GenomeNet

Database: UniProt
Entry: D3ZW56_RAT
LinkDB: D3ZW56_RAT
Original site: D3ZW56_RAT 
ID   D3ZW56_RAT              Unreviewed;      1157 AA.
AC   D3ZW56;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 3.
DT   05-JUN-2019, entry version 63.
DE   SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSRNOP00000044067};
GN   Name=Nfasc {ECO:0000313|Ensembl:ENSRNOP00000044067,
GN   ECO:0000313|RGD:620911};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000044067, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000044067, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044067,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|Ensembl:ENSRNOP00000044067}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000044067};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [4] {ECO:0000213|PubMed:24090084}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24090084;
RA   Parker B.L., Thaysen-Andersen M., Solis N., Scott N.E., Larsen M.R.,
RA   Graham M.E., Packer N.H., Cordwell S.J.;
RT   "Site-specific glycan-peptide analysis for determination of N-
RT   glycoproteome heterogeneity.";
RL   J. Proteome Res. 12:5791-5800(2013).
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DR   EMBL; AABR07072325; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105703; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC134289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001153787.1; NM_001160315.1.
DR   SMR; D3ZW56; -.
DR   PRIDE; D3ZW56; -.
DR   Ensembl; ENSRNOT00000044972; ENSRNOP00000044067; ENSRNOG00000030515.
DR   GeneID; 116690; -.
DR   CTD; 23114; -.
DR   RGD; 620911; Nfasc.
DR   GeneTree; ENSGT00940000157024; -.
DR   OrthoDB; 434404at2759; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000030515; Expressed in 8 organ(s), highest expression level in brain.
DR   ExpressionAtlas; D3ZW56; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   GO; GO:0042552; P:myelination; IEA:InterPro.
DR   GO; GO:0007422; P:peripheral nervous system development; IEA:InterPro.
DR   GO; GO:0050808; P:synapse organization; IEA:InterPro.
DR   GO; GO:0019226; P:transmission of nerve impulse; IEA:InterPro.
DR   CDD; cd00063; FN3; 4.
DR   Gene3D; 2.60.40.10; -; 10.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013151; Immunoglobulin.
DR   InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR   InterPro; IPR026965; NFASC.
DR   PANTHER; PTHR44170:SF12; PTHR44170:SF12; 2.
DR   Pfam; PF13882; Bravo_FIGEY; 1.
DR   Pfam; PF00041; fn3; 4.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF00047; ig; 1.
DR   SMART; SM00060; FN3; 4.
DR   SMART; SM00409; IG; 6.
DR   SMART; SM00408; IGc2; 6.
DR   SUPFAM; SSF48726; SSF48726; 6.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   PROSITE; PS50853; FN3; 4.
DR   PROSITE; PS50835; IG_LIKE; 6.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25   1157       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003053035.
FT   TRANSMEM   1027   1048       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       35    131       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      137    224       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      238    326       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      331    418       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      423    511       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      515    597       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      609    704       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      706    802       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      807    909       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      913   1008       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   REGION      689    719       Disordered. {ECO:0000256|MobiDB-lite:
FT                                D3ZW56}.
FT   REGION      894    913       Disordered. {ECO:0000256|MobiDB-lite:
FT                                D3ZW56}.
FT   REGION      990   1013       Disordered. {ECO:0000256|MobiDB-lite:
FT                                D3ZW56}.
FT   REGION     1058   1157       Disordered. {ECO:0000256|MobiDB-lite:
FT                                D3ZW56}.
FT   COMPBIAS    689    708       Polar. {ECO:0000256|MobiDB-lite:D3ZW56}.
FT   COMPBIAS   1058   1082       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                D3ZW56}.
FT   COMPBIAS   1084   1105       Polar. {ECO:0000256|MobiDB-lite:D3ZW56}.
FT   COMPBIAS   1128   1142       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                D3ZW56}.
FT   COMPBIAS   1143   1157       Polar. {ECO:0000256|MobiDB-lite:D3ZW56}.
SQ   SEQUENCE   1157 AA;  130260 MW;  07D1CD9881BE28AB CRC64;
     MARQQAPPWV HVALILFLLS LGGAIEIPMD LTQPPTITKQ SVKDHIVDPR DNILIECEAK
     GNPAPSFHWT RNSRFFNIAK DPRVSMRRRS GTLVIDFRSG GRPEEYEGEY QCFARNKFGT
     ALSNRIRLQV SKSPLWPKEN LDPVVVQEGA PLTLQCNPPP GLPSPVIFWM SSSMEPITQD
     KRVSQGHNGD LYFSNVMLQD MQTDYSCNAR FHFTHTIQQK NPFTLKVLTT RGVAERTPSF
     MYPQGTSSSQ MVLRGMDLLL ECIASGVPTP DIAWYKKGGD LPSDKAKFEN FNKALRITNV
     SEEDSGEYFC LASNKMGSIR HTISVRVKAA PYWLDEPKNL ILAPGEDGRL VCRANGNPKP
     TVQWLVNGDP LQSAPPNPNR EVAGDTIIFR DTQISSRAVY QCNTSNEHGY LLANAFVSVL
     DVPPRMLSPR NQLIRVILYN RTRLDCPFFG SPIPTLRWFK NGQGSNLDGG NYHVYENGSL
     EIKMIRKEDQ GIYTCVATNI LGKAENQVRL EVKDPTRIYR MPEDQVAKRG TTVQLECRVK
     HDPSLKLTVS WLKDDEPLYI GNRMKKEDDS LTIFGVAERD QGSYTCMAST ELDQDLAKAY
     LTVLGRPDRP RDLELTDLAE RSVRLTWIPG DDNNSPITDY VVQFEEDQFQ PGVWHDHSKF
     PGSVNSAVLH LSPYVNYQFR VIAVNEVGSS HPSLPSERYR TSGAPPESNP SDVKGEGTRK
     NNMEITWTPM NATSAFGPNL RYIVKWRRRE TRETWNNVTV WGSRYVVGQT PVYVPYEIRV
     QAENDFGKGP EPETVIGYSG EDYPRAAPTE VKIRVLNSTA ISLQWNRVYS DTVQGQLREY
     RAYYWRESSL LKNLWVSQKR QQASFPGDRP RGVVGRLFPY SNYKLEMVVV NGRGDGPRSE
     TKEFTTPEGV PSAPRRFRVR QPNLETINLE WDHPEHPNGI LIGYTLRYVP FNGTKLGKQM
     VENFSPNQTK FSVQRADPVS RYRFSLSART QVGSGEAATE ESPTPPNEAT PTAAYTNNQT
     DIATQGWFIG LMCAIALLVL ILLIVCFIKR SRGGKYPVRE KKDVPLGPED PKEEDGSFDY
     SDEDNKPLQG SQTSLDGTIK QQESDDSLVD YGEGGEGQFN EDGSFIGQYT VRKDKEETEG
     NESSEATSPV NAIYSLA
//
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