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Database: UniProt
Entry: D3TM18_GLOMM
LinkDB: D3TM18_GLOMM
Original site: D3TM18_GLOMM 
ID   D3TM18_GLOMM            Unreviewed;       137 AA.
AC   D3TM18;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   03-JUL-2019, entry version 31.
DE   RecName: Full=Mediator of RNA polymerase II transcription subunit 9 {ECO:0000256|RuleBase:RU364145};
DE   AltName: Full=Mediator complex subunit 9 {ECO:0000256|RuleBase:RU364145};
GN   Name=MED9 {ECO:0000256|RuleBase:RU364145};
OS   Glossina morsitans morsitans (Savannah tsetse fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Hippoboscoidea; Glossinidae; Glossina.
OX   NCBI_TaxID=37546 {ECO:0000313|EMBL:ADD18746.1};
RN   [1] {ECO:0000313|EMBL:ADD18746.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Salivary gland {ECO:0000313|EMBL:ADD18746.1};
RX   PubMed=20353571; DOI=10.1186/1471-2164-11-213;
RA   Alves-Silva J., Ribeiro J.M., Van Den Abbeele J., Attardo G., Hao Z.,
RA   Haines L.R., Soares M.B., Berriman M., Aksoy S., Lehane M.J.;
RT   "An insight into the sialome of Glossina morsitans morsitans.";
RL   BMC Genomics 11:213-213(2010).
RN   [2] {ECO:0000313|EMBL:ADD18746.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Salivary gland {ECO:0000313|EMBL:ADD18746.1};
RG   International Glossina Genome Initiative;
RA   da Silva J., Ribeiro J.M.C., Abbeele J.V., Attardo G., Hao Z.,
RA   Haines L.R., Soares M.B., Berriman M., Aksoy S., Lehane M.J.;
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Proteomes:UP000092444, ECO:0000313|VectorBase:GMOY010769-PA}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444,
RC   ECO:0000313|VectorBase:GMOY010769-PA};
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of
RT   African Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000092444}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Yale {ECO:0000313|Proteomes:UP000092444};
RG   International Glossina Genome Initiative W.H.O.;
RA   Lawson D.;
RT   "Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of
RT   African Trypanosomiasis.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|VectorBase:GMOY010769-PA}
RP   IDENTIFICATION.
RC   STRAIN=Yale {ECO:0000313|VectorBase:GMOY010769-PA};
RG   VectorBase;
RL   Submitted (JUL-2016) to UniProtKB.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator
CC       involved in the regulated transcription of nearly all RNA
CC       polymerase II-dependent genes. Mediator functions as a bridge to
CC       convey information from gene-specific regulatory proteins to the
CC       basal RNA polymerase II transcription machinery. Mediator is
CC       recruited to promoters by direct interactions with regulatory
CC       proteins and serves as a scaffold for the assembly of a functional
CC       preinitiation complex with RNA polymerase II and the general
CC       transcription factors. {ECO:0000256|RuleBase:RU364145}.
CC   -!- SUBUNIT: Component of the Mediator complex.
CC       {ECO:0000256|RuleBase:RU364145, ECO:0000256|SAAS:SAAS00869477}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364145,
CC       ECO:0000256|SAAS:SAAS00869478}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 9 family.
CC       {ECO:0000256|RuleBase:RU364145}.
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DR   EMBL; CCAG010005888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; EZ422470; ADD18746.1; -; mRNA.
DR   VectorBase; GMOY010769-RA; GMOY010769-PA; GMOY010769.
DR   Proteomes; UP000092444; Unassembled WGS sequence.
DR   GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR   GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR037212; Med7/Med21-like.
DR   InterPro; IPR011425; Med9.
DR   InterPro; IPR039242; MED9_metazoa.
DR   PANTHER; PTHR20844; PTHR20844; 1.
DR   Pfam; PF07544; Med9; 1.
DR   SUPFAM; SSF140718; SSF140718; 1.
PE   2: Evidence at transcript level;
KW   Activator {ECO:0000256|RuleBase:RU364145};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000092444};
KW   Nucleus {ECO:0000256|RuleBase:RU364145,
KW   ECO:0000256|SAAS:SAAS00869474};
KW   Reference proteome {ECO:0000313|Proteomes:UP000092444};
KW   Transcription {ECO:0000256|RuleBase:RU364145,
KW   ECO:0000256|SAAS:SAAS00869482};
KW   Transcription regulation {ECO:0000256|RuleBase:RU364145,
KW   ECO:0000256|SAAS:SAAS00869473}.
FT   COILED       77     97       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   137 AA;  15480 MW;  77FB115005F3D385 CRC64;
     MELSPNADAV DIKPTLTADG LIKTSPTAPS TTTANTTAGN SGLTVARLDI EILPVIYDIL
     RCVEKDPLDN STKQRESQEC SQKILELQKR FESARNQIKQ LPGIDYNKEE QLQKLELLHN
     QLTLKQQLIR KYKDIQF
//
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