ID D3ZM69_RAT Unreviewed; 996 AA.
AC D3ZM69;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 2.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Erythrocyte membrane protein band 4.1-like 2 {ECO:0000313|Ensembl:ENSRNOP00000058049.3};
GN Name=Epb41l2 {ECO:0000313|Ensembl:ENSRNOP00000058049.3,
GN ECO:0000313|RGD:1563977};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000058049.3, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000058049.3, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058049.3,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000058049.3}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000058049.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_017443277.1; XM_017587788.1.
DR RefSeq; XP_017445345.1; XM_017589856.1.
DR AlphaFoldDB; D3ZM69; -.
DR SMR; D3ZM69; -.
DR IntAct; D3ZM69; 1.
DR STRING; 10116.ENSRNOP00000058049; -.
DR PaxDb; 10116-ENSRNOP00000058049; -.
DR Ensembl; ENSRNOT00000061332.6; ENSRNOP00000058049.3; ENSRNOG00000012346.9.
DR AGR; RGD:1563977; -.
DR RGD; 1563977; Epb41l2.
DR eggNOG; KOG3527; Eukaryota.
DR GeneTree; ENSGT00940000155617; -.
DR OrthoDB; 5391231at2759; -.
DR Reactome; R-RNO-6794361; Neurexins and neuroligins.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000012346; Expressed in lung and 18 other cell types or tissues.
DR ExpressionAtlas; D3ZM69; baseline and differential.
DR GO; GO:0005938; C:cell cortex; ISO:RGD.
DR GO; GO:0008180; C:COP9 signalosome; ISO:RGD.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0042731; F:PH domain binding; ISO:RGD.
DR GO; GO:0030507; F:spectrin binding; ISO:RGD.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0031032; P:actomyosin structure organization; IBA:GO_Central.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:1904778; P:positive regulation of protein localization to cell cortex; ISO:RGD.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF17; BAND 4.1-LIKE PROTEIN 2; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PIRSF; PIRSF002304; Membrane_skeletal_4_1; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 996 AA; 110711 MW; AE8C9954C4E18CAE CRC64;
MTTEVASASE VKKGSDPSGA DAHKEKAKEV VENEQTAASE LDEGKASQPG PTAESQSSPH
RRKRGKDPSE NRGISRFIPP WLKKQKSYSL VVAKDGGDKK EPTQADGEDQ ILDKEDTLPE
EESRAKGDAE EMAQRKHLEV KVEVREEKSA LKSSAEIQPA EQVRKDKEEE VIQDIQEEKL
EGGAAKRETK EVQTSELKAE VASQKAAKKT KTVLAKVTLL DGTEFSCDLE KRAKGQALFD
RVCEHLNLLE KDYFGLIFQE HPEQKNWLDP AKEIKRQLRS LPWLFTFNVK FYPPDPSQLT
EDITRYFLCL QLRQDISSGR LPCSFVTHAL LGSYTLQAEH GDYDPEEYDS IDLGDFQFAP
THNKELEEKV AELHKTHRGL SPAQADSQFL ENAKRLSMYG VDLHHAKDSE GVDIKLGVCA
NGLLIYKDRL RINRFAWPKI LKISYKRSNF YIKVRPGELE QFESTIGFKL PNHRAAKRLW
KVCVEHHTFY RLVSPEQPPK TKFLTLGSKF RYSGRTQAQT REASTLIDRP APQFERASSK
RVSRSLDGAP IGVVDQSLMK DFPGPPGEGS VPGPGVVSYT TVQDGRRDGK SPTKVTPLLA
EGKKNTLRVD GDNIYVRHSN LMLEDLDKAQ EAILKHQASV SELKRNFMES TPEPRPSEWE
KRRVTPLSCQ ILASSHETLN VVEEKKRAEV GKGESVITEE MNGKELSPGS GPGETRKVEP
MAHKDSTSLS SESSSSSSES EEDVGEYQPH HRVTEGTIRE EQEYEEELEE EPGQGAKVVE
REAAMPEAIP DRQAGASVLP VETEAQENVV AQKLPGEKGA HRGTAEQDMS EEAEEDQHRV
NGEVPHLDID GLPEIVCPSE PPVVKTEMVT ISDASQRTEI STKEVPIVQT ETKTITYESP
QIDGGAGGDS GVLLTAQTIT SESASTTTTT HITKTVKGGI SETRIEKRIV ITGDAALDHD
QALAQAIREA REQHPDMSVT RVVVHKETEL AEEGED
//
