ID D3S982_THISK Unreviewed; 758 AA.
AC D3S982;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Diguanylate cyclase with PAS/PAC sensor {ECO:0000313|EMBL:ADC71587.1};
GN OrderedLocusNames=TK90_1075 {ECO:0000313|EMBL:ADC71587.1};
OS Thioalkalivibrio sp. (strain K90mix).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Thioalkalivibrio.
OX NCBI_TaxID=396595 {ECO:0000313|EMBL:ADC71587.1, ECO:0000313|Proteomes:UP000009099};
RN [1] {ECO:0000313|Proteomes:UP000009099}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K90mix {ECO:0000313|Proteomes:UP000009099};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Foster B., Sun H., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Ivanova N., Sorokin D.Y., Muyzer G., Woyke T.;
RT "Complete sequence of chromosome of Thioalkalivibrio sp. K90mix.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADC71587.1, ECO:0000313|Proteomes:UP000009099}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K90mix {ECO:0000313|EMBL:ADC71587.1,
RC ECO:0000313|Proteomes:UP000009099};
RX PubMed=22675584; DOI=10.4056/sigs.2315092;
RA Muyzer G., Sorokin D.Y., Mavromatis K., Lapidus A., Foster B., Sun H.,
RA Ivanova N., Pati A., D'haeseleer P., Woyke T., Kyrpides N.C.;
RT "Complete genome sequence of Thioalkalivibrio sp. K90mix.";
RL Stand. Genomic Sci. 5:341-355(2011).
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DR EMBL; CP001905; ADC71587.1; -; Genomic_DNA.
DR RefSeq; WP_012982481.1; NC_013889.1.
DR AlphaFoldDB; D3S982; -.
DR STRING; 396595.TK90_1075; -.
DR KEGG; tkm:TK90_1075; -.
DR eggNOG; COG2199; Bacteria.
DR eggNOG; COG3452; Bacteria.
DR HOGENOM; CLU_021245_0_0_6; -.
DR OrthoDB; 9812260at2; -.
DR Proteomes; UP000009099; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:UniProt.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.30.450.350; CHASE domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR006189; CHASE_dom.
DR InterPro; IPR042240; CHASE_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR46663; DIGUANYLATE CYCLASE DGCT-RELATED; 1.
DR PANTHER; PTHR46663:SF2; GGDEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03924; CHASE; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08448; PAS_4; 1.
DR SMART; SM01079; CHASE; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50839; CHASE; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..275
FT /note="CHASE"
FT /evidence="ECO:0000259|PROSITE:PS50839"
FT DOMAIN 608..746
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 84207 MW; EBB9B65474296475 CRC64;
MDDSTHTRTE APDDAPRHEG RDSHSTAGPF VLGLAAALVF LGLFLLIDRA WKIELEDRQS
AAVAGELASL RTQVESLING LVHSTIGLAA YAYVHPDLES DEFERVAERI YRGHEDLVIS
LTLARGPIIE FVYPLEGNED VVGLNLATHP EQADSFRRVL NEREVVVAGP WPLVQGGYGL
LVRAPVDTDP APDGPSHLVI DEHANQLSIS SIALDFEALL ERAGIGEQRG TLLLALRGRD
GVGEAGPLFY NPHGLDEEAS YRHRIRFPGG EWQLLADVDP THRGTDRPMA WWALGFVGAL
AVGGYTYRVG TGLQARRRDL DRYRGLVNRL EDPTLVVSGR RILWANPAFV RMLGQQPPVN
TVLAQLDLVH PDDLDRLPPN LDFTDTPAET HGREVRICVS QGGCRFFLLR WVPVDWEQGR
AWLLTFVDVN ENRLLFDALT AARDLQDAMF EAIPGYAFVV DSEGTVRHVF GEACHRQEMA
PALLGDTLDQ LFPSDVAANF LEMVNRAIDE GTLQTNEYRL DVDLLKRLGI PEHETGARWF
EARIRPLARA INGLPAVVWH ALDVTDRREL EVKLKTMAWE DPLTGMANRA AMDRAFPRLA
ARAERQGGRL ALLFIDLDHF KPVNDRYGHA VGDQLLRRVA ERLKSHLRPD DVLVRLGGDE
FIVLTAPLDE REEGLHLAQR VQQDLNNTFE VHTGPGEFVE LKITSSIGVA FYPDVGRHLS
DLMVAADRAM YQVKAQGHND VGLAGDAPHN DGRSTPRA
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