ID D3YZZ5_MOUSE Unreviewed; 224 AA.
AC D3YZZ5;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Transmembrane p24 trafficking protein 7 {ECO:0000313|Ensembl:ENSMUSP00000120904.2};
GN Name=Tmed7 {ECO:0000313|Ensembl:ENSMUSP00000120904.2,
GN ECO:0000313|MGI:MGI:1913926};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000120904.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000120904.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120904.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000120904.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000120904.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004151};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004151}.
CC Golgi apparatus, cis-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004619}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004619}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003827}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003827}.
CC -!- SIMILARITY: Belongs to the EMP24/GP25L family.
CC {ECO:0000256|ARBA:ARBA00007104, ECO:0000256|RuleBase:RU003827}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; NP_079974.1; NM_025698.1.
DR AlphaFoldDB; D3YZZ5; -.
DR SMR; D3YZZ5; -.
DR STRING; 10090.ENSMUSP00000120904; -.
DR iPTMnet; D3YZZ5; -.
DR PhosphoSitePlus; D3YZZ5; -.
DR SwissPalm; D3YZZ5; -.
DR jPOST; D3YZZ5; -.
DR MaxQB; D3YZZ5; -.
DR PaxDb; 10090-ENSMUSP00000120904; -.
DR PeptideAtlas; D3YZZ5; -.
DR ProteomicsDB; 349629; -.
DR TopDownProteomics; D3YZZ5; -.
DR Ensembl; ENSMUST00000151189.2; ENSMUSP00000120904.2; ENSMUSG00000033184.15.
DR GeneID; 66676; -.
DR KEGG; mmu:66676; -.
DR UCSC; uc008evr.2; mouse.
DR AGR; MGI:1913926; -.
DR CTD; 51014; -.
DR MGI; MGI:1913926; Tmed7.
DR VEuPathDB; HostDB:ENSMUSG00000033184; -.
DR eggNOG; KOG1693; Eukaryota.
DR GeneTree; ENSGT00940000158463; -.
DR InParanoid; D3YZZ5; -.
DR OMA; VGEYTFC; -.
DR OrthoDB; 601480at2759; -.
DR PhylomeDB; D3YZZ5; -.
DR TreeFam; TF313000; -.
DR Reactome; R-MMU-6807878; COPI-mediated anterograde transport.
DR Reactome; R-MMU-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR BioGRID-ORCS; 66676; 3 hits in 78 CRISPR screens.
DR ChiTaRS; Tmed7; mouse.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; D3YZZ5; Protein.
DR Bgee; ENSMUSG00000033184; Expressed in seminal vesicle and 261 other cell types or tissues.
DR ExpressionAtlas; D3YZZ5; baseline and differential.
DR Genevisible; D3YZZ5; MM.
DR GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISO:MGI.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0007030; P:Golgi organization; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR Gene3D; 2.60.120.680; GOLD domain; 1.
DR InterPro; IPR015720; Emp24-like.
DR InterPro; IPR009038; GOLD_dom.
DR InterPro; IPR036598; GOLD_dom_sf.
DR PANTHER; PTHR22811; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22811:SF117; TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN 7; 1.
DR Pfam; PF01105; EMP24_GP25L; 1.
DR SMART; SM01190; EMP24_GP25L; 1.
DR SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR PROSITE; PS50866; GOLD; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Proteomics identification {ECO:0007829|EPD:D3YZZ5,
KW ECO:0007829|MaxQB:D3YZZ5};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003827};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..224
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003052559"
FT TRANSMEM 186..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..128
FT /note="GOLD"
FT /evidence="ECO:0000259|PROSITE:PS50866"
SQ SEQUENCE 224 AA; 25201 MW; 1F36B06747AFACA8 CRC64;
MPRPGSAPRW AAAAGRWGCR LLALLLLLPA PSGGSEITFE LPDNAKQCFY EDITQGTKCT
LEFQVITGGH YDVDCRLEDP DGKVLYKEMK KQYDSFTFTA SRNGTYKFCF SNEFSTFTHK
TVYFDFQVGE DPPLFPSENR VSALTQMESA CVSIHEALKS VIDYQTHFRL REAQGRSRAE
DLNTRVAYWS VGEALILLVV SVGQVFLLKS FFSDKRTTTT RVGS
//
