ID D3Z9R2_RAT Unreviewed; 393 AA.
AC D3Z9R2;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Methyltransferase 22, Kin17 lysine {ECO:0000313|Ensembl:ENSRNOP00000003700.4};
GN Name=Mettl22 {ECO:0000313|Ensembl:ENSRNOP00000003700.4,
GN ECO:0000313|RGD:1311433};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000003700.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000003700.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003700.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000003700.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003700.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_213210.4; XM_213210.9.
DR AlphaFoldDB; D3Z9R2; -.
DR SMR; D3Z9R2; -.
DR STRING; 10116.ENSRNOP00000003700; -.
DR iPTMnet; D3Z9R2; -.
DR PhosphoSitePlus; D3Z9R2; -.
DR PaxDb; 10116-ENSRNOP00000003700; -.
DR PeptideAtlas; D3Z9R2; -.
DR Ensembl; ENSRNOT00000003700.8; ENSRNOP00000003700.4; ENSRNOG00000002714.8.
DR KEGG; rno:287054; -.
DR UCSC; RGD:1311433; rat.
DR AGR; RGD:1311433; -.
DR CTD; 79091; -.
DR RGD; 1311433; Mettl22.
DR eggNOG; KOG2497; Eukaryota.
DR GeneTree; ENSGT00510000048539; -.
DR HOGENOM; CLU_048361_0_0_1; -.
DR InParanoid; D3Z9R2; -.
DR OMA; AYERIQQ; -.
DR OrthoDB; 450395at2759; -.
DR PhylomeDB; D3Z9R2; -.
DR TreeFam; TF324844; -.
DR Reactome; R-RNO-8876725; Protein methylation.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000002714; Expressed in skeletal muscle tissue and 19 other cell types or tissues.
DR Genevisible; D3Z9R2; RN.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR GO; GO:0031072; F:heat shock protein binding; ISO:RGD.
DR GO; GO:0008276; F:protein methyltransferase activity; ISO:RGD.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR019410; Methyltransf_16.
DR InterPro; IPR038899; METTL22.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR23108:SF0; METHYLTRANSFERASE-LIKE PROTEIN 22; 1.
DR PANTHER; PTHR23108; METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF10294; Methyltransf_16; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT REGION 54..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 43738 MW; 0E3CFCC531F94270 CRC64;
MGPAMDEVTF KSDTVLSDVH LYTPNQRHLM VRLNGMGQPV FLSQFKLLWS QDSWTDSGAE
DNGPRAVSTE ETPPAGSGSG HSHEDLSLQA EDDNTIQEGL SVPLDEDGDL DVVRRPRAAS
DPNPAEPARD KVHPMILEQE EDDLVGDQAR ESCPYSIIKI EHTMATPLED VGKQVWRGAL
LLADYILFRR DLFQGCTVLE LGAGTGLASI VAATMAHTVY CTDVGTDLLA MCQRNVALNR
HLAATGGGVV KVKELDWMKD DLCTDPKVPF SWSEEEIADL YDHTTVLLAA EVFYDDDLTN
ALFHTFSRLV HRLKNACTAI LSVEKRFNFT LRHLDVTCEA YDHFRASLDS LEKLADGRLR
FLVEPVETSF PQLLGYERIQ QLELWKIVVE PAA
//
