ID D3Z5J3_MOUSE Unreviewed; 938 AA.
AC D3Z5J3;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Sorbin and SH3 domain containing 1 {ECO:0000313|Ensembl:ENSMUSP00000097066.4};
GN Name=Sorbs1 {ECO:0000313|Ensembl:ENSMUSP00000097066.4,
GN ECO:0000313|MGI:MGI:700014};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000097066.4, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0007829|PubMed:16452087}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [2] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000097066.4, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097066.4,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5] {ECO:0000313|Ensembl:ENSMUSP00000097066.4}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097066.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_848139.1; NM_178362.1.
DR STRING; 10090.ENSMUSP00000153313; -.
DR PaxDb; 10090-ENSMUSP00000097066; -.
DR ProteomicsDB; 332818; -.
DR Antibodypedia; 30624; 272 antibodies from 31 providers.
DR DNASU; 20411; -.
DR Ensembl; ENSMUST00000099467.10; ENSMUSP00000097066.4; ENSMUSG00000025006.19.
DR Ensembl; ENSMUST00000225153.2; ENSMUSP00000153313.2; ENSMUSG00000025006.19.
DR GeneID; 20411; -.
DR UCSC; uc008hkp.1; mouse.
DR AGR; MGI:700014; -.
DR CTD; 10580; -.
DR MGI; MGI:700014; Sorbs1.
DR VEuPathDB; HostDB:ENSMUSG00000025006; -.
DR GeneTree; ENSGT00940000158658; -.
DR OrthoDB; 5407056at2759; -.
DR TreeFam; TF320680; -.
DR BioGRID-ORCS; 20411; 0 hits in 78 CRISPR screens.
DR ChiTaRS; Sorbs1; mouse.
DR Proteomes; UP000000589; Chromosome 19.
DR Bgee; ENSMUSG00000025006; Expressed in rostral migratory stream and 286 other cell types or tissues.
DR Genevisible; D3Z5J3; MM.
DR CDD; cd11919; SH3_Sorbs1_1; 1.
DR CDD; cd11922; SH3_Sorbs1_2; 1.
DR CDD; cd11916; SH3_Sorbs1_3; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003127; SoHo_dom.
DR InterPro; IPR035606; SORBS1_SH3.
DR InterPro; IPR035610; SORBS1_SH3_1.
DR InterPro; IPR035611; SORBS1_SH3_2.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14167:SF64; SORBIN AND SH3 DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF02208; Sorb; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 3.
DR SMART; SM00459; Sorb; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50002; SH3; 3.
DR PROSITE; PS50831; SOHO; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:D3Z5J3,
KW ECO:0007829|MaxQB:D3Z5J3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 326..429
FT /note="SoHo"
FT /evidence="ECO:0000259|PROSITE:PS50831"
FT DOMAIN 697..756
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 771..832
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 877..938
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..213
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 938 AA; 103977 MW; 1D0AEEB5B7EB2F20 CRC64;
MSSECDVGSS KAVVNGLASG NHGPDKDMDP TKICTGKGTV TLRASSSYRG TPSSSPVSPQ
ESPKHESKSD EWKLSSSADT NGNAQPSPLA AKGYRSVHPS LSADKPQGAT SSSSAPSEVI
VVPLYLVNTD RGQGQEGTAR TPASLGPLGC VHTVPATTPA ASPLTFPTLD DFIPPHLQRR
PHHSQPASAC GSLSPASQTS PPSPPPPLVP PVPEDLHRGL EPDLPGAVSS TGSPLLNEVS
SSHIETDSQD FPPTSRPSSA YPSTTIVNPT IVLLQHNREQ QKRLSSLSDP ASERRAGEQD
PVPTPAELTS PGRASERRAK DASRRVVRST QDLSDVSTDE VGIPLRNTER SKDWYKTMFK
QIHKLNRDTP EENPYFPTYK FPELPEILQN SEEDSSYTPT YQFPASTPSP KSEDDDSDVH
SPRYSFSDDT KSPLSVPRSK SEMNYIEGEK VVKRSATLPL PARSSSLKSS PERNDWEPPD
KKVDTRKYRA EPKSIYEYQP GKSSVLTNEK MSRDISPEEI DLKNEPWYKF FSELEFGRPP
PKKIWDYTPG DCSILPREDR KTNLEKDLSF CQAELEADLE KVETVNKSPS ANSPQSSAVS
PTPDITSEPP GYIYSSNFHA VKRESDGTPG GLASLENERQ IYKSVLEGGD IPLQGLSGLK
RPSSSASTKD SESPRHFIPA DYLESTEEFI RRRHDDKEMR PARAKFDFKA QTLKELPLQK
GDVVYIYRQI DQNWYEGEHH GRVGIFPRTY IELLPPAEKA QPRKLAPVQV LEYGEAIAKF
NFNGDTQVEM SFRKGERITL LRQVDENWYE GRIPGTSRQG IFPITYVDVL KRPLVKTPVD
YIDLPYSSSP SRSATVSPQQ PQAQQRRVTP DRSQPSLDLC SYQALYSYVP QNDDELELRD
GDIVDVMEKC DDGWFVGTSR RTRQFGTFPG NYVKPLYL
//
