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Database: UniProt
Entry: D3ZE17_RAT
LinkDB: D3ZE17_RAT
Original site: D3ZE17_RAT 
ID   D3ZE17_RAT              Unreviewed;      1430 AA.
AC   D3ZE17; F1LS31;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   26-FEB-2020, entry version 78.
DE   SubName: Full=Caskin-1 {ECO:0000313|Ensembl:ENSRNOP00000039956};
GN   Name=Caskin1 {ECO:0000313|Ensembl:ENSRNOP00000039956,
GN   ECO:0000313|RGD:620191};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000039956, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000039956, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039956,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000039956}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000039956};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
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DR   EMBL; AC103090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_542421.2; NM_080690.2.
DR   SMR; D3ZE17; -.
DR   Ensembl; ENSRNOT00000004486; ENSRNOP00000004486; ENSRNOG00000003195.
DR   Ensembl; ENSRNOT00000043951; ENSRNOP00000039956; ENSRNOG00000003195.
DR   GeneID; 140722; -.
DR   KEGG; rno:140722; -.
DR   CTD; 57524; -.
DR   RGD; 620191; Caskin1.
DR   eggNOG; KOG0507; Eukaryota.
DR   eggNOG; COG0666; LUCA.
DR   GeneTree; ENSGT00940000158025; -.
DR   HOGENOM; CLU_003619_1_1_1; -.
DR   KO; K21952; -.
DR   OMA; QEDGQGP; -.
DR   OrthoDB; 75723at2759; -.
DR   TreeFam; TF320582; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000003195; Expressed in brain and 9 other tissues.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR   CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR   CDD; cd12062; SH3_Caskin1; 1.
DR   Gene3D; 1.10.150.50; -; 2.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR027013; Caskin-1/2.
DR   InterPro; IPR032232; Caskin1-CID.
DR   InterPro; IPR035497; Caskin1/2_SAM_1.
DR   InterPro; IPR035498; Caskin1/2_SAM_2.
DR   InterPro; IPR035495; Caskin1_SH3.
DR   InterPro; IPR032117; Caskin_C.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR24174:SF11; PTHR24174:SF11; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF16632; Caskin-tail; 1.
DR   Pfam; PF16600; Caskin1-CID; 1.
DR   Pfam; PF00536; SAM_1; 2.
DR   Pfam; PF07653; SH3_2; 1.
DR   PRINTS; PR01415; ANKYRIN.
DR   SMART; SM00248; ANK; 6.
DR   SMART; SM00454; SAM; 2.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF47769; SSF47769; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 6.
DR   PROSITE; PS50105; SAM_DOMAIN; 2.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00752027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Repeat {ECO:0000256|SAAS:SAAS00752241};
KW   SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192}.
FT   DOMAIN          41..289
FT                   /note="ANK_REP_REGION"
FT                   /evidence="ECO:0000259|PROSITE:PS50297"
FT   REPEAT          48..80
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          81..113
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          114..146
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          147..171
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          188..220
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          220..252
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   DOMAIN          281..347
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          474..537
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          543..607
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   REGION          348..372
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          421..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          667..1000
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1015..1040
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1055..1371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1388..1407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        684..725
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        774..789
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        843..863
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        872..898
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        970..984
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1144..1159
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1187..1232
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1266..1284
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1301..1315
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1322..1339
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1430 AA;  150266 MW;  EE8A81A8F557B032 CRC64;
     MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDPDGF SALHHAALNG
     NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL VLKAGSAVNV PSDEGHIPLH
     LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT PLDLACEFGR VGVVQLLLSS NMCAALLEPR
     PGDTTDPNGT SPLHLAAKNG HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL
     LDSGINAQVR NTYSQTALDI VHQFTTSQAS KEIKQLLREA SAALQVRATK DYCNNYDLTS
     LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG SRTGSEPSPP
     QGGGSLGPSA PPEEIWVLRK PFAGGDRSGS LSNVAGGRST GGHALHAGAE GVKLLATVLS
     QKSVSESSPG DSPVKPPEGS SGAARSQPPA AHAGQVYGEQ PPKKLESSSA SEGKSAEAVS
     QWLATFQLQL YAPNFTSAGY DLPTISRMTP EDLTAIGVTK PGHRKKITAE ISGLNIPDCL
     PEHKPANLAV WLSMIGLAQY YKVLVDNGYE NIDFITDITW EDLQEIGITK LGHQKKLMLA
     VRKLAELQKA EYSKYEGGPL RRKAPQSLEM MAIESPPPSE PAAAECQSPK MTTFQDSELS
     GELQAALSGP AEAGAAAAEK SSNHLPATPR TTSRQESSLS GRARHMSSSQ ELLGDGPQGP
     GSPMSRSQEY LLDEGPAPGT PPKEVRSSRH GHSVKRASVP PVPGKPRQVL PSGVSHFTPP
     QTPTKAQPGS PQALGGPHGP ATAKVKPTPQ LLPPTDRPMS PRSLPQSPTH RGFAYVLPQP
     VEGEAGPPAP GPVPPPVPAA VPTLCLPPEA DVEPGRPKKR AHSLNRYAAS DSEPERDELL
     VPAAAGPYAT VQRRVGRSHS VRAPAGTDKN VNRSQSFAVR PRKKGPPPPP PKRSSSAMAS
     ANLADEPSPD VETEDGRLGV RAQRRRASDL AGSVDTGSAG SVKSIAAMLE LSSIGGGGRA
     IRRPPEGHPT PRPASPDPGR VATVLASVKH KEAIGPDGEV VNRRRTLSGP VTGLLATARR
     GPGEPAEQSH FMEDGTARQR LRGPAKGEAG VEGPPLARVE ASATLKRRIR AKQSQQENVK
     FILTESDTVK RRPKAKEPDI GPEPPPPLSV YQNGTATIRR RPASEQAGPP ELPPPPPPAE
     PPPTDLMPLP PLPLPDGSAR KPVKPPVSPK PILAQPVSKI QGSPTPASKK VPLPGPGSPE
     VKRAHGTPPP VSPKPPPPPT APKPAKALAG LQSSSATPSP VPSPARQPPA ALIKPASSPP
     SQSASPAKPP SPGAPALQVP TKPPRAAASV VSGPPVASDC ASPGDSARQK LEETSACLAA
     ALQAVEEKIR QEDGQGPRPS SIEEKSTGSI LEDIGSMFDD LADQLDAMLE
//
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