ID D3ZGB8_RAT Unreviewed; 1184 AA.
AC D3ZGB8;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Cartilage intermediate layer protein {ECO:0000313|Ensembl:ENSRNOP00000048194.5};
GN Name=Cilp {ECO:0000313|Ensembl:ENSRNOP00000048194.5,
GN ECO:0000313|RGD:1305124};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000048194.5, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000048194.5, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000048194.5,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000048194.5}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000048194.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; NP_001101631.1; NM_001108161.1.
DR AlphaFoldDB; D3ZGB8; -.
DR STRING; 10116.ENSRNOP00000048194; -.
DR PhosphoSitePlus; D3ZGB8; -.
DR PaxDb; 10116-ENSRNOP00000048194; -.
DR Ensembl; ENSRNOT00000044887.5; ENSRNOP00000048194.5; ENSRNOG00000029911.5.
DR GeneID; 315761; -.
DR KEGG; rno:315761; -.
DR UCSC; RGD:1305124; rat.
DR AGR; RGD:1305124; -.
DR CTD; 8483; -.
DR RGD; 1305124; Cilp.
DR VEuPathDB; HostDB:ENSRNOG00000029911; -.
DR eggNOG; ENOG502QQ8H; Eukaryota.
DR GeneTree; ENSGT00390000008152; -.
DR HOGENOM; CLU_008073_0_0_1; -.
DR OMA; RAETPYM; -.
DR TreeFam; TF330132; -.
DR Reactome; R-RNO-2404192; Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000029911; Expressed in esophagus and 17 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR GO; GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; ISO:RGD.
DR GO; GO:0060392; P:negative regulation of SMAD protein signal transduction; ISO:RGD.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR013784; Carb-bd-like_fold.
DR InterPro; IPR039675; CILP1/CILP2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR025155; WxxW_domain.
DR PANTHER; PTHR15031:SF3; CARTILAGE INTERMEDIATE LAYER PROTEIN 1; 1.
DR PANTHER; PTHR15031; CARTILAGE INTERMEDIATE LAYER PROTEIN CLIP; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13330; Mucin2_WxxW; 1.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF49452; Starch-binding domain-like; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
SQ SEQUENCE 1184 AA; 132148 MW; 8FF7F3E792AA84BC CRC64;
MAATKTWVLS FLVLEVTTVL GRQMMLTQSA RRVQPVKRTP KILTKPVNSQ ESPGEWTTWF
NIDHPGGQGD YERLDAIRFY YGERVCARPL RLEARTTDWM PAGITGQVVH GSPREGFWCL
NKEQRPGQNC SNYTVRFLCP PGSLRRDTEH IWSSWSPWSA CSAACGHTGV QTRTRTCLAQ
TVSLCNEATE EGQLCMSQAC TACDLTCPMG QVNADCDACM CQDFMLHGAI SLPGGGPAPG
ATVYLLAKAP KMLTQTDSSG SFRVPGLCPD GKTVLKVTKS KFAPIMITMP KTSLKSATIN
AEFVRAETPY IVMNPETKAR RAGQSVSLCC KATGKPSPDK YFWYHNNTLL DPSLYKHQSK
LVLRNLQQDQ AGEYFCKAQS DAGAVKSKVT QLTVIAHDEA PCNPTPESYL IRLPHDCFQN
ATNSFYYDVG RCPIKTCAGQ QDNGIRCQDA VENCCGISRT EEREIQCSGY TLPTKVAMEC
SCQRCAETRS IVRGRVTAAD DGEPMRFGHV YMGNNRVSMT GYKGTFTLHV PQDTERLVLT
FVDRLQKFVN TTKVLPFNKK GSAVFHEIKM LRQKEPITLE ATETNIIPLG EVAGEDPVAE
LEIPPKSFYK QNGEPFTGKV KASVTFLDPR NVSTATATQS DLNFINDEGD TFPLRTYGMF
SVDFRDEATS ESLNAGKVKV HLDSTQVKMP EHARAMKLWS LNPNTGLWEE EGDFKFESQR
RNKREERTFL VGNMEIRERR LFNLDVPESR RCFIKVRTYR SERFLPSEQI QGVVVSVINL
EPRTGFSSNP RAWGRFDSVI TGPNGACLPA FCDDQSPDAY SVYVLASLSG EELEAVESSP
KFNPNAIGVP QPYLNKLKYR RTDHEDPRVK KTAFQISMAK PRPNSAEESN GPIYAFENLR
ACEEAPPSAA HFRFYQIEGD RYDYNTVPFN EDDPMSWTED YLAWWPKPME FRACYIKVKI
VGPLEVNVRS RNMGGTHRQT VGKLYGIRDV KSTRDRDQPN VSSACLEFKC SGMLYDQDRV
DRTLVKVIPQ GSCHRASVNS MLHEYLVNHL PLAVNNDTSE YTMLAPLDPL GHNYGIYTVT
DQDPGTAKEI ALGRCFDGTS DGSSRIMKSN VGVALTFNCA ERQVGRQSAF QYLQSTPARS
PATGTVQGRV PAMRQQRASR GGLRRRGSMA PLRFSGVAQQ PLSN
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