ID D3VFL0_XENNA Unreviewed; 2530 AA.
AC D3VFL0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Peptidase C80 domain-containing protein {ECO:0000259|PROSITE:PS51771};
GN OrderedLocusNames=XNC1_2265 {ECO:0000313|EMBL:CBJ90324.1};
OS Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / CCUG 14189 / LMG
OS 1036 / NCIMB 9965 / AN6).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Xenorhabdus.
OX NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ90324.1, ECO:0000313|Proteomes:UP000008075};
RN [1] {ECO:0000313|EMBL:CBJ90324.1, ECO:0000313|Proteomes:UP000008075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19061 / DSM 3370 / CCUG 14189 / LMG 1036 / NCIMB 9965 /
RC AN6 {ECO:0000313|Proteomes:UP000008075};
RX PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C., de Leon L.,
RA Drace K., Du Z., Givaudan A., Herbert Tran E.E., Jewell K.A., Knack J.J.,
RA Krasomil-Osterfeld K.C., Kukor R., Lanois A., Latreille P.,
RA Leimgruber N.K., Lipke C.M., Liu R., Lu X., Martens E.C., Marri P.R.,
RA Medigue C., Menard M.L., Miller N.M., Morales-Soto N., Norton S.,
RA Ogier J.C., Orchard S.S., Park D., Park Y., Qurollo B.A., Sugar D.R.,
RA Richards G.R., Rouy Z., Slominski B., Slominski K., Snyder H., Tjaden B.C.,
RA van der Hoeven R., Welch R.D., Wheeler C., Xiang B., Barbazuk B.,
RA Gaudriault S., Goodner B., Slater S.C., Forst S., Goldman B.S.,
RA Goodrich-Blair H.;
RT "The entomopathogenic bacterial endosymbionts xenorhabdus and photorhabdus:
RT convergent lifestyles from divergent genomes.";
RL PLoS ONE 6:E27909-E27909(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host cytosol
CC {ECO:0000256|ARBA:ARBA00023586}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; FN667742; CBJ90324.1; -; Genomic_DNA.
DR RefSeq; WP_013184339.1; NC_014228.1.
DR STRING; 406817.XNC1_2265; -.
DR KEGG; xne:XNC1_2265; -.
DR eggNOG; COG2931; Bacteria.
DR eggNOG; COG5263; Bacteria.
DR HOGENOM; CLU_000475_0_0_6; -.
DR Proteomes; UP000008075; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0044164; C:host cell cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd20501; C80_RtxA-like; 1.
DR Gene3D; 3.40.50.11050; -; 1.
DR InterPro; IPR020974; CPD_dom.
DR InterPro; IPR038383; CPD_dom_sf.
DR InterPro; IPR049824; RtxA-like_C80.
DR InterPro; IPR024769; TcdA/TcdB_pore_forming.
DR Pfam; PF11713; Peptidase_C80; 1.
DR Pfam; PF12920; TcdA_TcdB_pore; 1.
DR PROSITE; PS51771; CGT_MARTX_CPD; 1.
PE 4: Predicted;
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host membrane {ECO:0000256|ARBA:ARBA00022511};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 928..1108
FT /note="Peptidase C80"
FT /evidence="ECO:0000259|PROSITE:PS51771"
SQ SEQUENCE 2530 AA; 284612 MW; 4C53CA996B82C5BC CRC64;
MVYMSDDFKN LLNTLIDQQV EAAGRQTEWF RMDTKERDIY ISQVGEQLQE MQQSTLNVLA
