ID D3VEI8_XENNA Unreviewed; 5480 AA.
AC D3VEI8;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Phenylalanine racemase (ATP-hydrolyzing) {ECO:0000313|EMBL:CBJ90100.1};
DE EC=5.1.1.11 {ECO:0000313|EMBL:CBJ90100.1};
DE EC=5.1.1.12 {ECO:0000313|EMBL:CBJ90100.1};
GN OrderedLocusNames=XNC1_2040 {ECO:0000313|EMBL:CBJ90100.1};
OS Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / CCUG 14189 / LMG
OS 1036 / NCIMB 9965 / AN6).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ90100.1, ECO:0000313|Proteomes:UP000008075};
RN [1] {ECO:0000313|EMBL:CBJ90100.1, ECO:0000313|Proteomes:UP000008075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19061 / DSM 3370 / CCUG 14189 / LMG 1036 / NCIMB 9965 /
RC AN6 {ECO:0000313|Proteomes:UP000008075};
RX PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L.,
RA Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.,
RA Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P.,
RA Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R.,
RA Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S.,
RA Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R.,
RA Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C.,
RA van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B.,
RA Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S.,
RA Goodrich-Blair H.;
RT "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus:
RT convergent lifestyles from divergent genomes.";
RL PLoS ONE 6:E27909-E27909(2011).
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN667742; CBJ90100.1; -; Genomic_DNA.
DR STRING; 406817.XNC1_2040; -.
DR KEGG; xne:XNC1_2040; -.
DR eggNOG; COG1020; Bacteria.
DR HOGENOM; CLU_222916_0_0_6; -.
DR Proteomes; UP000008075; Chromosome.
DR GO; GO:0050157; F:ornithine racemase activity; IEA:UniProtKB-EC.
DR GO; GO:0047462; F:phenylalanine racemase (ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd17652; A_NRPS_CmdD_like; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd12117; A_NRPS_Srf_like; 3.
DR CDD; cd19544; E-C_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 3.40.50.980; -; 8.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 5.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Isomerase {ECO:0000313|EMBL:CBJ90100.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008075}.
