ID D3ZEN8_RAT Unreviewed; 258 AA.
AC D3ZEN8; A0A3B0IZ33;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Adiponectin l {ECO:0000313|EMBL:SOR70296.1};
DE SubName: Full=Complement C1q like 1 {ECO:0000313|Ensembl:ENSRNOP00000003986.6};
GN Name=C1ql1 {ECO:0000313|Ensembl:ENSRNOP00000003986.6,
GN ECO:0000313|RGD:1306039}; Synonyms=Adil {ECO:0000313|EMBL:SOR70296.1};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000003986.6, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000003986.6, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003986.6,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|EMBL:SOR70296.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30003153; DOI=10.1016/j.heliyon.2018.e00647;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian adiponectin genes.";
RL Heliyon 4:e00647-e00647(2018).
RN [3] {ECO:0000313|EMBL:SOR70296.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [4] {ECO:0000313|Ensembl:ENSRNOP00000003986.6}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000003986.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; LT963078; SOR70296.1; -; Genomic_DNA.
DR RefSeq; NP_001102308.1; NM_001108838.1.
DR STRING; 10116.ENSRNOP00000003986; -.
DR PaxDb; 10116-ENSRNOP00000003986; -.
DR Ensembl; ENSRNOT00000003986.6; ENSRNOP00000003986.6; ENSRNOG00000002963.6.
DR GeneID; 363686; -.
DR KEGG; rno:363686; -.
DR UCSC; RGD:1306039; rat.
DR AGR; RGD:1306039; -.
DR CTD; 10882; -.
DR RGD; 1306039; C1ql1.
DR VEuPathDB; HostDB:ENSRNOG00000002963; -.
DR eggNOG; ENOG502QSKV; Eukaryota.
DR GeneTree; ENSGT00940000162478; -.
DR HOGENOM; CLU_001074_3_1_1; -.
DR OMA; GIDGHYE; -.
DR OrthoDB; 4210331at2759; -.
DR TreeFam; TF329591; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000002963; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0150053; C:cerebellar climbing fiber to Purkinje cell synapse; ISO:RGD.
DR GO; GO:0044301; C:climbing fiber; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0098793; C:presynapse; ISO:RGD.
DR GO; GO:0043083; C:synaptic cleft; ISO:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0099558; P:maintenance of synapse structure; ISO:RGD.
DR GO; GO:0061743; P:motor learning; ISO:RGD.
DR GO; GO:0016322; P:neuron remodeling; ISO:RGD.
DR GO; GO:1905806; P:regulation of synapse pruning; ISO:RGD.
DR Gene3D; 2.60.120.40; -; 1.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR InterPro; IPR001073; C1q_dom.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR22923:SF64; C1Q-RELATED FACTOR; 1.
DR PANTHER; PTHR22923; CEREBELLIN-RELATED; 1.
DR Pfam; PF00386; C1q; 1.
DR Pfam; PF01391; Collagen; 1.
DR PRINTS; PR00007; COMPLEMNTC1Q.
DR SMART; SM00110; C1Q; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50871; C1Q; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..258
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041156986"
FT DOMAIN 125..258
FT /note="C1q"
FT /evidence="ECO:0000259|PROSITE:PS50871"
FT REGION 39..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 258 AA; 26500 MW; 3C769203069B2137 CRC64;
MLLVLVVLIP VLVSSGGPDG HYEMLGTCRM VCDPYPARGP GAGARSDGGD ALSEQSGAPP
PSTLVQGPQG KPGRTGKPGP PGPPGDRGPP GPVGPPGEKG EPGKPGPPGL PGSGGSGAIS
TATYTTVPRV AFYAGLKNPH EGYEVLKFDD VVTNLGNNYD AASGKFTCNI PGTYFFTYHV
LMRGGDGTSM WADLCKNGQV RASAIAQDAD QNYDYASNSV ILHLDAGDEV FIKLDGGKAH
GGNSNKYSTF SGFIIYSD
//
