ID D3ZGN3_RAT Unreviewed; 184 AA.
AC D3ZGN3;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=DAN domain BMP antagonist family member 5 {ECO:0000313|Ensembl:ENSRNOP00000043790.1};
GN Name=Dand5 {ECO:0000313|Ensembl:ENSRNOP00000043790.1,
GN ECO:0000313|RGD:1590249};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000043790.1, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000043790.1, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043790.1,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000043790.1}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000043790.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR027807}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|PIRNR:PIRNR027807}.
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DR RefSeq; XP_001064979.1; XM_001064979.4.
DR RefSeq; XP_002725448.1; XM_002725402.4.
DR AlphaFoldDB; D3ZGN3; -.
DR SMR; D3ZGN3; -.
DR STRING; 10116.ENSRNOP00000043790; -.
DR PhosphoSitePlus; D3ZGN3; -.
DR PaxDb; 10116-ENSRNOP00000043790; -.
DR Ensembl; ENSRNOT00000044133.2; ENSRNOP00000043790.1; ENSRNOG00000033368.2.
DR GeneID; 685719; -.
DR KEGG; rno:685719; -.
DR AGR; RGD:1590249; -.
DR CTD; 199699; -.
DR RGD; 1590249; Dand5.
DR eggNOG; ENOG502RZ3T; Eukaryota.
DR GeneTree; ENSGT00530000063926; -.
DR HOGENOM; CLU_122900_0_0_1; -.
DR InParanoid; D3ZGN3; -.
DR OMA; PVVLWCR; -.
DR OrthoDB; 5347549at2759; -.
DR PhylomeDB; D3ZGN3; -.
DR TreeFam; TF106445; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000033368; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016015; F:morphogen activity; ISO:RGD.
DR GO; GO:0003283; P:atrial septum development; ISO:RGD.
DR GO; GO:0061371; P:determination of heart left/right asymmetry; ISO:RGD.
DR GO; GO:0003140; P:determination of left/right asymmetry in lateral mesoderm; ISO:RGD.
DR GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISO:RGD.
DR GO; GO:1900108; P:negative regulation of nodal signaling pathway; ISO:RGD.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR GO; GO:0035582; P:sequestering of BMP in extracellular matrix; IBA:GO_Central.
DR GO; GO:0038101; P:sequestering of nodal from receptor via nodal binding; ISO:RGD.
DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IBA:GO_Central.
DR GO; GO:0003281; P:ventricular septum development; ISO:RGD.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR016860; Cerberus.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR PANTHER; PTHR15273; DAN DOMAIN FAMILY MEMBER 5; 1.
DR PANTHER; PTHR15273:SF5; DAN DOMAIN FAMILY MEMBER 5; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF027807; Cerberus; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR027807};
KW Signal {ECO:0000256|PIRNR:PIRNR027807}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT CHAIN 24..184
FT /evidence="ECO:0000256|PIRNR:PIRNR027807"
FT /id="PRO_5024527567"
FT DOMAIN 84..181
FT /note="DAN"
FT /evidence="ECO:0000259|Pfam:PF03045"
SQ SEQUENCE 184 AA; 19536 MW; 78EACE52B4EF9202 CRC64;
MLRGQLTTLL GLLSGAWLPT GSGIPRAPAT PAQSWAATNQ SRTLDPLVPI SALGSWKAFL
GLQNKQQGTG EPQGGQSVAA GVPLPLAPQE LLQETCKALP FVQVISRPGC TSARVLNHLC
FGHCSSFYIP SSDPSPVVLC NSCVPSRRRW TSVALWCGAG QSASPRRVRI STVLVQKCQC
HPRL
//
