ID D3YXP1_MOUSE Unreviewed; 57 AA.
AC D3YXP1;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Cyclin-dependent kinases regulatory subunit {ECO:0000256|RuleBase:RU311113};
GN Name=Cks1b {ECO:0000313|Ensembl:ENSMUSP00000103045.2,
GN ECO:0000313|MGI:MGI:1889208};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000103045.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000103045.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103045.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000103045.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000103045.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC kinases and is essential for their biological function.
CC {ECO:0000256|ARBA:ARBA00002449, ECO:0000256|RuleBase:RU311113}.
CC -!- SUBUNIT: Forms a homohexamer that can probably bind six kinase
CC subunits. {ECO:0000256|ARBA:ARBA00011253}.
CC -!- SIMILARITY: Belongs to the CKS family. {ECO:0000256|ARBA:ARBA00007782,
CC ECO:0000256|RuleBase:RU311113}.
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DR AlphaFoldDB; D3YXP1; -.
DR SMR; D3YXP1; -.
DR MaxQB; D3YXP1; -.
DR PeptideAtlas; D3YXP1; -.
DR ProteomicsDB; 303948; -.
DR Antibodypedia; 47036; 283 antibodies from 26 providers.
DR Ensembl; ENSMUST00000107422.2; ENSMUSP00000103045.2; ENSMUSG00000028044.7.
DR AGR; MGI:1889208; -.
DR MGI; MGI:1889208; Cks1b.
DR VEuPathDB; HostDB:ENSMUSG00000028044; -.
DR GeneTree; ENSGT00950000182971; -.
DR HOGENOM; CLU_140546_2_1_1; -.
DR ChiTaRS; Cks1b; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR Bgee; ENSMUSG00000028044; Expressed in endocardial cushion and 247 other cell types or tissues.
DR ExpressionAtlas; D3YXP1; baseline and differential.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.170.10; Cyclin-dependent kinase, regulatory subunit; 1.
DR InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR PANTHER; PTHR23415:SF50; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 1; 1.
DR PANTHER; PTHR23415; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7; 1.
DR Pfam; PF01111; CKS; 1.
DR PRINTS; PR00296; CYCLINKINASE.
DR SMART; SM01084; CKS; 1.
DR SUPFAM; SSF55637; Cell cycle regulatory proteins; 1.
DR PROSITE; PS00945; CKS_2; 1.
PE 1: Evidence at protein level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU311113};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU311113};
KW Proteomics identification {ECO:0007829|EPD:D3YXP1,
KW ECO:0007829|PeptideAtlas:D3YXP1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
SQ SEQUENCE 57 AA; 6795 MW; AF146FBD21BD7563 CRC64;
MLPKDIAKLV PKTHLMSESE WRNLGVQQSQ GWVHYMIHEP EPHILLFRRP LPKKPKK
//
