ID D3YY49_MOUSE Unreviewed; 398 AA.
AC D3YY49;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
GN Name=Lipo2 {ECO:0000313|Ensembl:ENSMUSP00000118907.2,
GN ECO:0000313|MGI:MGI:3644466};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000118907.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000118907.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118907.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000118907.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000118907.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR RefSeq; NP_001309267.1; NM_001322338.1.
DR RefSeq; XP_003945643.1; XM_003945594.4.
DR AlphaFoldDB; D3YY49; -.
DR SMR; D3YY49; -.
DR STRING; 10090.ENSMUSP00000118907; -.
DR ESTHER; mouse-Lipo2; Acidic_Lipase.
DR MaxQB; D3YY49; -.
DR PaxDb; 10090-ENSMUSP00000118907; -.
DR ProteomicsDB; 345219; -.
DR Ensembl; ENSMUST00000147153.4; ENSMUSP00000118907.2; ENSMUSG00000087303.4.
DR GeneID; 101055671; -.
DR KEGG; mmu:101055671; -.
DR AGR; MGI:3644466; -.
DR CTD; 101055671; -.
DR MGI; MGI:3644466; Lipo2.
DR VEuPathDB; HostDB:ENSMUSG00000087303; -.
DR eggNOG; KOG2624; Eukaryota.
DR GeneTree; ENSGT00940000160031; -.
DR HOGENOM; CLU_010974_0_0_1; -.
DR InParanoid; D3YY49; -.
DR OMA; QYFINSE; -.
DR OrthoDB; 5474043at2759; -.
DR PhylomeDB; D3YY49; -.
DR TreeFam; TF315485; -.
DR BioGRID-ORCS; 101055671; 0 hits in 5 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; D3YY49; Protein.
DR Bgee; ENSMUSG00000087303; Expressed in proximal tubule and 22 other cell types or tissues.
DR Genevisible; D3YY49; MM.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0004771; F:sterol esterase activity; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF13; LIPASE; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR000862};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..398
FT /note="Lipase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013243321"
FT DOMAIN 33..94
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT ACT_SITE 170
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 340
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 369
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 398 AA; 44802 MW; 5DACEC56434C3846 CRC64;
MLWLLRTMCL IQVLGKIFCL FGPKKNPEAH MNVSEIIKHW DYPSEEYEVV TDDGYILPIN
RIPHGKNNAK SPAPKMVVFC QHGLLATPGA WVSNPPVNSL AFILADAGYD VWMGSSRGST
WAKKHVTLNP DSKEFWDFSF DQMIKYDLPA TINFILDKTG QKQIYYIGHS QGTLLAIGAF
ATNQKLAEKI KLNILLAPIY SVQHSKGISH LASYLTPTTI KLLFGEKEFL PTVVFSEVGA
CVCNINFFTA ICAAIMGSMG GYSPEELNKS RLDVYVKLNL AGTSVKVLIH YNQVGRSGIL
QAYDWGSPSL NMRHYNQTTP PVYNVEDMKV PTAMFTGLKD FLSDPEDVEI LKPKIHNLTY
LKTIPDFSHF DFIWGLNTRE EVSEEILTIL RKYDGDYI
//
