ID D3SR35_NATMM Unreviewed; 649 AA.
AC D3SR35;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Putative DNA helicase Rad25 {ECO:0000256|HAMAP-Rule:MF_01489};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01489};
GN Name=rad25b {ECO:0000313|EMBL:ADD06591.1};
GN Synonyms=rad25 {ECO:0000256|HAMAP-Rule:MF_01489};
GN OrderedLocusNames=Nmag_3039 {ECO:0000313|EMBL:ADD06591.1};
GN ORFNames=C500_05203 {ECO:0000313|EMBL:ELY31948.1};
OS Natrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 /
OS IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3) (Natronobacterium
OS magadii).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natrialba.
OX NCBI_TaxID=547559 {ECO:0000313|EMBL:ADD06591.1, ECO:0000313|Proteomes:UP000001879};
RN [1] {ECO:0000313|Proteomes:UP000001879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM
RC 8861 / NBRC 102185 / NCIMB 2190 / MS3
RC {ECO:0000313|Proteomes:UP000001879};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Davenport K., Saunders E., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Kyrpides N., Mikhailova N., De Castro R.E.,
RA Maupin-Furlow J.A., Woyke T.;
RT "Complete sequence of chromosome of Natrialba magadii ATCC 43099.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADD06591.1, ECO:0000313|Proteomes:UP000001879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43099 {ECO:0000313|EMBL:ADD06591.1}, and ATCC 43099 / DSM
RC 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 /
RC NCIMB 2190 / MS3 {ECO:0000313|Proteomes:UP000001879};
RX PubMed=22559199; DOI=10.1186/1471-2164-13-165;
RA Siddaramappa S., Challacombe J.F., Decastro R.E., Pfeiffer F., Sastre D.E.,
RA Gimenez M.I., Paggi R.A., Detter J.C., Davenport K.W., Goodwin L.A.,
RA Kyrpides N., Tapia R., Pitluck S., Lucas S., Woyke T., Maupin-Furlow J.A.;
RT "A comparative genomics perspective on the genetic content of the
RT alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T.";
RL BMC Genomics 13:165-165(2012).
RN [3] {ECO:0000313|EMBL:ELY31948.1, ECO:0000313|Proteomes:UP000011543}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM
RC 8861 / NBRC 102185 / NCIMB 2190 / MS3
RC {ECO:0000313|Proteomes:UP000011543}, and MS-3
RC {ECO:0000313|EMBL:ELY31948.1};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
RN [4] {ECO:0000313|EMBL:ADD06591.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 43099 {ECO:0000313|EMBL:ADD06591.1};
RA Pfeiffer F.;
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01489};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637, ECO:0000256|HAMAP-Rule:MF_01489}.
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DR EMBL; CP001932; ADD06591.1; -; Genomic_DNA.
DR EMBL; AOHS01000023; ELY31948.1; -; Genomic_DNA.
DR RefSeq; WP_004214707.1; NZ_AOHS01000023.1.
DR AlphaFoldDB; D3SR35; -.
DR STRING; 547559.Nmag_3039; -.
DR PaxDb; 547559-Nmag_3039; -.
DR GeneID; 8825899; -.
DR KEGG; nmg:Nmag_3039; -.
DR PATRIC; fig|547559.17.peg.997; -.
DR eggNOG; arCOG00874; Archaea.
DR HOGENOM; CLU_008213_4_0_2; -.
DR OrthoDB; 8379at2157; -.
DR Proteomes; UP000001879; Chromosome.
DR Proteomes; UP000011543; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01489; Helicase_Rad25_arch; 1.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR030882; Helicase_Rad25_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01489};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01489, ECO:0000313|EMBL:ADD06591.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01489, ECO:0000313|EMBL:ADD06591.1};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01489};
KW Reference proteome {ECO:0000313|Proteomes:UP000001879}.
FT DOMAIN 296..445
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 497..646
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 72752 MW; 311BF17ED8CC8451 CRC64;
MTDERSSATR SGEHPPDDSD DTPSDTPSDD EDTGESTSAS GTTSHSLSLE SFHDACQQAG
RPVLTAGAVA RALDRPHEAI SEDLDALTER GALERLSVST DPVVWYPSEL EDLTDRERVV
VFPKRREIIV DRPDQFTRAQ LAQFAHLADG NGEEGYRYVV RPEDIWQAPH DSFDELARTM
RQALGQRSRA LEDWVESQWD RAHQFRLTTH EEGYTVLEAK SPEVMGNVAR QKLDEEHVHA
PISETEDWVR EGAEAAIKRI LYEAGYPVQD HRELEAGEQL DIELGVSLRD YQQTWVDRFA
EAGEGVFVGP PGSGKTVAAM GAMAHVGGET LVLVPSRDLA RQWAEAIEEY TSLEPDQIGQ
YHGGQKNVRP VTIATYQIAG MDRHRSLFDD REWGLVVFDE CQHVPSDVYR RSTHLQSRHR
LGLSASPIRE DDRQTEIFTL VGPPIGTDWQ ALFEAGFVAE PELEIRYVPW GDDEQSNAYA
SADGRERYRI AARNRGKIDE VRYLLSAHPG SKSLVFVDYL EQGRDLSDAL DVPFLSGETP
HHERRRLLEE FRRDERDLLI VSRVGDEGID LPTADLAIVA SGLGGSRRQG TQRAGRTMRP
AGGALVYVLA TRGTREEDFA RRQLQHLGRK GMTVREETIE REDDASDGQ
//
