ID D3ZXT8_RAT Unreviewed; 902 AA.
AC D3ZXT8;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Transforming growth factor, beta receptor associated protein 1 {ECO:0000313|Ensembl:ENSRNOP00000056202.4};
GN Name=Tgfbrap1 {ECO:0000313|Ensembl:ENSRNOP00000056202.4,
GN ECO:0000313|RGD:1310772};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000056202.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000056202.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000056202.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000056202.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000056202.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006244850.1; XM_006244788.3.
DR AlphaFoldDB; D3ZXT8; -.
DR PaxDb; 10116-ENSRNOP00000056202; -.
DR PeptideAtlas; D3ZXT8; -.
DR Ensembl; ENSRNOT00000037094.7; ENSRNOP00000056202.4; ENSRNOG00000024562.7.
DR UCSC; RGD:1310772; rat.
DR AGR; RGD:1310772; -.
DR CTD; 9392; -.
DR RGD; 1310772; Tgfbrap1.
DR VEuPathDB; HostDB:ENSRNOG00000024562; -.
DR eggNOG; KOG2063; Eukaryota.
DR GeneTree; ENSGT00530000063596; -.
DR HOGENOM; CLU_004190_3_0_1; -.
DR OMA; VLKEIQC; -.
DR OrthoDB; 198927at2759; -.
DR TreeFam; TF328650; -.
DR PRO; PR:D3ZXT8; -.
DR Proteomes; UP000002494; Chromosome 9.
DR Bgee; ENSRNOG00000024562; Expressed in adult mammalian kidney and 18 other cell types or tissues.
DR ExpressionAtlas; D3ZXT8; baseline and differential.
DR GO; GO:0033263; C:CORVET complex; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005769; C:early endosome; ISO:RGD.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0046332; F:SMAD binding; ISO:RGD.
DR GO; GO:0005160; F:transforming growth factor beta receptor binding; ISO:RGD.
DR GO; GO:0006914; P:autophagy; IBA:GO_Central.
DR GO; GO:0034058; P:endosomal vesicle fusion; ISO:RGD.
DR GO; GO:0008333; P:endosome to lysosome transport; ISO:RGD.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; ISO:RGD.
DR GO; GO:0007165; P:signal transduction; ISO:RGD.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR032914; Vam6/VPS39/TRAP1.
DR InterPro; IPR019452; VPS39/TGF_beta_rcpt-assoc_1.
DR InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR PANTHER; PTHR12894; CNH DOMAIN CONTAINING; 1.
DR PANTHER; PTHR12894:SF27; TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF10366; Vps39_1; 1.
DR Pfam; PF10367; Vps39_2; 1.
DR PROSITE; PS50236; CHCR; 1.
DR PROSITE; PS50219; CNH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 902 AA; 101924 MW; 3D3ECC7E6ACE7E54 CRC64;
MSGNVVPSPC STTCLCGFLD PPFKLRLQTL HLQKVVTDYA VDMMNIKAFT LVSAVERELL
MGDRDHISIE CVECCGRNLY VGTNDCFIYH FLLEEKAMPT GTATFIATKQ LHRHLGFKKP
VNELCAASAL NRLLVLCDNS ITLVNMLNLE PVPSGARIKG ATTFAVNENP VNGDPFCVEV
CIISVKRRTV QMFLVYEDRV QIVKEVSTTE QPLAVAVDGY FLCLALTTQY IILNYSTGFS
QDLFPYCSEE KPPIVKRIGR QEFLLAGPGG LGMFATVAGI SQRAPVHWSE NVIGAAVCFP
YVIALDDEFI TVHSMLDQQQ KQTLPFKEGH ILQDFEGRVI VATSKGVYIL VPLPLEKQIQ
DLLANRRVEE ALVLAKGARR NIPKEKFQVM YRRILQQAGF IQFAQLQFLE AKELFRSSQL
DVRELISLYP FLLPTSSSFT RSHPPLHEYA DLNQLTQGDQ EKMAKCKRFL MSYLNEIRST
EVANGYKEDI DTALLKLYAE ADHDSLLDLL VTENSCLLTD SAAWLEKHKK YFALGLLYHY
NKQDASAVQL WVNIVNGDIQ DSTRSDLYEY IVDFLTYCLD QELVWTHADW LLQKSQEVGV
QVFTKRPLDE QQQTSFNPDD IISCLKKYPK ALVKYLEHLV IDRRLQKEEY HTHLALLYLE
EVLRQRAPTG GKDVEATETQ AKLRRLLQKS DLYRVHLLKE KIQGAGLPME SAILHGKLGE
HEKALHILVH EMGDFSAAED YCLWSSEGQD AACRQRLFHT LLAMYLRAGP SAHDLTVAAV
DLLNHHAREF DATQVLQLLP DTWSVQLLCP FLTGAMRDSI HARRTTQVAL GLAKSENLIY
MYDKMKLKGS AIWLSEKKLC QLCQNPFGEP VFVRYPNGGL VHTHCAASRH TNPSSPSPGT
RT
//