FT DOMAIN 1010..1085
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2076..2150
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3189..3264
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4264..4338
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5367..5442
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5480 AA; 608980 MW; AEDA68F0CFFEA7C9 CRC64;
MSMSCNRINN EDKSSVNKDS STCQFSLSTT QQVVWLDHIL RPDSPCYNIG SVVLIEGKLD
EALLRRSFET VVYRHDALRL RLIETQGLPL QELKKTLPVE MTIHDFSDYA DAEGQAKKHL
RNAFMRTFDL NGELWHFDLI RVNNQRWYWQ FLCHHLIGDS ITFKLIPESI ADAYNRLLKG
EEFTEIPPSY LDFIHEDHDY LNSQRYRQDR QFWQERYKNV SPTLISPSIS TKAGQPESTE
PLFWELDKAL FQCIEETVAA QGLSVLHFMY AVLACYFFRT LHFSRTNDAE EIVIGIPVYN
RKNIRQKRTV GMFSSVIPVG VTLAPHDTFL DIMNKAAAEL RRCYKRQRLP ITEINQNIQV
QQKTGHAQLF DIMLSYEWVE VNASIPNATL TYTQIQRGTP FPLLIAIYQY AFADSEDIHK
PVTLEFNFSP DYLTRAEIVA LKSRLRVLIE AAIASPDTQI RHLPIVPHAE QQQLLVNFNA
TQADFPQQTL IHQQVEAQVA RCPEAPAVTF GELTFSYGEL NRRANQLAHH LIALGVRPDD
RVAICLERHP DLIIGLLAIL KAGGAYLPLD PAYPTERLAY IFQDAEPVVL LTQTAHAGKL
GSAISERKAE KSIPTLLLDT QALFPAEQPS HNPDAQALDL TSRHLAYVIY TSGSTGQPKG
VMVEHRNVLR LIINNGFAEL GRDDCVAHCA NIAFDASTWE IWSALLNGGR LHLVSQSELL
DPVRFHDSLM QGQVTALWLT AGLFNEYLDT LKPLFGQLRY LLVGGDVLDP RKIRQVQQAE
SQPAHLLNGY GPTETTTFAT ICVIASPVDI AHAIPIGRPI GNTQIYILDP QRQPVPLGVA
GEIYIAGAGV ARGYLNRPDL TAERFLIDPF SQDANARIYK TGDLGRWLPD GNIDYLGRND
FQVKIRGFRI EPGEIEAKLM EYRGVREAVV LARPDESGQQ HLVAYLQSHT DTELIPAELR
QHLARHLADY MLPSAFVILD SFPLTPNGKL DRQALPAPDL SAVVTRHYAA PEGEIEITLA
QIWQKLLRLE QVGRHDHFFE LGGHSLLAIQ LIAHIRQDMA RELSLQQLFD RPVLLDLAKM
LTGISATNQI SIPVTDRDQR LPLSFAQQRL WFLSQLDQAA SLAYHIPVAL RLTGQLNRHA
LSDALDSLVA RQEILRTRFV LVAGHPYQHI DPADTGFTLS YQDLRPWAPE THTHRIEALT
VLEAQTPFDF TQGPLIRGHL LQLSDKEHVL LITQHHIISD GWSIGVLIHE LSALYRAVLD
NQESSLAPLP VQYADYAVWQ RNQLQDTAVT EQRDFWHSQL KGAPALLTLP TDRPRPATQS
FVGGFIPVRI DADLLASLKA LGQRHNTTLF MTVLSAWSLV LARLSGQDDI VIGTPVANRP
HQALEGLIGF FVNTLALRVR FNHVHRVTDL LAHIRQQALT AYAHQELPFE QVVEALQPER
DLSYSPIFQV MLALNNIPAE ALTLPDLQFT PVEQAHRSAH FDITLSLTET ESGLTGDLTY
AADLFDAATA ERMVGYLTNV LTAMVTDETQ SVATLPMLPE SEQQQLLVDF NATQADFPHD
