ID D3V0K0_XENBS Unreviewed; 2864 AA.
AC D3V0K0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Synthetase CbsF {ECO:0000313|EMBL:CBJ80574.1};
DE EC=5.1.1.11 {ECO:0000313|EMBL:CBJ80574.1};
GN OrderedLocusNames=XBJ1_1441 {ECO:0000313|EMBL:CBJ80574.1};
OS Xenorhabdus bovienii (strain SS-2004).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=406818 {ECO:0000313|EMBL:CBJ80574.1, ECO:0000313|Proteomes:UP000002045};
RN [1] {ECO:0000313|EMBL:CBJ80574.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SS-2004 {ECO:0000313|EMBL:CBJ80574.1};
RX PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L.,
RA Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.,
RA Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P.,
RA Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R.,
RA Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S.,
RA Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R.,
RA Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C.,
RA van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B.,
RA Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S.,
RA Goodrich-Blair H.;
RT "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus:
RT convergent lifestyles from divergent genomes.";
RL PLoS ONE 6:E27909-E27909(2011).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- PATHWAY: Siderophore biosynthesis. {ECO:0000256|ARBA:ARBA00004924}.
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DR EMBL; FN667741; CBJ80574.1; -; Genomic_DNA.
DR RefSeq; WP_012987966.1; NC_013892.1.
DR STRING; 406818.XBJ1_1441; -.
DR KEGG; xbo:XBJ1_1441; -.
DR PATRIC; fig|406818.4.peg.1304; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_000022_0_1_6; -.
DR Proteomes; UP000002045; Chromosome.
DR GO; GO:0047462; F:phenylalanine racemase (ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:CBJ80574.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 999..1073
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2534..2609
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2864 AA; 320231 MW; 8AB44C1233008C7F CRC64;
MSSRLQEVGV ETINLTLPLV AAQPGIWIAD QLADPRNIFT IAHYIEIKGA LDQPLFDAAI
CQGLSEADTI HARYFLNEDG IPVQQIPLCC DPQQVIAPEW IDFSREPAGQ AEIASQTLMQ
EDLSAELPAD GERALYRQVV MKIDKQPERW FWYQRFHHLM LDGFSFDALT RRIIQIYNAL
KAEHPPAETP FCSFTQVVEE YQDWQSSPAK AKAAAFWQEY TREPGACVSL SVEDIAASEN
TSPLYYHCHF PATQLTSLMA EDSLRQFQPA EIAMAALGIY FYRMCGEKHL SIGFPFMRRL
GSAALCSTGP VVNLLPLQIK LQDSMTLADV VKAFVAEIKQ VRRHQRYDAE QLRCHLGLSG
SSNLLYGPVF NYKIYNETLK LDGKPITTHT LATGPVDDLE FELNFQDDVL HLTFIANRTK
YSEQTLHWHS ERIRYLLDQL LIQPKQPIAF IPMIPPQEQQ RLDEWSRGPC VTPPSDRVSV
LDFFLSQVKQ QPDTLAVRCG DQQLSYHQLM AKSMQLARLL LAQGIGAEDV VAIGVPRSID
