ID D3ZZB0_RAT Unreviewed; 1612 AA.
AC D3ZZB0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Disco-interacting protein 2 homolog C {ECO:0000313|Ensembl:ENSRNOP00000020634.6};
GN Name=Dip2c {ECO:0000313|Ensembl:ENSRNOP00000020634.6,
GN ECO:0000313|RGD:1560155};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000020634.6, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000020634.6, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000020634.6,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000020634.6}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000020634.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DIP2 family.
CC {ECO:0000256|ARBA:ARBA00007735}.
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DR RefSeq; NP_001100830.1; NM_001107360.1.
DR AlphaFoldDB; D3ZZB0; -.
DR STRING; 10116.ENSRNOP00000020634; -.
DR PhosphoSitePlus; D3ZZB0; -.
DR jPOST; D3ZZB0; -.
DR PaxDb; 10116-ENSRNOP00000020634; -.
DR Ensembl; ENSRNOT00000020634.7; ENSRNOP00000020634.6; ENSRNOG00000015288.8.
DR GeneID; 307067; -.
DR KEGG; rno:307067; -.
DR AGR; RGD:1560155; -.
DR CTD; 22982; -.
DR RGD; 1560155; Dip2c.
DR VEuPathDB; HostDB:ENSRNOG00000015288; -.
DR eggNOG; KOG3628; Eukaryota.
DR GeneTree; ENSGT00950000182997; -.
DR HOGENOM; CLU_001345_0_0_1; -.
DR OMA; LVWTYWT; -.
DR TreeFam; TF312871; -.
DR Proteomes; UP000002494; Chromosome 17.
DR Bgee; ENSRNOG00000015288; Expressed in heart and 18 other cell types or tissues.
DR CDD; cd05905; Dip2; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR037337; Dip2-like_dom.
DR InterPro; IPR010506; DMAP1-bd.
DR PANTHER; PTHR22754; DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED; 1.
DR PANTHER; PTHR22754:SF33; DISCO-INTERACTING PROTEIN 2 HOMOLOG C; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF06464; DMAP_binding; 1.
DR SMART; SM01137; DMAP_binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR PROSITE; PS51912; DMAP1_BIND; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 1612 AA; 176889 MW; 369BEE53C0975D5B CRC64;
MADRSLEGMA LPLEVRARLA ELELELSEGD ITQKGYEKKR SKLIGAYLPQ PPTANGAAVV
RCRLQPGEGV PRRPFRSAHI GVCDIREAAA RERAASAAGN RPLFYFRFGV DQALPQERRA
PVTPSSASRY HRRRSSGSRD ERYRSDVHTE AVQAALAKHK ERKMAVPMPS KRRSLVVQTS
MDAYTPPDTS SGSEDEGSVQ GDSQGTPTSS QGSINMEHWI SQAIHGSTTS TTSSSSTQSG
GSGAAHRLAD VMAQTHIENH SAPPDVTTYT SEHSIQVERP QGSTTSRTAP KYGNAELMET
GDGVPVSSRV SAKIQQLVNT LKRPKRPPLR EFFVDDFEEL LEVQQPDPNQ PKPEGAQMLA
TRGEQLGVVT NWPPSLEAAL QRWGTISPKA PCLTTMDTNG KPLYILTYGK LWTRSMKVAY
NILHKLGTKQ EPMVRPGDRV ALVFPNNDPA AFMVAFYGCL LAEVVPVPIE VPLTRKDAGS
QQIGFLLGSC GVTVALTSDA CHKGLPKSPT GEIPQFKGWP KLLWFVTESK HLSKPPRDWF
PHIKDANNDT AYIEYKTCKD GSVLGVTVTR IALLTHCQAL TQACGYTEAE TIVNVLDFKK
DVGLWHGILT SVMNMMHVIS IPYALMKVNP LSWIQKVCQY KAKVACVKSR DMHWALVAHR
DQRDVNLSSL RMLIVADGAN PWSISSCDAF LNVFQSKGLR QEVICPCASS PEALTVAIRR
PTDDSNQPPG RGVLSMHGLT YGVIRVDSEE KLSVLTVQDV GLVMPGAIMC SVKPDGVPQL
CRTDEIGELC VCAVATGTSY YGLSGMTKNT FEVFPMTSSG APISEYPFIR TGLLGFVGPG
GLVFVVGKMD GLMVVSGRRH NADDIVATAL AVEPMKFVYR GRIAVFSVTV LHDERIVIVA
EQRPDSTEED SFQWMSRVLQ AIDSIHQVGV YCLALVPANT LPKTPLGGIH LSETKQLFLE
GSLHPCNVLM CPHTCVTNLP KPRQKQPEIG PASVMVGNLV SGKRIAQASG RDLGQIEDND
QARKFLFLSE VLQWRAQTTP DHLLYTLLNC RGTIANSLTC VQLHKRAEKI AVMLMERGHL
QDGDHVALVY PPGIDLIAAF YGCLYAGCVP ITVRPPHPQN IATTLPTVKM IVEVSRSACL
MTTQLICKLL RSREAAAAVD VRTWPLILDT DDLPKKRPAQ IYKPSNPDTL AYLDFSVSTT
GMLAGVKMSH AATSAFCRSI KLQCELYPSR EVAICLDPYC GLGFVLWCLC SVYSGHQSIL
IPPSELETNP ALWLLAVSQY KVRDTFCSYS VMELCTKGLG SQTESLKARG LDLSRVRTCV
VVAEERPRIA LTQSFSKLFK DLGLHPRAVS TSFGCRVNLA ICLQGTSGPD PTTVYVDMRA
LRHDRVRLVE RGSPHSLPLM ESGKILPGVR IIIANPETKG PLGDSHLGEI WVHSAHNASG
YFTIYGDESL QSDHFNSRLS FGDTQTIWAR TGYLGFLRRT ELTDANGERH DALYVVGALD
EAMELRGMRY HPIDIETSVI RAHKSVTECA VFTWTNLLVV VVELDGSEQE ALDLVPLVTN
VVLEEHYLIV GVVVVVDIGV IPINSRGEKQ RMHLRDGFLA DQLDPIYVAY NM
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