ID D3ZF82_RAT Unreviewed; 541 AA.
AC D3ZF82;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Tubulin tyrosine ligase like 2 {ECO:0000313|Ensembl:ENSRNOP00000043132.4};
GN Name=Ttll2 {ECO:0000313|Ensembl:ENSRNOP00000043132.4,
GN ECO:0000313|RGD:1305200};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000043132.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000043132.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043132.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000043132.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043132.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR RefSeq; XP_006227981.1; XM_006227919.3.
DR RefSeq; XP_006227983.1; XM_006227921.3.
DR RefSeq; XP_008756973.1; XM_008758751.2.
DR AlphaFoldDB; D3ZF82; -.
DR SMR; D3ZF82; -.
DR STRING; 10116.ENSRNOP00000043132; -.
DR PaxDb; 10116-ENSRNOP00000043132; -.
DR Ensembl; ENSRNOT00000044831.5; ENSRNOP00000043132.4; ENSRNOG00000033901.5.
DR GeneID; 292311; -.
DR AGR; RGD:1305200; -.
DR CTD; 83887; -.
DR RGD; 1305200; Ttll2.
DR eggNOG; KOG2157; Eukaryota.
DR GeneTree; ENSGT00940000162752; -.
DR HOGENOM; CLU_010131_9_0_1; -.
DR InParanoid; D3ZF82; -.
DR OMA; GLDAHDC; -.
DR OrthoDB; 7265at2759; -.
DR TreeFam; TF313087; -.
DR Reactome; R-RNO-8955332; Carboxyterminal post-translational modifications of tubulin.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000033901; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF118; TUBULIN POLYGLUTAMYLASE TTLL2-RELATED; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 541 AA; 61960 MW; C0F2DAF559491B39 CRC64;
MMNGLQTLGD VTAEIFRLSP EGNTVQKRQR LRMEDEAPGA ALKPLVFRVD ESTPGVVQSV
LLERGWDKFD EQCQDVEDWN LYWRSSSFRM AEYVNIKPWQ RLNHHPGTTS LTRKDCLAKH
LAHMRRLYGE SIYEFTPLTF IMPSDYTKFV AKYFKEKQDL GTKPSYWICK PAKLSQGRGI
IIFSDIRDLM FKDAYVVQKY ICNPLLVGRY KCDLRIYVCV TGFKPLTIYM YQEGLVRFAT
EKFDLSNLED YYSHLTNSSI NKLGASYEKI KEVVGQGCKW TLSRFFSYLR NWDVDDLLLR
RKINHMVILT VLAMAPSVPV ANNCFELFGF DILIDDNLKP WLLEVNYSPA LSLECSTDVS
VKRSLVHDII ELLYLNGLRS EEKKCGRTSQ GNAMVSQARR SQQKLCAAPA PPSYASLIQF
ATCSKRSPAA QHMCPKHTRT SQLREMLCRQ NKLLTREAAK SKPRLKAWHS PRKMLSLCAS
QSLPRKTKGP TGILPEAGNT PNNHAGNFVL IFPFNKATFS ASRNGLNVKR IIQELQKLMN
K
//
