ID D3ZD71_RAT Unreviewed; 648 AA.
AC D3ZD71;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=EF-hand domain containing 1 {ECO:0000313|Ensembl:ENSRNOP00000017393.4};
GN Name=Efhc1 {ECO:0000313|Ensembl:ENSRNOP00000017393.4,
GN ECO:0000313|RGD:1587365};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000017393.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000017393.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000017393.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000017393.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000017393.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
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DR RefSeq; NP_001116419.2; NM_001122947.2.
DR AlphaFoldDB; D3ZD71; -.
DR SMR; D3ZD71; -.
DR STRING; 10116.ENSRNOP00000017393; -.
DR iPTMnet; D3ZD71; -.
DR PhosphoSitePlus; D3ZD71; -.
DR PaxDb; 10116-ENSRNOP00000017393; -.
DR Ensembl; ENSRNOT00000017393.8; ENSRNOP00000017393.4; ENSRNOG00000042729.4.
DR GeneID; 301295; -.
DR KEGG; rno:301295; -.
DR UCSC; RGD:1587365; rat.
DR AGR; RGD:1587365; -.
DR CTD; 114327; -.
DR RGD; 1587365; Efhc1.
DR eggNOG; KOG0043; Eukaryota.
DR GeneTree; ENSGT00530000063528; -.
DR HOGENOM; CLU_018366_0_1_1; -.
DR InParanoid; D3ZD71; -.
DR OMA; RYNVESS; -.
DR OrthoDB; 160134at2759; -.
DR PhylomeDB; D3ZD71; -.
DR TreeFam; TF314504; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000042729; Expressed in testis and 19 other cell types or tissues.
DR Genevisible; D3ZD71; RN.
DR GO; GO:0005879; C:axonemal microtubule; ISO:RGD.
DR GO; GO:0005930; C:axoneme; ISO:RGD.
DR GO; GO:0005813; C:centrosome; ISO:RGD.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0072686; C:mitotic spindle; ISO:RGD.
DR GO; GO:0043025; C:neuronal cell body; ISO:RGD.
DR GO; GO:0000922; C:spindle pole; ISO:RGD.
DR GO; GO:0043014; F:alpha-tubulin binding; ISO:RGD.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0021795; P:cerebral cortex cell migration; ISO:RGD.
DR GO; GO:0060285; P:cilium-dependent cell motility; IBA:GO_Central.
DR GO; GO:0000281; P:mitotic cytokinesis; ISO:RGD.
DR GO; GO:0007052; P:mitotic spindle organization; ISO:RGD.
DR GO; GO:0051302; P:regulation of cell division; ISO:RGD.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 2.30.29.170; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR040193; EFHC1/EFHC2/EFHB.
DR PANTHER; PTHR12086; EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12086:SF9; EF-HAND DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF06565; DM10_dom; 3.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00676; DM10; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS51336; DM10; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 93..198
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 239..359
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 416..520
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
FT DOMAIN 582..617
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 648 AA; 74901 MW; E22417F89087DD82 CRC64;
MVTNPVHGLP LLPGSSFTDS TKTAFHRSQT LGYRNGYAFV RRPTMGIGGD RLPYNQLSPA
ELDELANKAP ILTYGPLKQA APAEFVPAHV AFDKKVLKFS AYFQEDVPIS MEEHYRIRRV
NIYYYLEDDS MSVIEPVVEN SGIPQGKLVK RQRLAKNDVG DHYHWKDLNR GINLTIYGKT
FRIVDCDRFT QDFLESQGIE LNPSEKMPLD PYTELRKEPV RKYVTPSDFD QLKQFLTFDK
QVLRFYAIWD DTDSLFGECR HYIIHYYLMD DTVEIREVHE RNNGRDPFPL LMNRQRMPKV
LVDNGKNFPQ CVLEISDQEV LEWYTAKDFI VGKPLTILGR TFFIYDCDPF TRQFYKDKFG
MSDLPRVDVS KKEPPPVKQE LPPYNGYGLI EDSAQNCFAL VPKAPRKDIV KMLMNDNKVL
RYLAALESPI PEDKDRRFVF SYFLATDMIS IFEPPVRNSG IIGGKFLGRT KVVKSFSPVD
NPIYYGPSDF FIGAVIEVFG HRFVILDTDE YVLKYMESNA SQYSPEALAS IQNRIRKQDS
PAPELECKQA TEETKALATE ELKAQGLDKL IEKIQMHLKD ISCKDNLRER FQVYDKEESG
YVDKETFFKV CETLNVPVDD SLIKELIRLC THGEGRINYY NFVRAFSD
//
