ID D3Z119_MOUSE Unreviewed; 310 AA.
AC D3Z119;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Islet cell autoantigen 1 {ECO:0000313|Ensembl:ENSMUSP00000111180.2};
GN Name=Ica1 {ECO:0000313|Ensembl:ENSMUSP00000111180.2,
GN ECO:0000313|MGI:MGI:96391};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000111180.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000111180.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000111180.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000111180.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000111180.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; D3Z119; -.
DR SMR; D3Z119; -.
DR MaxQB; D3Z119; -.
DR PeptideAtlas; D3Z119; -.
DR ProteomicsDB; 339129; -.
DR Antibodypedia; 1895; 282 antibodies from 28 providers.
DR Ensembl; ENSMUST00000115518.8; ENSMUSP00000111180.2; ENSMUSG00000062995.13.
DR UCSC; uc009axz.1; mouse.
DR AGR; MGI:96391; -.
DR MGI; MGI:96391; Ica1.
DR VEuPathDB; HostDB:ENSMUSG00000062995; -.
DR GeneTree; ENSGT00390000005530; -.
DR ChiTaRS; Ica1; mouse.
DR Proteomes; UP000000589; Chromosome 6.
DR Bgee; ENSMUSG00000062995; Expressed in spermatid and 237 other cell types or tissues.
DR ExpressionAtlas; D3Z119; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0019904; F:protein domain specific binding; IEA:InterPro.
DR CDD; cd07661; BAR_ICA69; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR010504; AH_dom.
DR InterPro; IPR024114; Islet_autoAg_Ica1/Ica1-like.
DR PANTHER; PTHR10164; ISLET CELL AUTOANTIGEN 1; 1.
DR PANTHER; PTHR10164:SF3; ISLET CELL AUTOANTIGEN 1; 1.
DR Pfam; PF06456; Arfaptin; 1.
DR SMART; SM01015; Arfaptin; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR PROSITE; PS50870; AH; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:D3Z119,
KW ECO:0007829|PeptideAtlas:D3Z119};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 50..253
FT /note="AH"
FT /evidence="ECO:0000259|PROSITE:PS50870"
SQ SEQUENCE 310 AA; 36004 MW; 5548CBB5BAEA94CA CRC64;
MSGHKCYSWE LQDRFAQDKS VVNKMQQKYW ETKQAFIKAT GKKEDEHVVA SDADLDAKLE
LFHSIQRTCL DLSKAIVLYQ KRICFLSQEE NELGKFLRSQ GFQDKTRAGK MMQATGKALC
FSSQQRLALR NPLCRFHQEV ETFRHRAISD TWLTVNRMEQ YRTEYRGALL WMKDVSQELD
PDLYKQMEKF RKVQTQVRLA KKNFDKLKMD VCQKVDLLGA SRCNLLSHML ATYQTTLLHF
WEKTSHTMAA IHESFKGYQP YEFTTLKDIT YTLLHGSRAG DSHRGVKWLF PGSATVPFAS
TAIPSLSGSW
//