AQHFQMQDNP VSIDDHLQTL QQGRQQVDSR PNTPARKAYE QQLDRDIQLY RRQQAAITHF
NKARKEALDI LNPGGSQIFN VMTLREDSVD KQDKLDTKIK DLDQLLTTQV PDSTFSPKYV
KWFSRLQAYK DVKARYIDLL RTPSEEETKE AEALRKLTEV PLASDELPVN ISLLMMEERP
GYIRMNVALV NASTDGRFKD FFLKDGRLVV PKDGVFNFSF GTPARSLAWQ QQYRLKSEPP
SFRSPTYTPI RSVLVKIGFV EKYFAHYLVS ESTEREGFKA HFLDSDRKIL LINVDRKVPN
QIGIKVSGQL AGLSDLINQN ADITSFQTIG LEDFRLNGYD PDRDGPFINI HELERSVGFS
NRQYLLEMPK DNSYLSATPF GVTNFDGDKV SSSHLSKAQT EVLYQYNLEF FNKLEQLLDG
DDTQFSRLFK DSSESNERTA FEQQLVRLLE RNHITPAGVL VPKYTRDGMR DIKGNNLNKV
VWEQAFATSV WENLNDDPLL SKLANKLNSL VFSSTTTVDK ILKNSYVQSD IFQVKALLAL
QYEQWRIQAI EEETQRINRI NAELHPSNPK THDFNQTEVE RSLDRKLLAL LLVGPENFER
TNEPLYPDVK AALLSNEGRS LRKQVLFHAL RPVADSFSKA ALPVNPHATL GEDKVIINNR
LHQPDPFLIL NTRPEEQAYH DGSHLITDDK YRSYSQFRPD PKNQATLYMN DLDTPFVGGI
SGTTQTVSNV LPKLFGDTLS VKEYWNFQMA NAAFMIRNGY HSFFETFYVA ARYEPEGAGS
IGKDMLQMFD KYRDEGREKA LQSELYDGVM ERVLPIINQG LPEAEKFHSP RFTRFDPMPA
LLDKKEPAGI APFDEKPVSN WEQPIVEAHH EGGTSRFDGQ LIIQLENDPV VREAAAKLVG
KHPNSVLVQL DAQGQYQVVH GNLTLLKDKE KIRWQLVGHS RDGGDKLNHQ TLAKRTPEVL
ASQLSQFGTD SGIETSPEHI SMVSCSLADE GQQESYALKF AQSLDPRIRP LSVKAYAAQI
MVSPEGRKQL TENGNKVTLV FNPEQGVWEK TVTPGKSVPA GGMVNPPLGD PMALVPDDAQ
IDIRLLAMLN RAEDFQQATE QLYSKNALST EEWLPVLGSL RETESQPGSY SLQFINTARS
KVPPRTFTTD DQRIINFIHS YDNDLKVVSK SHKYTEGKFT LRTGILEAEA VHGLNSAFII
KTLIPWFADR NRTTVASDKA SNTTTNTLET ALRVHTYVNL TQMAHGALED SAKLVSLYRA
MASESRGVTS SLFSSLSHVS TGVGVGLNIT SVVLDSLELA HAQNESQKAV YGTQLAFDSA
GLVTTGVGIG AGVFGAPIVA GVASSLAVPL AGLGIGFTAL AEAFGRVADD AKAVGNYFAD
LDAAYQQGGY RRTEKVAANG NPYTVMEPIP GAVIRQLDLR HGNLTFDSQY LYRNDPTYSV
GSGHSNYFFW WPGRSANTKK TQAINIREGI GHKQAQIDLP FHPRSSDILI LPVTMKSYIN
YEYMSLPFVT ARNDRGFDVL RRLEEDGRFD FDFYAFPSER VVRRIKPEFV ETPVDIILDD
QDRDIVIQQL PEDVHGILSY RLTGGKGKYR ISLQKGVSLS LQGNNTATHW ILDASHIDSD
FDASLSKKDN RQLHIGSIKI TLPETSVNIS LINNAGVFSV GQNKEHQWQI TEIETNADQF
NSLQALHDHL RQLSNSDHHN RPYVVVEHYR HSPPQSRPVG RAFYETGRDR MIYTNVPDAA
DFLNNVELAK VKGDKAWFYR DTTLWQVNIA SGEVLRQYLP TMFPESDQGK ISSHVMQSND
QLWFVVEQQR DENRISYTYQ VEEEALKLVA VDGNTAILAA LDKVSKEISL PVPLGSSDGE
LNGLLAPQAA TQRFTVNLCA PERQVKDSPA EVISLSGQVA GVDRHYWLQT DGKQLQDVVR
MNRINPDQED ADILAERIKK NSDLPTLTLT ADFTRVFTTA GDKPGYYFYS HQRHRLYFQQ
DNGLSDTPTS KVAVDDIRSV SIVNNQLVAL SSRGMLWLAD DQGSIRLIGV TADWLLQPHQ
QGLTAALRQL AQDTPDQFST LLLLGLQDKD GKPVSAWYDS KADLVVQGRV GLNTEHTLVY
LGLAEAEDGK QAWIFDTDNH QLYRQPLSTE TDLKLIGKRE LSGEPAAAEP WPRASQQYRS
AVRQGNTLRL ETPDGAVLLL SADAKMTDRP MLIAWHVQDH PDSQIVSAIV ALSNEAELSQ
AVRLFSEHGY PAWYLPKEKK TLRSGILNPD HVLHYLGRVA GQEASYVHDQ TTGDLWQVSE
GESIPVRVGN YRFVNRTPEI LVLQVGQVPP EGKIQLPQLS GTDRLAITGR SEKLYYWLSP
SEALIHYRYI TIDDRGQDSV IRFSDTGIAN LLLWRSNQDL VLLHQAAEDT SIRIVNIEQA
VQRDMRFEMT LKRMKIIHLL RRMAKLMILN PDVSCFALIS GESELRIKPA ERTEKSGSFS
PILTNSVLID
//
