ID D3ZHZ3_RAT Unreviewed; 886 AA.
AC D3ZHZ3;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 2.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=Osbpl3 {ECO:0000313|Ensembl:ENSRNOP00000013828.5,
GN ECO:0000313|RGD:1564287};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000013828.5, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000013828.5, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000013828.5,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000013828.5}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000013828.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR RefSeq; XP_001055606.3; XM_001055606.5.
DR RefSeq; XP_006224981.1; XM_006224919.3.
DR RefSeq; XP_006224982.1; XM_006224920.3.
DR RefSeq; XP_006224983.1; XM_006224921.3.
DR RefSeq; XP_006224984.1; XM_006224922.2.
DR RefSeq; XP_006236577.1; XM_006236515.3.
DR RefSeq; XP_006236578.1; XM_006236516.3.
DR RefSeq; XP_006236579.1; XM_006236517.3.
DR RefSeq; XP_006236580.1; XM_006236518.2.
DR RefSeq; XP_017448483.1; XM_017592994.1.
DR RefSeq; XP_017458284.1; XM_017602795.1.
DR RefSeq; XP_342684.5; XM_342683.8.
DR AlphaFoldDB; D3ZHZ3; -.
DR SMR; D3ZHZ3; -.
DR STRING; 10116.ENSRNOP00000013828; -.
DR iPTMnet; D3ZHZ3; -.
DR PhosphoSitePlus; D3ZHZ3; -.
DR jPOST; D3ZHZ3; -.
DR PaxDb; 10116-ENSRNOP00000013828; -.
DR PeptideAtlas; D3ZHZ3; -.
DR Ensembl; ENSRNOT00000013828.9; ENSRNOP00000013828.5; ENSRNOG00000010011.9.
DR GeneID; 362360; -.
DR KEGG; rno:362360; -.
DR AGR; RGD:1564287; -.
DR CTD; 26031; -.
DR RGD; 1564287; Osbpl3.
DR eggNOG; KOG1737; Eukaryota.
DR GeneTree; ENSGT00940000155957; -.
DR HOGENOM; CLU_007105_4_1_1; -.
DR InParanoid; D3ZHZ3; -.
DR OMA; XAKYWST; -.
DR OrthoDB; 960at2759; -.
DR TreeFam; TF320922; -.
DR Reactome; R-RNO-192105; Synthesis of bile acids and bile salts.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000010011; Expressed in stomach and 19 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0031965; C:nuclear membrane; ISO:RGD.
DR GO; GO:0097038; C:perinuclear endoplasmic reticulum; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0015485; F:cholesterol binding; ISO:RGD.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Proteomics identification {ECO:0007829|PeptideAtlas:D3ZHZ3};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 50..145
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 817..844
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 100574 MW; 9D6006CFD3C353C8 CRC64;
MSDEKNLGVS QKLVSPSRST SSCSSKQGSR QDSWEVVEGL RGEMTYTQEP PAQKGFLLKK
RKWPLKGWHK RFFCLEKGIL KYAKSQTDIE REKLHGSIDV GLSVMSVKKS SKCIDLDTEE
HIYHLKVKSE DVFDEWVSKL RHHRMYRQNE IAMFPRDVNH FFPGSSVTDS APGVFESVSS
RKRSSLSKQN SFPAGSNLSF SCGGDTRVPF WLQSSEDMEK CSKDLAHCHT YLLEMSQLLE
SMDVLHRTYS APAINAIQGG AFESPKKEKR SHRRWRSRAI GKDAKGMLQV PKPFSGPVRL
HSSNPNLSTL DFGEEKSYSD GSEASSEFSK MQEDLCHVAH KVYFALRSAF NSISMEREKL
KQLMELDTSS SPSAQVVGLK HALSSALAQN TDLKERLRRI HAESLLLDPP AGPKPGDNLA
EEISRDESRA LVHQLSNESR LSITDSLSEF FDAQEVLLSP SSSENEISDD DSYVSDISDN
LSLDNLSNDL DNERQTLGPV LESSGEARSK RRTSLPAPGP NTSSVSVWSI LRNNIGKDLS
KVAMPVELNE PLNTLQRLCE ELEYSELLDK AAHMPSPLER MVYVAAFAIS AYASSYFRAG
SKPFNPVLGE TYECIRQDKG FQFFAEQVSH HPPISACHAE SRNFVFWQDV RWKNKFWGKS
MEIVPIGTTH VTLPAFGDHF EWNKVTSCIH NILSGQRWIE HYGEIVIKNL RDDSCHCKVN
FIKAKYWSTN AHEIEGTVFD RSGKAVHRLF GKWHESIYCG GASSSTCVWR ANPMPKGYEQ
YYGFTQFALE LNEMDPLSRS LLPPTDTRFR PDQRLLEEGN IEEAEVQKQR IEKLQRERRR
VLEENGVEHQ PRFFRKSSDD AWVSNGTYLE LRKDLGFSKL DHPVLW
//