SVVAILGVLA SGAAYMPLDL DYPRERLQLM SDDAQPVLLI TCINTLPQMP DIPKVICLDD
HQIQERCTSL SSLPVTDEER RETLRGEHLA YIIYTSGSTG KPKGVMSTHG GLLNLLASHA
ARLFGPVIDN FHLQHQRRMR AGHTASFSFD SSWEPLFCMM LGSELYIFDE ELRRDAWGVV
QQMNQLPVDL MDITPSFLTQ LIDSGLLEEG NHQPAFIMIG GEAATPRLWE LLKQYPQMNI
HNYYGPSEYT IDTLGADIQV ADQPVIGRPV ANTDVWLLDS HLQPVPVGAV GELYLSGPGI
ARGYLRRPDL TAARFVANPF KNGEVMYRSG DLMRWRPDGQ LSFVGRVDHQ IKVRGFRVEL
GEVENALAAL PEVSSAVVIA EPMGVTYRLI GYCSVPDNKL RALADISARL LAELAKQLPD
YMVPALLVIL EELPLTVNGK VDRKALPKPQ QQHFSIGRQA ENEKEKYICE AFATLLGIVQ
VSADDDFFVL GGDSISAMAL GTQLRRVGWQ LRPRDIFSER TPARMALKMS PVAIGKRTSS
ANKISKPVQI GEIDHLPILH WFAESHGINT RFAHGVFIRV PAELRPEHLS SALLALSQTH
PVLHAVTRNN RLIIGEKPVL ADGSYYSVIQ NSGHIETSAE QAFHEAVMRL NPATGHLFHA
CLLQQDEETQ GLVWVIHHLA TDGVSWRVLL DELQQAIETA IAGKAITLPP EEYTLYDWNL
QLGQNLVNRA GELSFWQAML DEKIPLLGKR PLDAHRDRQV AVREQRTLLT GKQTTALLGV
LPQQYHANIE EMLLTILAMA CNRHFGVSKF RFQLESHGRM ELEDDVDLAR TVGWLTAEYP
VVLALPQAEH QSTKIADENP SKIVRAVKSA LRTIPDRGIG YGLLRYLDQT GRQVLAQQDT
PEILFNYLGR FAATDNLWAP QRTENLFRDT FAVYQDPQMS PNHSLEINLF VDEQGSIPQL
AINWQWVDGI FSEQDISELQ RGMEWATDCL INFARQQPRQ AAATLVAAEI VLPRLEESDL
TQLTERYGPL ATVLPLLPLQ QGLLFHAQTA TDKGNYNSLT RLSLHGSLDR VKLHRALSAL
IRHHPQLAAR FDTEQSASPL QLIPLLSEDS DIWPLDFYQL PELPEQEEEA ALLELERTEL
ARDLFHQPQA MLHALLVCHG EGSRYTLLLN IHHLVVDGWS TPILIQDLLT LLNQGEQALS
VPRVSYQEIV HQLAAQETAV ARQCWQDVLK GVQPTKLFSD QPHNGKVKEL DIALEPEMEQ
ALFSLCQQRG LTLNTLMQGI WSVLLSIHSG SSDVVFGSPV SGRFGQIEGL DQHVGLFSNT
LPVRMTLDIT LPLLPQLEQL QAQQIQLIEH DNIGLGEIQH IAGTSTLFDT LLVVENYPET
DTESDCTQTI ICQRINNRGY THYPLTLLVL PGKRLRLLME YRECVKQPEL LAQRILLLIQ
QLLEQPDTAL QDWVLQSPDE AALITKVNRT HHEIPSGTLH QFVIEQAEKT PDDLALLDNQ
HHLTYRQMRA QTRLLVDRLI EAGVQPGDIV GVALPRSVRL SLALQAILEA GAAWLPLDTG
YPDDRLAMML EDAQPRLVIT ESKLQARFAH QAPLLVFDQL ADENQQPVHP AAWVTPQHTA
YIIYTSGSTG RPKGVMVSHQ SIVNRLLWMQ DAYPLTQDDV VLQKTPCSFD VSVWEFFWPL
MTGAKLVMAP PEVHRDPEAL MQLIDDYAVT TLHFVPSMLA TLIDSLASRQ QSALFCHSLR
QVFCSGEALS CELARRYQTF ISAPLHNLYG PTEAAVDVTW QPAYGEALDH CTGSGVPIGR
PVWNTQLRIL DAWLRPVPVG VAGDLYLCGI QLATGYLNRA DLTASRFVAD PFACGERMYR
TGDIACWLPN GEVEYLGRSD DQLKIRGQRI ELGEIEQVLL EQSGIAQAAV AACELGKTAN
TVSDADARQL VAWLIPQPDV SLDTEALHQA LTRRLPAYML PVSYVLQDSF PLSANGKLNR
KALPMPQKLT TGRLPVAGME SQMAALFAEI LDCDTVWADD DFFALGGHSL LAMRLAAEIR
RRFNRSISIG HIMVARSVEK LSALLSDENE QDSAENRGLG EVFPLRDGHG SALFCLHPAS
GFAWQYSGLL RYLKGDWPII GLQSPRPLGV IADSDNLEDM CTHHLATLRQ IQPHGPYYLL
GYSLGGMLAQ GMAARLRQEG EKVAFLGLLD TYPPEGQDWT VLSEEEAKEE AAREQAEFMA
ATEDERDPLL RAEKQAMFAD IVANYKDSVR ILSSASNQKY DGEAILFSAT RTLPADMDVA
ATWAPWIRQL SIYRQDCEHA DILSPASLKQ LGPLLNTLLK THRD
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