ID   D3TC07_ACIB4            Unreviewed;       338 AA.
AC   D3TC07;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:ADD08092.1};
DE            EC=3.5.4.4 {ECO:0000313|EMBL:ADD08092.1};
GN   OrderedLocusNames=Aboo_0281 {ECO:0000313|EMBL:ADD08092.1};
OS   Aciduliprofundum boonei (strain DSM 19572 / T469).
OC   Archaea; Candidatus Thermoplasmatota; DHVE2 group; Aciduliprofundum.
OX   NCBI_TaxID=439481 {ECO:0000313|EMBL:ADD08092.1, ECO:0000313|Proteomes:UP000001400};
RN   [1] {ECO:0000313|Proteomes:UP000001400}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19572 / T469 {ECO:0000313|Proteomes:UP000001400};
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Flores G., Reysenbach A.-L., Woyke T.;
RT   "Complete sequence of Aciduliprofundum boonei T469.";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR   EMBL; CP001941; ADD08092.1; -; Genomic_DNA.
DR   RefSeq; WP_012997091.1; NC_013926.1.
DR   AlphaFoldDB; D3TC07; -.
DR   GeneID; 8827223; -.
DR   KEGG; abi:Aboo_0281; -.
DR   HOGENOM; CLU_039228_7_0_2; -.
DR   Proteomes; UP000001400; Chromosome.
DR   GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:InterPro.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   CDD; cd01320; ADA; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   HAMAP; MF_01962; Adenine_deaminase; 1.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR028892; ADE.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:ADD08092.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001400}.
FT   DOMAIN          10..329
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   338 AA;  38520 MW;  4D61D6B40D60671B CRC64;
     MVSSLINALP KAELHIHVEG TLEPVLMMSL ARNNNVSIPY NSIDEIKNAY RFKNLEDFLR
     LYYSGLRVLK DEDDFYILTM NYLKRASENN VRHVELSFDP QAHTRRGVRF EEVIEGIHSA
     LKDGERKYGI SWVIILSILR DLSVEDALHT LSRAEEYKDI IDAIGLDSAE VGNPPSKFKK
     VFEKAKTSGF HLVAHAGEEG PPSYIKEAID LGVERIDHGV RAIEDETLMK MLGRMRIAFT
     LCPLSNLKLN VVKSLKNYPI REFSKVGIRV TINSDDPAYF GGYINKNYEE VAKALNLKPK
     EIIEIARNSI IASFASDERK REILREINDV EKNYFESA
//