEDMVK
NRQMTIS
//
