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Database: UniProt
Entry: D3ZSK5
LinkDB: D3ZSK5
Original site: D3ZSK5 
ID   SETD6_RAT               Reviewed;         474 AA.
AC   D3ZSK5;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   RecName: Full=N-lysine methyltransferase SETD6;
DE            EC=2.1.1.-;
DE   AltName: Full=SET domain-containing protein 6;
GN   Name=Setd6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protein-lysine N-methyltransferase. Monomethylates 'Lys-
CC       310' of the RELA subunit of NF-kappa-B complex, leading to down-
CC       regulate NF-kappa-B transcription factor activity. Monomethylates
CC       'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the
CC       maintenance of embryonic stem cell self-renewal (By similarity).
CC       {ECO:0000250|UniProtKB:Q8TBK2, ECO:0000250|UniProtKB:Q9CWY3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TBK2}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SETD6 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
DR   EMBL; CH474006; EDL87271.1; -; Genomic_DNA.
DR   RefSeq; NP_001099637.1; NM_001106167.1.
DR   UniGene; Rn.18307; -.
DR   SMR; D3ZSK5; -.
DR   STRING; 10116.ENSRNOP00000016626; -.
DR   PaxDb; D3ZSK5; -.
DR   PeptideAtlas; D3ZSK5; -.
DR   PRIDE; D3ZSK5; -.
DR   Ensembl; ENSRNOT00000016626; ENSRNOP00000016626; ENSRNOG00000012447.
DR   GeneID; 291844; -.
DR   KEGG; rno:291844; -.
DR   UCSC; RGD:1560538; rat.
DR   CTD; 79918; -.
DR   RGD; 1560538; Setd6.
DR   eggNOG; KOG1338; Eukaryota.
DR   eggNOG; ENOG410ZN0H; LUCA.
DR   GeneTree; ENSGT00940000153577; -.
DR   InParanoid; D3ZSK5; -.
DR   KO; K05302; -.
DR   OMA; TCSIGGL; -.
DR   OrthoDB; 490654at2759; -.
DR   PhylomeDB; D3ZSK5; -.
DR   TreeFam; TF106399; -.
DR   Reactome; R-RNO-3214841; PKMTs methylate histone lysines.
DR   PRO; PR:D3ZSK5; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Bgee; ENSRNOG00000012447; Expressed in 10 organ(s), highest expression level in liver.
DR   Genevisible; D3ZSK5; RN.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051059; F:NF-kappaB binding; IBA:GO_Central.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0034968; P:histone lysine methylation; ISS:UniProtKB.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR   GO; GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
DR   GO; GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
DR   GO; GO:0019827; P:stem cell population maintenance; ISS:UniProtKB.
DR   Gene3D; 3.90.1420.10; -; 1.
DR   InterPro; IPR011383; N-lys_methylase_SETD6.
DR   InterPro; IPR015353; Rubisco_LSMT_subst-bd.
DR   InterPro; IPR036464; Rubisco_LSMT_subst-bd_sf.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF09273; Rubis-subs-bind; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF011771; RMS1_SET; 1.
DR   SUPFAM; SSF81822; SSF81822; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Methyltransferase; Nucleus; Phosphoprotein;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    474       N-lysine methyltransferase SETD6.
FT                                /FTId=PRO_0000405841.
FT   DOMAIN       63    287       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   MOD_RES      14     14       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:Q9CWY3}.
SQ   SEQUENCE   474 AA;  53362 MW;  1673696BC0D7EF40 CRC64;
     MAAPAKRARV SDASPLAAPC PVPRAAARVP LPLPAGPSGH EPESDAVAGF LRWCTRVGLE
     LSPKVLVSRQ GTVAGYGMVA RESVQPGELL FAVPRSALLS PHTCSISDLL ERERGALQSL
     SGWVPLLLAL LHELQAPASP WSPYFALWPE LGRLEHPMFW PEEERLRLLK GTGVPEAVEK
     DLVNIRSEYY SIVLPFMEAH SDLFSPTVRS LELYRQLVAL VMAYSFQEPL EEEEDEKEPN
     SPLMVPAADI LNHIANHNAN LEYSAEYLRM VATQPILKGH EIFNTYGQMA NWQLIHMYGF
     AEPYPNNTDD TADIQMVAVR EAALQGTEDE TERLLLCERW DFLCKQELVG EEGAFVIGRE
     EVLTEEELAT TLKVLCMPAE EFRDYKERAG WGEEETEDGS LAITNIPKLQ ESWKRLLRDS
     VLLTLQTYAT DLKTEQDLLS NKEVYAKLSW REQQALQVRY GQKMILHRLL ELTS
//
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