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Database: UniProt
Entry: D3YT08_CAEEL
LinkDB: D3YT08_CAEEL
Original site: D3YT08_CAEEL 
ID   D3YT08_CAEEL            Unreviewed;       461 AA.
AC   D3YT08;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2013, sequence version 2.
DT   11-DEC-2019, entry version 76.
DE   SubName: Full=Inward Rectifying K (Potassium) channel family {ECO:0000313|EMBL:CCD62725.2};
GN   Name=irk-2 {ECO:0000313|EMBL:CCD62725.2,
GN   ECO:0000313|WormBase:M02A10.2b};
GN   ORFNames=CELE_M02A10.2 {ECO:0000313|EMBL:CCD62725.2}, M02A10.2
GN   {ECO:0000313|WormBase:M02A10.2b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD62725.2, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD62725.2, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD62725.2,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; BX284606; CCD62725.2; -; Genomic_DNA.
DR   RefSeq; NP_001256976.2; NM_001270047.2.
DR   SMR; D3YT08; -.
DR   PaxDb; D3YT08; -.
DR   EnsemblMetazoa; M02A10.2b.1; M02A10.2b.1; WBGene00002150.
DR   GeneID; 191695; -.
DR   CTD; 191695; -.
DR   WormBase; M02A10.2b; CE49104; WBGene00002150; irk-2.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00980000198471; -.
DR   InParanoid; D3YT08; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00002150; Expressed in 4 organ(s), highest expression level in multi-cellular organism.
DR   ExpressionAtlas; D3YT08; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM        70..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          33..173
FT                   /note="IRK"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          180..351
FT                   /note="IRK_C"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
SQ   SEQUENCE   461 AA;  53020 MW;  FB61545C69800410 CRC64;
     MLDIEEPLVK NKKYPFFKTP RLGGSRRIRN RLVQKQGLCN ISLKNVPKQR RKYFSDIFTT
     VIEMKWRWCL LYFSLSFMIS WSFFATVYFL IAKQHGDIEQ IANATWTPCI VNVHNELNAF
     LFSFTTQTTI GYGFRYPTDA CPLTIVTMCF QFMWGVMTQT LMAGIIFSKL ARPIKRAATL
     IFSKNAVICL RDGKLCLLFR VGDMRKSSLA EAHVRLQMIK RCVTYEGELL PFHQFDMDVG
     YDQGLDRVFV IWPITICHEI DERSPLWEIG ADDLKSAKFE IIAILEGVVE SVGSTTQART
     SYLPSEILWG HRFEKLVHYK KENGQYNIDF GKFHNVYSVN TPTCSAAEIE RLRSEGIFNE
     SEYQMYPPSD NKLNLLDNDE MSPVRDSIDL NQIQILRRDS DEDPDAGEES MELVDLGIHH
     KCSIRSQSPI INSTSHLLQP MHKNSCSVRR GSSTLNVSLH G
//
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