ID D3TAJ5_ACIB4 Unreviewed; 784 AA.
AC D3TAJ5;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Aboo_1316 {ECO:0000313|EMBL:ADD09124.1};
OS Aciduliprofundum boonei (strain DSM 19572 / T469).
OC Archaea; Candidatus Thermoplasmatota; DHVE2 group; Aciduliprofundum.
OX NCBI_TaxID=439481 {ECO:0000313|EMBL:ADD09124.1, ECO:0000313|Proteomes:UP000001400};
RN [1] {ECO:0000313|Proteomes:UP000001400}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 19572 / T469 {ECO:0000313|Proteomes:UP000001400};
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA Kyrpides N., Mikhailova N., Flores G., Reysenbach A.-L., Woyke T.;
RT "Complete sequence of Aciduliprofundum boonei T469.";
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; CP001941; ADD09124.1; -; Genomic_DNA.
DR AlphaFoldDB; D3TAJ5; -.
DR KEGG; abi:Aboo_1316; -.
DR HOGENOM; CLU_000203_6_0_2; -.
DR Proteomes; UP000001400; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR CDD; cd00145; POLBc; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000313|EMBL:ADD09124.1};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:ADD09124.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001400};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ADD09124.1}.
FT DOMAIN 81..242
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 351..750
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 784 AA; 91295 MW; 64ED63CC6E0DFF69 CRC64;
MRCLYVYWDV RLLTASYSRE EDGVVVELYG KTREGKSIVV RYKGFKPYFY LVEPPSTILE
KFSQDPEIYK MEEVELWHKG KVRKCVKVTL HSPWKTPRYR REALEFCDVL AADIPFHQRF
IYDFDLGSCV RVYGKEEEKG KYTTELVVNA EKFENIGDFK PPLKILSFDI ENSMKNGRIF
TIGIAIWENG EIRKESIEGD EKDILWKFLE MIWKEDPDII TGYNIDGYDL ELLSERYKKY
GMDFLIGRDK SKPQRIVGQF WRLHGRVIED AWWAVKKELR LKQETLQAVA MHLFGEGKLD
VDRTNIDEEW EKDKEKVIEY CKKDAELALR ILLQIGIINK YLDLATVTKF PLEDVIHSGT
STWVDSLLIR EADRHNIGVP LQGQERKSRK IEGGYVHTIE PGLYHWVCVL DFKSMYPSII
IKYNICFTTL SKDGDIVSPT GVRFLSKEKR EGLIPKLLAE LMKKRDELKR KMKEDPDNRD
YYNGLQKAVK ILMNTFYGVL ASSFYRFTNP DIGASITAFA RDTIKRIIAE LESEGIKVVY
GDTDSVFFQS PYEDLENTIE FGMRKAEEIS RREKLILEFE KILEPFFSHG AKKRYVGRII
WPDEEKGNMV VRGYEIRRTD SFDLQSEAQR AVFEKILDGD IQGAIELARE IVSKVRAGKV
PIESLVISRT VKDFKFYKNP DSMPNVQAAR KLIKMGQEFI PGMKVAWIVV NARGSKQDVE
PYIPGMEFNR KPDYRYYARR VAETLARITD VFGVDEENLL TGSRQISLGA FGKEKKKKTL
FDFE
//
