UniProt: D3SRH6

Database: UniProt
Entry: D3SRH6_NATMM

LinkDB:  D3SRH6_NATMM 
Original site:  D3SRH6_NATMM

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (5)   
   InterPro (4)   
   Pfam (1)   
Literature (2)   
   PubMed (2)   
All databases (18)   

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ID   D3SRH6_NATMM            Unreviewed;       118 AA.
AC   D3SRH6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=DNA-directed RNA polymerase subunit Rpo4 {ECO:0000256|HAMAP-Rule:MF_00864};
DE            EC=2.7.7.6 {ECO:0000256|HAMAP-Rule:MF_00864};
DE   AltName: Full=DNA-directed RNA polymerase subunit F {ECO:0000256|HAMAP-Rule:MF_00864};
GN   Name=rpoF {ECO:0000256|HAMAP-Rule:MF_00864,
GN   ECO:0000313|EMBL:ADD04681.1};
GN   Synonyms=rpo4 {ECO:0000256|HAMAP-Rule:MF_00864};
GN   OrderedLocusNames=Nmag_1097 {ECO:0000313|EMBL:ADD04681.1};
GN   ORFNames=C500_18006 {ECO:0000313|EMBL:ELY25337.1};
OS   Natrialba magadii (strain ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 /
OS   IAM 13178 / JCM 8861 / NBRC 102185 / NCIMB 2190 / MS3) (Natronobacterium
OS   magadii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natrialba.
OX   NCBI_TaxID=547559 {ECO:0000313|EMBL:ADD04681.1, ECO:0000313|Proteomes:UP000001879};
RN   [1] {ECO:0000313|Proteomes:UP000001879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM
RC   8861 / NBRC 102185 / NCIMB 2190 / MS3
RC   {ECO:0000313|Proteomes:UP000001879};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Davenport K., Saunders E., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Kyrpides N., Mikhailova N., De Castro R.E.,
RA   Maupin-Furlow J.A., Woyke T.;
RT   "Complete sequence of chromosome of Natrialba magadii ATCC 43099.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ADD04681.1, ECO:0000313|Proteomes:UP000001879}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43099 {ECO:0000313|EMBL:ADD04681.1}, and ATCC 43099 / DSM
RC   3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM 8861 / NBRC 102185 /
RC   NCIMB 2190 / MS3 {ECO:0000313|Proteomes:UP000001879};
RX   PubMed=22559199; DOI=10.1186/1471-2164-13-165;
RA   Siddaramappa S., Challacombe J.F., Decastro R.E., Pfeiffer F., Sastre D.E.,
RA   Gimenez M.I., Paggi R.A., Detter J.C., Davenport K.W., Goodwin L.A.,
RA   Kyrpides N., Tapia R., Pitluck S., Lucas S., Woyke T., Maupin-Furlow J.A.;
RT   "A comparative genomics perspective on the genetic content of the
RT   alkaliphilic haloarchaeon Natrialba magadii ATCC 43099T.";
RL   BMC Genomics 13:165-165(2012).
RN   [3] {ECO:0000313|EMBL:ELY25337.1, ECO:0000313|Proteomes:UP000011543}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43099 / DSM 3394 / CCM 3739 / CIP 104546 / IAM 13178 / JCM
RC   8861 / NBRC 102185 / NCIMB 2190 / MS3
RC   {ECO:0000313|Proteomes:UP000011543}, and MS-3
RC   {ECO:0000313|EMBL:ELY25337.1};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
RN   [4] {ECO:0000313|EMBL:ADD04681.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 43099 {ECO:0000313|EMBL:ADD04681.1};
RA   Pfeiffer F.;
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-dependent RNA polymerase (RNAP) catalyzes the
CC       transcription of DNA into RNA using the four ribonucleoside
CC       triphosphates as substrates. This subunit is less well bound than the
CC       others. {ECO:0000256|HAMAP-Rule:MF_00864}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.6; Evidence={ECO:0000256|HAMAP-Rule:MF_00864};
CC   -!- SUBUNIT: Part of the RNA polymerase complex. Forms a stalk with Rpo7
CC       that extends from the main structure. {ECO:0000256|HAMAP-
CC       Rule:MF_00864}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00864}.
CC   -!- SIMILARITY: Belongs to the eukaryotic RPB4 RNA polymerase subunit
CC       family. {ECO:0000256|HAMAP-Rule:MF_00864}.
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DR   EMBL; CP001932; ADD04681.1; -; Genomic_DNA.
DR   EMBL; AOHS01000056; ELY25337.1; -; Genomic_DNA.
DR   RefSeq; WP_004216955.1; NZ_AOHS01000056.1.
DR   AlphaFoldDB; D3SRH6; -.
DR   STRING; 547559.Nmag_1097; -.
DR   PaxDb; 547559-Nmag_1097; -.
DR   GeneID; 8823928; -.
DR   KEGG; nmg:Nmag_1097; -.
DR   PATRIC; fig|547559.17.peg.3543; -.
DR   eggNOG; arCOG01016; Archaea.
DR   HOGENOM; CLU_165892_0_0_2; -.
DR   OrthoDB; 25158at2157; -.
DR   Proteomes; UP000001879; Chromosome.
DR   Proteomes; UP000011543; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR   Gene3D; 6.10.140.10; -; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   HAMAP; MF_00864; RNApol_arch_Rpo4; 1.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR005574; Rpb4/RPC9.
DR   InterPro; IPR010924; Rpo4.
DR   PANTHER; PTHR39646:SF1; DNA-DIRECTED RNA POLYMERASE SUBUNIT RPO4; 1.
DR   PANTHER; PTHR39646; RNA POLYMERASE RPB4; 1.
DR   Pfam; PF03874; RNA_pol_Rpb4; 1.
DR   PIRSF; PIRSF005053; RNA_pol_F_arch; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00864};
KW   DNA-directed RNA polymerase {ECO:0000256|HAMAP-Rule:MF_00864,
KW   ECO:0000313|EMBL:ADD04681.1};
KW   Nucleotidyltransferase {ECO:0000256|HAMAP-Rule:MF_00864,
KW   ECO:0000313|EMBL:ADD04681.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001879};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00864};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00864, ECO:0000313|EMBL:ADD04681.1}.
SQ   SEQUENCE   118 AA;  13530 MW;  14AD5E00F0780EDA CRC64;
     MTIFKEIVDE EFLTVSETKG LLADIEADRA LDEERELPYE LARAIDHVNQ FTVLEPDDAQ
     DLVTDLQEIE KVDEPTAYKI ANLLPRNRSE LRSVYAQQRY SLSGEELDDI LNVVAKYA
//

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