SLSHQLFEAQ AAHRPEATAV VFEGQQLSYG ELNRRANRLA HYLIAQGVRP DDRVAVCSER
NPRMVISLLA ILKAGGAYVP LDPAYPAERL AYMLDDAAPV TLLTQTDWVD KLSSALPISS
VLTTILLDND ELLLAAQPTD NPNPQRLGLT PHHLAYVIYT SGSTSQPKGV MIEHQSLCNL
MTTQQNTLAL TADSRVLQFA SNSFDACIWE CCMAFQSGGS LYLAKRADIL PGAVLSGYLR
DNLISHVLLS PTALAAMDSL PDTLHTLLVG GEACTSTLVK RWSQGRRMLN AYGPTEITVC
ATIYSCAHYS DDRAEDNPPP IGRPIANTQI YILDAHAQPV PRGVIGEIYI AGAGVARGYL
NRPELTAERF LTDPFSTNSD ARMYKTGDLG HWLPDGNIEY LGRNDFQIKL RGFRIEPGEI
ETRLRQCHGV REAVVLAREN SETTQKRLVA YLLPQSGAEL EPAKLRQQLA QHLAEHMLPS
AFVTLEAFPL TPNGKLDRQA LPEPESSAIV TRHHESPMGE AETSLAQIWQ KLLGVKQVSR
HDHFFELGGY SLMIVSLIEE LRNLGWQLDV RSVFAAPILA DMAQVIRREA NAFVVPANLI
PENCAAITPD MLPLVSLSQA EIDAIVVTVS GGASNVQDIY PLAPLQEGIL FHHLLQTQGD
DYVLQVLLAF NTRAQLDAFL NALQQVIDRH DILRTSAYWQ DLAQPVQVVW RQAALSINVF
MPDSENDVLS QLQAHTDPRL HRINLNQAPL FTADIAHDPV QGEWLLALRF HHLVSDHMTL
DLIFAEMALI LQGNILRENV QTLPYRNFIA QILNVSPAIH EAYFREQLAG IDEPTAPFGV
FTLPKETQKQ SEPANARRSV AKNRILLPSG LSDDIRIQAR RLGVSPSVLF HVAWAQVLAQ
TSGHNDVVFG SVLSGRLQGG AGADRILGMF INTLPFRISL NGCNVQDIVQ ETYRNLTTLL
EHEQAPLALA QRCSEVAQPM PIFSTLLNYR HSQTAKGHTG EAVNAMWAEM RLLSAEERTN
YPITLSVDDL GHDFQLTALT ITEIVPEHIT TYMATAIKGL VNALAHAPKK SILDVPILPE
AERQKLLVDF NATQTDFPQD RLIHSLVEAQ AALRPDATAV IGKGHRLSYS ELNQRANRLA
HHLIALGVQP DDRVAICLER SPEMVIGLLA ILKAGGAYVP LDPTYPAERL TYMLDDVAPI
ALLTQTAWVN KLASILPATL PTVLLDNALH HQDAFLPAES NENPDIQALG LTSRHLAYVI
YTSGSTGQPK GVMVEHRNVL RLVINNRFAD IGPDDCIAHC ANVSFDATTW EVWGGLIQGA
RILLIPEKTL LQPADFGQHL SDEGVSALFL TTALFNQYAN LIAPALSGLR YVLFGGEKTD
TRAAIRLRAE HSPDHLLHVY GPTETATFAT AYEIPLMEDN DTEITIPIGQ PIANTQAYIL
DGTGRPVPVG VAGEIYIAGA GVARGYLNRP ELTAERFLAD PFSSGPEARM YKTGDLGRWL
PDGNIEYLSR NDTQVKLRGF RIELGEIETC LRQCHGVREA VVLLRADAAH ESTSTEEQKR
LVAYLRPQTG IKLVPAELRQ QLAQHLADYM LPSAFVMLES FPLTPNGKLD RQALPAPDAS
SVVSRGYEAP VGETEIALAQ IWQDLLGLER VGRHDHFFEL GGHSLLAVQL ASRIRQVLAK
ELSLQQLFDQ PLLADLAQAL TGASVTAQAT IPVADRNQPL PLSFAQQRLW FLGQLDPAAS
LAYHIPAALR LSGLLNPPAL SGALDRLVAR QEILRTRFVL VDGQPCQHID PADRGFTLSY
QDLRPLTPEK QSHRIAEMTA REAQTPFDFT QGPLIRGHLL QLADEEHVLL LTQHHIISDG
WSIGVLMNEL STLYSHVLNG QASPLPPLPI QYADYAVWQR HWLQDATLTT QRDFWCEKLS
