ID D3ZAD6_RAT Unreviewed; 1695 AA.
AC D3ZAD6;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Neurexin 2 {ECO:0000313|Ensembl:ENSRNOP00000029449.6};
GN Name=Nrxn2 {ECO:0000313|Ensembl:ENSRNOP00000029449.6,
GN ECO:0000313|RGD:620211};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000029449.6, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000029449.6, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000029449.6,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000029449.6}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000029449.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSRNOT00000031227.8; ENSRNOP00000029449.6; ENSRNOG00000021103.10.
DR RGD; 620211; Nrxn2.
DR VEuPathDB; HostDB:ENSRNOG00000021103; -.
DR GeneTree; ENSGT00940000155978; -.
DR HOGENOM; CLU_001710_1_0_1; -.
DR OrthoDB; 2999458at2759; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000021103; Expressed in frontal cortex and 20 other cell types or tissues.
DR ExpressionAtlas; D3ZAD6; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR15036:SF52; NEUREXIN-2; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1695
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035318205"
FT TRANSMEM 1621..1641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..206
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 202..242
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 279..469
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 476..669
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 673..710
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 715..887
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 901..1076
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1079..1116
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1120..1328
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1441..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1509..1529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1563..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1662..1695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1584
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1679..1695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1695 AA; 183186 MW; 01B91AC6F761FD65 CRC64;
MALGSRWRPP PQLPPLLLLL ALVAGVRGLE FGGGPGQWAR YARWAGAAST GELSFSLRTN
ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT LQLDTPVADD RWHMVLLTRD
ARRTALAVDG EARAAEVRSK RREMQVASDL FVGGIPPDVR LSALTLSTVK YEPPFRGLLA
NLKLGERPPA LLGSQGLRGA AADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF
CSEEEHPMEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY DLSHNPIQSS
TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI NLGSGAFEAL VEPVNGKFND
NAWHDVRVTR NLRQHAGIGH AMVTISVDGI LTTTGYTQED YTMLGSDDFF YIGGSPNTAD
LPGSPVSNNF MGCLKDVVYK NNDFKLELSR LAKEGDPKMK LQGDLSFRCE DVAALDPVTF
ESPEAFVALP RWSAKRTGSI SLDFRTTEPN GLLLFSQGRR AGAGVGSHSS SQRADYFAME
LLDGYLYLLL DMGSGGIKLR ASSRKVNDGE WCHVDFQRDG RKGSISVNSR STPFLATGES
EVLDLESELY LGGLPEGGRV DLPLPPEVWT AALRAGYVGC VRDLFIDGRS RDLRGLAEAQ
GAVGVAPFCS RETLKQCASA PCRNGGICRE GWNRFVCDCI GTGFLGRVCE REATVLSYDG
SMYMKIMLPN AMHTEAEDVS LRFMSQRAYG LMMATTSRES ADTLRLELDG GQMKLTVNLD
CLRVGCAPSK GPETLFAGHK LNDNEWHTVR VVRRGKSLQL SVDNVTVEGQ MAGAHTRLEF
HNIETGIMTE RRFISVVPSN FIGHLSGLVF NGQPYMDQCK DGDITYCELN ARFGLRAIVA
DPVTFKSRSS YLALATLQAY ASMHLFFQFK TTAPDGLLLF NSGNGNDFIV IELVKGYIHY
VFDLGNGPSL MKGNSDKPVN DNQWHNVVVS RDPGNVHTLK IDSRTVTQHS NGARNLDLKG
ELYIGGLSKN MFSNLPKLVA SRDGFQGCLA SVDLNGRLPD LIADALHRIG QVERGCDGPS
TTCTEESCAN QGVCLQQWDG FTCDCTMTSY GGPVCNDPGT TYIFGKGGAL ITYTWPPNDR
PSTRMDRLAV GFSTHQRSAV LVRVDSASGL GDYLQLHIDQ GTVGVIFNVG TDDITIDEPN
AIVSDGKYHV VRFTRSGGNA TLQVDSWPVN ERYPAGNFDN ERLAIARQRI PYRLGRVVDE
WLLDKGRQLT IFNSQAAIKI GGRDQGRPFQ GQVSGLYYNG LKVLALAAES DPNVRTEGHL
RLVGEGPSVL LSAETTATTL LADMATTIME TTTTMATTTT RRGRSPTMRD STTQNTDDLL
VASAECPSDD EDLEECEPST GGELILPIIT EDSLDPPPVA TRSPFVPPPP TFYPFLTGVG
ATQDTLPPPA ARRPSSGGPC QAERDDSDCE EPVEASGFAS GEVFDSSLPP TDDEDFYTTF
PLVTDRTTLL SPRKPAPRPN LRTDGATGAP GVLLAPSAPA PNLPAGKMNH RDPLQPLLEN
PPLGPGVPTA FEPRRPPPLR PGVTSVPGFP RLPTANPTGP GERGPPGAVE VIRESSSTTG
MVVGIVAAAA LCILILLYAM YKYRNRDEGS YQVDQSRNYI SNSAQSNGAV VKEKAPAAPK
TPSKAKKNKD KEYYV
//
