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Database: UniProt
Entry: D3SN23_THEAH
LinkDB: D3SN23_THEAH
Original site: D3SN23_THEAH 
ID   D3SN23_THEAH            Unreviewed;       138 AA.
AC   D3SN23;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   24-JAN-2024, entry version 66.
DE   RecName: Full=Putative nickel-responsive regulator {ECO:0000256|HAMAP-Rule:MF_00476};
GN   OrderedLocusNames=Thal_1524 {ECO:0000313|EMBL:ADC90153.1};
OS   Thermocrinis albus (strain DSM 14484 / JCM 11386 / HI 11/12).
OC   Bacteria; Aquificota; Aquificae; Aquificales; Aquificaceae; Thermocrinis.
OX   NCBI_TaxID=638303 {ECO:0000313|EMBL:ADC90153.1, ECO:0000313|Proteomes:UP000002043};
RN   [1] {ECO:0000313|Proteomes:UP000002043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14484 / JCM 11386 / HI 11/12
RC   {ECO:0000313|Proteomes:UP000002043};
RX   DOI=10.4056/sigs.761490;
RA   Wirth R., Sikorski J., Brambilla E., Misra M., Lapidus A., Copeland A.,
RA   Nolan M., Lucas S., Chen F., Tice H., Cheng J.F., Han C., Detter J.C.,
RA   Tapia R., Bruce D., Goodwin L., Pitluck S., Pati A., Anderson I.,
RA   Ivanova N., Mavromatis K., Mikhailova N., Chen A., Palaniappan K.,
RA   Bilek Y., Hader T., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA   Tindall B.J., Rohde M., Goker M., Bristow J., Eisen J.A., Markowitz V.,
RA   Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Thermocrinis albus type strain (HI 11/12T).";
RL   Stand. Genomic Sci. 2:194-202(2010).
CC   -!- FUNCTION: Transcriptional regulator. {ECO:0000256|HAMAP-Rule:MF_00476}.
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00476};
CC       Note=Binds 1 nickel ion per subunit. {ECO:0000256|HAMAP-Rule:MF_00476};
CC   -!- SIMILARITY: Belongs to the transcriptional regulatory CopG/NikR family.
CC       {ECO:0000256|ARBA:ARBA00008478, ECO:0000256|HAMAP-Rule:MF_00476}.
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DR   EMBL; CP001931; ADC90153.1; -; Genomic_DNA.
DR   RefSeq; WP_012992559.1; NC_013894.1.
DR   AlphaFoldDB; D3SN23; -.
DR   STRING; 638303.Thal_1524; -.
DR   KEGG; tal:Thal_1524; -.
DR   eggNOG; COG0864; Bacteria.
DR   HOGENOM; CLU_113319_1_0_0; -.
DR   OMA; AHNCLET; -.
DR   OrthoDB; 9806294at2; -.
DR   Proteomes; UP000002043; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016151; F:nickel cation binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010045; P:response to nickel cation; IEA:InterPro.
DR   CDD; cd22231; RHH_NikR_HicB-like; 1.
DR   Gene3D; 3.30.70.1150; ACT-like. Chain A, domain 2; 1.
DR   Gene3D; 1.10.1220.10; Met repressor-like; 1.
DR   HAMAP; MF_00476; NikR; 1.
DR   InterPro; IPR027271; Acetolactate_synth/TF_NikR_C.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR002145; CopG.
DR   InterPro; IPR022988; Ni_resp_reg_NikR.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   InterPro; IPR014864; TF_NikR_Ni-bd_C.
DR   PANTHER; PTHR34719; NICKEL-RESPONSIVE REGULATOR; 1.
DR   PANTHER; PTHR34719:SF2; NICKEL-RESPONSIVE REGULATOR; 1.
DR   Pfam; PF08753; NikR_C; 1.
DR   Pfam; PF01402; RHH_1; 1.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF47598; Ribbon-helix-helix; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW   Rule:MF_00476};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00476};
KW   Nickel {ECO:0000256|ARBA:ARBA00022596, ECO:0000256|HAMAP-Rule:MF_00476};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002043};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW   Rule:MF_00476};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW   Rule:MF_00476}.
FT   DOMAIN          10..44
FT                   /note="Ribbon-helix-helix protein CopG"
FT                   /evidence="ECO:0000259|Pfam:PF01402"
FT   DOMAIN          57..131
FT                   /note="Transcription factor NikR nickel binding C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08753"
FT   BINDING         80
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
FT   BINDING         91
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
FT   BINDING         93
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
FT   BINDING         99
FT                   /ligand="Ni(2+)"
FT                   /ligand_id="ChEBI:CHEBI:49786"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00476"
SQ   SEQUENCE   138 AA;  16157 MW;  39FB687BC3182367 CRC64;
     MREKYVRFCV SLPKDLLEEL DRRTVLRGYS SRSELVRDLI REMLIEDMWE REEEDVVGVL
     TIVYDHHDIR LVSRMLDVQH KYHVNVLCNT HVHLDHRNCL ETMIIKGKAS QIEGLSTQLA
     GMRGVKFAKL VKAGKPEK
//
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