GAPTLLTLPT DRPRPTVHSY AGNRVPVCFS ADLLTSLKGL GQRHNTTLFM SVLSAWSIVL
ARLSGQDDIV IGTPIANRPH HELEGMIGFF VNTLALRIRF SDELSVVDLL AQVKEQAFAA
YAHQDLPFEQ VVEALQPERS LSYSPVFQVM LSLNHMPTQT LTLPDLQLIP MEQDHHSAHF
DLTLSLTETE EGLVGELAYA VDLFDTATIE RMIGYLTNVL TAMVTNETQA VATLPMLPES
ERQQLLTGFN TVRMNFPQDR LIHQLFEAQA AAQPDAVAVV LEEQTLSYGE LNRCANRLAH
HLIAQGVRPD TRVAICVERS LEMVVGLLAI LKAGGAYVPL DPAYPADRLA YMFEDAAPVA
LLTQTEWLDK FANVLSAVTL PTTLLDPLPD NQESFLATQP SNNPDTQALG LTSRHLAYII
YTSGSTGQPK GVMVEHANII RLFAATQARF QFDNHDVWTL FHSFAFDFSV WELWGALVYG
GRLVVIPADC ARSPHRFYSL LCREQVTVLN QTPSAFRQLI SAQDATPHSL RYIIFGGEAL
ELHTLAPWVA RNPTQQTRLV NMYGITEITV HATYRELTEA DIHAGRGSLI GQPLADLRIY
ILDTCGQPVP PGVTGELYIV GDGVARGYLN RPELTAERFL ADPFSPDSQA RMYKTGDLGR
WLADGNLEYL GRNDFQVKIR GFRIELGEIE ARLEQCHGVR EAVVLARADD NGQKRLIAYL
LPQDNAELVP AELRQQLSQH LADYMLPSAF VTLESFPLTT NGKLDRQALP APDSSAVVVH
RYEAPAGEME IVLARIWQHL LKLERVGRHD HFFELGGHSL MIVSLIEELR RLGWQLDVRS
VFIAPVLAEM AQTIHRDTHA FVVPDNLIPE NCTAITPDML PLVCLSQAEI DAIVATVPGG
ANNVQDIYPL APLQEGILFH HLLQAQGDNY LLQSLLAFDS RERLDTFLTT LQHVIDRHDI
LRTAAYWQDL EQPVQVVWRQ AVLTVNVFNP VTADNVADQL RAQTDPRTHR LALDRAPLFA
ANIAYDPAQT EWLLVLRFHH LVSDHMTLEL IFAEMALLLK KNEPKKNKLK NNKLQGNTEK
LPVALPYRNF VAQTLNMPTA DHEAYFRAQL ADIHEPTAPF GILNVQTESE RVTEDRLFVT
PDLAESIRAQ ARRLGVSPSV LFHAAWALVL AQTCDRDDVV FGSVLLGRLQ GGAGADQVLG
MFINTLPMRV SLAQRTVKDV VQATYHNLMM LLEHEQAPLV LAQQCSGMPQ SMPLFSTLLN
YRHSQPGNVA ATDTFWSGMR ILAAEERTNY PITLSVDDLG DDFRLTAQAI AGIEPARVIR
YLVTAISGLV NALVREPQRL MRDIAILPAT ERQQLLVDFN ATESHFPQNG LIHPLFEAQA
ARNPDTIAIE FAGQTLSYGE VNRRANRLAH HLIALGVRPD SRVAICVERS PALIIGLLAI
LKAGGAYVPL DPNYPAERLT YILDDSAPVA LLTQEAHLNK LSATLPTVLL DNDETLLATQ
PIDNPDIQAL GLTSHHLAYV LYTSGSTGQP KGVMTEHRNV LRLIINSGFA DIGPDDCIAH
CANMAFDAST WEIWSALLNG ARLHVVSPSV LLDPVRFCDS LMQGQVTALW LTAGLFHEYL
DTLKPLYGQL RYLLVGGDIL DPGKIQQVKL AESQPAHLIN GYGPTETTTF ATTYDIASPV
DVTRSIPIGR PIGNTRIYIL DSRGQPVPLG IVGEIHIAGA GVARGYLNRP ELTTERFLLD
PFSQGTHARM YKTGDLGRWL PEGNIEYLGR YDFQIKLRGF RIEPGEIETK LRQCHGVDEA
VVLAREETAY ENPTGQKRLV AYLRPLDGVE LMPAELRQQL ARQLADYMLP SAFVILDSFP
LTPNGKLDRQ ALPAPDASAA ATREYEPPKG RIETVLAQIW QELLDLSRIS RHDNFFEIGG
HSLMVVRLIT RIQNKLLVNI PLTSLFAAPT LKEQADIILS AQMEAIGDNE IESMQDDLDS
MSAEELMALL GDENTHGDGR
//
