ID D3YWU3_MOUSE Unreviewed; 148 AA.
AC D3YWU3;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=AP-3 complex subunit mu-1 {ECO:0000256|ARBA:ARBA00041150};
DE AltName: Full=AP-3 adaptor complex mu3A subunit {ECO:0000256|ARBA:ARBA00041639};
DE AltName: Full=Adaptor-related protein complex 3 subunit mu-1 {ECO:0000256|ARBA:ARBA00043091};
DE AltName: Full=Mu-adaptin 3A {ECO:0000256|ARBA:ARBA00041291};
DE AltName: Full=Mu3A-adaptin {ECO:0000256|ARBA:ARBA00042377};
DE Flags: Fragment;
GN Name=Ap3m1 {ECO:0000313|Ensembl:ENSMUSP00000115157.2,
GN ECO:0000313|MGI:MGI:1929212};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000115157.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000115157.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115157.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000115157.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000115157.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC not clathrin-associated. The complex is associated with the Golgi
CC region as well as more peripheral structures. It facilitates the
CC budding of vesicles from the Golgi membrane and may be directly
CC involved in trafficking to lysosomes. In concert with the BLOC-1
CC complex, AP-3 is required to target cargos into vesicles assembled at
CC cell bodies for delivery into neurites and nerve terminals.
CC {ECO:0000256|ARBA:ARBA00025605}.
CC -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer composed
CC of two large adaptins (delta-type subunit AP3D1 and beta-type subunit
CC AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and
CC a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with
CC AGAP1. AP-3 associates with the BLOC-1 complex.
CC {ECO:0000256|ARBA:ARBA00038709}.
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC {ECO:0000256|ARBA:ARBA00005324}.
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DR AlphaFoldDB; D3YWU3; -.
DR SMR; D3YWU3; -.
DR MaxQB; D3YWU3; -.
DR PeptideAtlas; D3YWU3; -.
DR ProteomicsDB; 364048; -.
DR Antibodypedia; 45437; 145 antibodies from 28 providers.
DR Ensembl; ENSMUST00000130370.3; ENSMUSP00000115157.2; ENSMUSG00000021824.14.
DR AGR; MGI:1929212; -.
DR MGI; MGI:1929212; Ap3m1.
DR VEuPathDB; HostDB:ENSMUSG00000021824; -.
DR GeneTree; ENSGT00940000158184; -.
DR HOGENOM; CLU_1668822_0_0_1; -.
DR OMA; INVHFTI; -.
DR ChiTaRS; Ap3m1; mouse.
DR Proteomes; UP000000589; Chromosome 14.
DR Bgee; ENSMUSG00000021824; Expressed in ectoplacental cone and 260 other cell types or tissues.
DR ExpressionAtlas; D3YWU3; baseline and differential.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14837; AP3_Mu_N; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR001392; Clathrin_mu.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR10529; AP COMPLEX SUBUNIT MU; 1.
DR PANTHER; PTHR10529:SF342; AP-3 COMPLEX SUBUNIT MU-1; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PRINTS; PR00314; CLATHRINADPT.
DR SUPFAM; SSF64356; SNARE-like; 1.
PE 1: Evidence at protein level;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Proteomics identification {ECO:0007829|EPD:D3YWU3,
KW ECO:0007829|MaxQB:D3YWU3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 1..128
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
FT NON_TER 148
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000115157.2"
SQ SEQUENCE 148 AA; 16910 MW; A573FF38802E606F CRC64;
MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS TPHHYLISIY
RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA AIKDNVVIVY ELLEEMLDNG
FPLATESNIL KELIKPPTIL RSVVNSIT
//
