ID D3YUE7_MOUSE Unreviewed; 627 AA.
AC D3YUE7;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=GRAM domain containing 4 {ECO:0000313|Ensembl:ENSMUSP00000120796.2};
GN Name=Gramd4 {ECO:0000313|Ensembl:ENSMUSP00000120796.2,
GN ECO:0000313|MGI:MGI:2676308};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000120796.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000120796.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120796.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000120796.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120796.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001192282.1; NM_001205353.1.
DR AlphaFoldDB; D3YUE7; -.
DR SMR; D3YUE7; -.
DR MaxQB; D3YUE7; -.
DR PeptideAtlas; D3YUE7; -.
DR ProteomicsDB; 365797; -.
DR Antibodypedia; 28118; 67 antibodies from 14 providers.
DR Ensembl; ENSMUST00000138134.8; ENSMUSP00000120796.2; ENSMUSG00000035900.19.
DR GeneID; 223752; -.
DR UCSC; uc007xdw.3; mouse.
DR AGR; MGI:2676308; -.
DR CTD; 23151; -.
DR MGI; MGI:2676308; Gramd4.
DR VEuPathDB; HostDB:ENSMUSG00000035900; -.
DR GeneTree; ENSGT00390000010968; -.
DR OrthoDB; 3028864at2759; -.
DR BioGRID-ORCS; 223752; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Gramd4; mouse.
DR Proteomes; UP000000589; Chromosome 15.
DR Bgee; ENSMUSG00000035900; Expressed in interventricular septum and 246 other cell types or tissues.
DR ExpressionAtlas; D3YUE7; baseline and differential.
DR Genevisible; D3YUE7; MM.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR CDD; cd13221; PH-GRAM_GRAMDC4; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR037847; GRAMDC4.
DR InterPro; IPR037845; GRAMDC4_PH-GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR37402; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR37402:SF1; GRAM DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02893; GRAM; 1.
DR SMART; SM00568; GRAM; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:D3YUE7,
KW ECO:0007829|MaxQB:D3YUE7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 276..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 475..553
FT /note="GRAM"
FT /evidence="ECO:0000259|SMART:SM00568"
FT REGION 47..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 72134 MW; 9E4055C7F8CAF5DF CRC64;
MRVGPDHPAG EPPRHVQVRP RSAVLNMLRR LDRIRFRGHK REDLLDLAES PNASDTECGD
EIPLKTPRPS PRDSEELRDP AGPGTLIMAA GVQDFNRTEF DRLNEIKGHL EIALLEKHFL
QEELRKLREE TNSEMLRQEL DRERQRRIEL EQKMQEVLKA RSEEQPAQPQ QPPKGQSQAS
NGTGTERRSQ GLASRVQKWF YERFGEYIED FRFQPEENTV ETEEPLSARR LTENMRRLKR
GAKPVTNFVK NLSALSDWYS IYTSAIAFTV YMNAVWHGWA IPMFLFLAIL RLSLNYLIAR
GWRIQWSIVP EVSEAVEPAK EDLTVSEKFQ LVLDVAQKAQ NLFGKMADIL EKIKNLFMWV
QPETTQKLYV ALWAAFLASC FFPYRLVGLA VGLYAGIKFF LIDFIFKRCP RLRAKYDTPY
IIWRSLPTDP QLKERAGATV SRRLQTASSR SYVSSAPAGL SKDEDAGRFH STKKGNFHEI
FNLTENERPL AVCENGWRCC LINRDRKMPT DYIRNGVLYV TENYLCFESS KSGSSKRNKV
IKLMDITDIQ KEESVLDEWG LASPLSLGEA GGPVAMVVLF HFSIKSCLSS LAQAWELLFL
HHQPRNPWCS VPWCTEMKPL RPFSASM
//
