ID D3YT54_CAEEL Unreviewed; 611 AA.
AC D3YT54;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Rho-GAP domain-containing protein {ECO:0000313|EMBL:CBK19426.1};
GN Name=srgp-1 {ECO:0000313|EMBL:CBK19426.1,
GN ECO:0000313|WormBase:F12F6.5c};
GN ORFNames=CELE_F12F6.5 {ECO:0000313|EMBL:CBK19426.1}, F12F6.5
GN {ECO:0000313|WormBase:F12F6.5c};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CBK19426.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CBK19426.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CBK19426.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CBK19426.1; -; Genomic_DNA.
DR RefSeq; NP_001255568.1; NM_001268639.1.
DR AlphaFoldDB; D3YT54; -.
DR SMR; D3YT54; -.
DR PeptideAtlas; D3YT54; -.
DR EnsemblMetazoa; F12F6.5c.1; F12F6.5c.1; WBGene00006406.
DR GeneID; 178079; -.
DR AGR; WB:WBGene00006406; -.
DR WormBase; F12F6.5c; CE44561; WBGene00006406; srgp-1.
DR HOGENOM; CLU_289546_0_0_1; -.
DR OrthoDB; 2875730at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00006406; Expressed in adult organism and 4 other cell types or tissues.
DR ExpressionAtlas; D3YT54; baseline and differential.
DR GO; GO:0005912; C:adherens junction; IDA:WormBase.
DR GO; GO:0005938; C:cell cortex; IDA:WormBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IDA:WormBase.
DR GO; GO:0043621; F:protein self-association; IPI:WormBase.
DR GO; GO:0031267; F:small GTPase binding; IPI:WormBase.
DR GO; GO:0030336; P:negative regulation of cell migration; IGI:WormBase.
DR GO; GO:0060101; P:negative regulation of phagocytosis, engulfment; IGI:WormBase.
DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; IGI:WormBase.
DR GO; GO:0070587; P:regulation of cell-cell adhesion involved in gastrulation; IGI:WormBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14166:SF17; RHO-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:D3YT54,
KW ECO:0007829|PeptideAtlas:D3YT54};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 79..267
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 22..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 67877 MW; 067DCA74C60A8E78 CRC64;
MERLEARSAS IGEALGKHGI SLKSASVGSA SERNGSFTTE NGGSQNHHLL EERRSKARRI
GGIVTKSPDD RPRPKLFGGS LDEYVEATGE EIPLLVQSAI AYLSRYSLRN QGLFRVSGSQ
SEINRFREAY ERGEDLFQYL DDGSDANSAA GVLKLYFREL REPIFPIFMF EQFCDCAKSE
SPTEFVRRAR ELVSKLPVSH VLLLRFLFAF LSHLCEFADE NMMEPHNLAI CFGPTLLPIP
EGKDQVFYHN YVNELVRNLI IHADDVFPRD LAGPVYDKYA MQRYMDGNFI EENDLISEDD
EAHEKLSLPP SRHMMIDSTY ESADRILLSS PILSQANTST PNGISPSNGA ESSTHNEIDY
APIASSRSSN RSKASGSIDL AMRSEMPHRI ANELNNIFKN SSLSSEGSKG ISVLRHSHVE
PSWTDNREHL NMRSMSTDPD EEREYVSPPP PLLSTKYVSA ASCSISPAPR TIDIKERKDS
RDLLYAPITR ATTVPANSGS NTEMNSTGVR PIGKSSLRDQ LQLMRKENST EMKPSTSLNG
STKKLDSETT ILDARSTDKS TESSRRTSLE DDKSPEPFAQ PDIINSARPR GKSPTLDDIL
NSLKVATSIS P
//
