ID D3YUF4_MOUSE Unreviewed; 1046 AA.
AC D3YUF4;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Mcf.2 transforming sequence-like {ECO:0000313|Ensembl:ENSMUSP00000106495.2};
GN Name=Mcf2l {ECO:0000313|Ensembl:ENSMUSP00000106495.2,
GN ECO:0000313|MGI:MGI:103263};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000106495.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:15345747}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000106495.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106495.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000106495.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106495.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; D3YUF4; -.
DR SMR; D3YUF4; -.
DR MaxQB; D3YUF4; -.
DR ProteomicsDB; 355083; -.
DR Antibodypedia; 1984; 167 antibodies from 32 providers.
DR Ensembl; ENSMUST00000110871.8; ENSMUSP00000106495.2; ENSMUSG00000031442.22.
DR AGR; MGI:103263; -.
DR MGI; MGI:103263; Mcf2l.
DR VEuPathDB; HostDB:ENSMUSG00000031442; -.
DR GeneTree; ENSGT00940000157874; -.
DR ChiTaRS; Mcf2l; mouse.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000031442; Expressed in olfactory epithelium and 221 other cell types or tissues.
DR ExpressionAtlas; D3YUF4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Proteomics identification {ECO:0007829|EPD:D3YUF4,
KW ECO:0007829|MaxQB:D3YUF4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1046
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003052920"
FT DOMAIN 20..192
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 600..780
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 798..914
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 523..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 924..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..595
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 118562 MW; 876EE3BFB9DDCFD6 CRC64;
MTLSLISVLS QDVTALWLLL KTSADEIMHQ DIVPLCAADI QEQLKKRFAY LSGGRGQDGS
PVITFPDYPA FSEIPDKEFQ NVMTYLTSIP SLQDAGIGFI LVIDRRQDKW TSVKASVLRI
AASFPANLQL VLVLRPTGFF QRTLSDIAFK FNRDEFKMKV PVMMLSSVPE LHGYIDKSQL
TEDLGGTLDY CHSRWLCHRT AIESFALMVK QTAQMLQAFG TELAETELPN DVQSTSLVLS
AHTEKKAKVK EDLQLALKEG NSILESLREP LAESAAHSVN QDQLDNQATV QRLLAQLNET
EAAFDEFWAK HQQKLEQCLQ LRHFEQGFRE VKTTLDSMSQ KIAAFTDVGN SLAHVQHLLK
DLTAFEEKSS VAVDKARALS LEGQQLIENR HYAVDSIHPK CEELQHLCDH FASEVTRRRG
LLSKSLELHS LLETSMKWSD EGIFLLASQP VDKCQSQDGA EAALQEIEKF LETGAENKIQ
ELNEIYKEYE CILNQDLLEH VQKVFQKQES TEEMFHRRQA SLKKLAAKQT RPVQPVAPRP
EALTKSPSPS PGSWRSSENS SSEGNALRRG PYRRAKSEMS EPRQGRTSST GEEEESLAIL
RRHVMNELLD TERAYVEELL CVLEGYAAEM DNPLMAHLIS TGLQNKKNIL FGNMEEIYHF
HNRIFLRELE SCIDCPELVG RCFLERMEEF QIYEKYCQNK PRSESLWRQC SDCPFFQECQ
KKLDHKLSLD SYLLKPVQRI TKYQLLLKEM LKYSKHCEGA EDLQEALSSI LGILKAVNDS
MHLIAITGYD GNLGDLGKLL MQGSFSVWTD HKKGHTKVKE LARFKPMQRH LFLHEKAVLF
CKKREENGEG YEKAPSYSYK QSLNMTAVGI TENVKGDTKK FEIWYNAREE VYIIQAPTPE
IKAAWVNEIR KVLTSQLQAC REASQHRALE QSHSLPLPTP SSTSPTKGNT RNVKKLEDRK
TDPLSLEGYV SSSLPKPPEK GKAHWSHRRR PPHLWSPGTS TRCTLGCSTA LPTFLSMGPW
PLAPAILPPG CYLCTLSLLP PRRCGP
//
