ID D3YZZ3_MOUSE Unreviewed; 342 AA.
AC D3YZZ3;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 2.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Mitochondrial amidoxime reducing component 1 {ECO:0000313|Ensembl:ENSMUSP00000106620.3};
GN Name=Mtarc1 {ECO:0000313|Ensembl:ENSMUSP00000106620.3,
GN ECO:0000313|MGI:MGI:1913362};
GN Synonyms=Marc1 {ECO:0000313|MGI:MGI:1913362}, Mosc1
GN {ECO:0000313|MGI:MGI:1913362};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000106620.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000106620.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106620.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000106620.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000106620.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Fe(II)-[cytochrome b5] + 2 H(+) + N(omega)-hydroxy-L-
CC arginine = 2 Fe(III)-[cytochrome b5] + H2O + L-arginine;
CC Xref=Rhea:RHEA:61644, Rhea:RHEA-COMP:10438, Rhea:RHEA-COMP:10439,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033,
CC ChEBI:CHEBI:29034, ChEBI:CHEBI:32682, ChEBI:CHEBI:60107;
CC Evidence={ECO:0000256|ARBA:ARBA00029322};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61645;
CC Evidence={ECO:0000256|ARBA:ARBA00029322};
CC -!- COFACTOR:
CC Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302;
CC Evidence={ECO:0000256|ARBA:ARBA00001924};
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DR AlphaFoldDB; D3YZZ3; -.
DR SMR; D3YZZ3; -.
DR jPOST; D3YZZ3; -.
DR MaxQB; D3YZZ3; -.
DR PeptideAtlas; D3YZZ3; -.
DR ProteomicsDB; 318885; -.
DR Ensembl; ENSMUST00000110992.9; ENSMUSP00000106620.3; ENSMUSG00000026621.14.
DR AGR; MGI:1913362; -.
DR MGI; MGI:1913362; Mtarc1.
DR VEuPathDB; HostDB:ENSMUSG00000026621; -.
DR GeneTree; ENSGT00940000162410; -.
DR OMA; AHDRSFM; -.
DR PhylomeDB; D3YZZ3; -.
DR TreeFam; TF316807; -.
DR ChiTaRS; Marc2; mouse.
DR Proteomes; UP000000589; Chromosome 1.
DR Bgee; ENSMUSG00000026621; Expressed in left lobe of liver and 65 other cell types or tissues.
DR ExpressionAtlas; D3YZZ3; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0030151; F:molybdenum ion binding; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR InterPro; IPR005302; MoCF_Sase_C.
DR InterPro; IPR005303; MOCOS_middle.
DR InterPro; IPR011037; Pyrv_Knase-like_insert_dom_sf.
DR PANTHER; PTHR14237:SF25; MITOCHONDRIAL AMIDOXIME-REDUCING COMPONENT 1; 1.
DR PANTHER; PTHR14237; MOLYBDOPTERIN COFACTOR SULFURASE MOSC; 1.
DR Pfam; PF03473; MOSC; 1.
DR Pfam; PF03476; MOSC_N; 1.
DR SUPFAM; SSF141673; MOSC N-terminal domain-like; 1.
DR SUPFAM; SSF50800; PK beta-barrel domain-like; 1.
DR PROSITE; PS51340; MOSC; 1.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:D3YZZ3,
KW ECO:0007829|PeptideAtlas:D3YZZ3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 27..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 191..340
FT /note="MOSC"
FT /evidence="ECO:0000259|PROSITE:PS51340"
SQ SEQUENCE 342 AA; 38031 MW; 44B9014397419668 CRC64;
MGAGSWALTL FGFSAFRVPG QPRSTWLGVA ALGLAAVALG TVAWRRARPR RRRRLQQVGT
VAQLWIYPIK SCKGLSVSEA ECTAMGLRYG HLRDRFWLVI NEEGNMVTAR QEPRLVLISL
TCEDDTLTLS AAYTKDLLLP ITPPATNPLL QCRVHGLEIQ GRDCGEDAAQ WVSSFLKMQS
CRLVHFEPHM RPRSSRQMKA SGPISQNNEV AYSDASPFLV LSEASLEDLN SRLERRVKAT
NFRPNIVISG CGVYAEDSWN EVLIGDVELK RVMACTRCLL TTVDPDTGIS DRKEPLETLK
SYRLCDPSEQ ALYGKLPIFG QYFALENPGT IRVGDPVYLL GQ
//
