ID D3YXY0_MOUSE Unreviewed; 183 AA.
AC D3YXY0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Protein kinase C, iota {ECO:0000313|Ensembl:ENSMUSP00000123671.2};
DE Flags: Fragment;
GN Name=Prkci {ECO:0000313|Ensembl:ENSMUSP00000123671.2,
GN ECO:0000313|MGI:MGI:99260};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000123671.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000123671.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123671.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000123671.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000123671.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; D3YXY0; -.
DR SMR; D3YXY0; -.
DR MaxQB; D3YXY0; -.
DR PeptideAtlas; D3YXY0; -.
DR ProteomicsDB; 345338; -.
DR Antibodypedia; 4271; 271 antibodies from 37 providers.
DR Ensembl; ENSMUST00000130238.2; ENSMUSP00000123671.2; ENSMUSG00000037643.15.
DR AGR; MGI:99260; -.
DR MGI; MGI:99260; Prkci.
DR VEuPathDB; HostDB:ENSMUSG00000037643; -.
DR GeneTree; ENSGT00940000153497; -.
DR HOGENOM; CLU_1294013_0_0_1; -.
DR OMA; FIDWEAL; -.
DR ChiTaRS; Prkci; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR Bgee; ENSMUSG00000037643; Expressed in molar tooth and 277 other cell types or tissues.
DR ExpressionAtlas; D3YXY0; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20794; C1_aPKC; 1.
DR CDD; cd06404; PB1_aPKC; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR034877; PB1_aPKC.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00564; PB1; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00666; PB1; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:D3YXY0,
KW ECO:0007829|MaxQB:D3YXY0};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..72
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT DOMAIN 104..154
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 164..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 183
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000123671.2"
SQ SEQUENCE 183 AA; 21333 MW; DB4A9EA2547EE02F CRC64;
MITHFEPSIS FEGLCSEVRD MCSFDNEQPF TMKWIDEEGD PCTVSSQLEL EEAFRLYELN
KDSELLIHVF PCVPERPGMP CPGEDKSIYR RGARRWRKLY CANGHTFQAK RFNRRAHCAI
CTDRIWGLGR QGYKCINCKL LVHKKCHKLV TIECGRHSLP PEPMMPMDQT MHPDHTQTVI
PYN
//
