ID D3YUE5_MOUSE Unreviewed; 127 AA.
AC D3YUE5;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human) {ECO:0000313|Ensembl:ENSMUSP00000120798.2};
DE Flags: Fragment;
GN Name=Nipa2 {ECO:0000313|Ensembl:ENSMUSP00000120798.2,
GN ECO:0000313|MGI:MGI:1913918};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000120798.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000120798.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120798.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000120798.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120798.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NIPA family.
CC {ECO:0000256|ARBA:ARBA00007230}.
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DR AlphaFoldDB; D3YUE5; -.
DR ProteomicsDB; 323080; -.
DR Antibodypedia; 22214; 58 antibodies from 17 providers.
DR Ensembl; ENSMUST00000152649.8; ENSMUSP00000120798.2; ENSMUSG00000030452.17.
DR AGR; MGI:1913918; -.
DR MGI; MGI:1913918; Nipa2.
DR VEuPathDB; HostDB:ENSMUSG00000030452; -.
DR GeneTree; ENSGT00940000155651; -.
DR ChiTaRS; Nipa2; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000030452; Expressed in epithelium of small intestine and 244 other cell types or tissues.
DR ExpressionAtlas; D3YUE5; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF1; MAGNESIUM TRANSPORTER NIPA2; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:D3YUE5,
KW ECO:0007829|ProteomicsDB:D3YUE5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 127
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000120798.2"
SQ SEQUENCE 127 AA; 13546 MW; 6AB54A2A1D9FFEF5 CRC64;
MSLGRGKYDF YIGLGLAMTS SIFIGGSFIL KKKGLLRLAR KGSMRAVGAG EVANFAAYAF
APATLVTPLG ALSVLVSAIL SSYFLNERLN LHGKIGCLLS ILGSTVMVIH APKEEEIETL
NEMSHKL
//
