ID D4A6U4_RAT Unreviewed; 1417 AA.
AC D4A6U4;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 2.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Tectonin beta-propeller repeat containing 2 {ECO:0000313|Ensembl:ENSRNOP00000035369.5};
GN Name=Tecpr2 {ECO:0000313|Ensembl:ENSRNOP00000035369.5,
GN ECO:0000313|RGD:1307503};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000035369.5, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000035369.5, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000035369.5,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000035369.5}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000035369.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006225935.1; XM_006225873.3.
DR RefSeq; XP_006225937.1; XM_006225875.3.
DR RefSeq; XP_006240680.1; XM_006240618.3.
DR RefSeq; XP_008763192.1; XM_008764970.2.
DR AlphaFoldDB; D4A6U4; -.
DR SMR; D4A6U4; -.
DR STRING; 10116.ENSRNOP00000035369; -.
DR iPTMnet; D4A6U4; -.
DR PhosphoSitePlus; D4A6U4; -.
DR PaxDb; 10116-ENSRNOP00000035369; -.
DR Ensembl; ENSRNOT00000030864.7; ENSRNOP00000035369.5; ENSRNOG00000021904.7.
DR GeneID; 314456; -.
DR KEGG; rno:314456; -.
DR UCSC; RGD:1307503; rat.
DR AGR; RGD:1307503; -.
DR CTD; 9895; -.
DR RGD; 1307503; Tecpr2.
DR eggNOG; KOG3621; Eukaryota.
DR eggNOG; KOG3669; Eukaryota.
DR GeneTree; ENSGT00940000157283; -.
DR HOGENOM; CLU_005841_0_0_1; -.
DR InParanoid; D4A6U4; -.
DR OMA; WFRTGVC; -.
DR OrthoDB; 3675109at2759; -.
DR TreeFam; TF323607; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000021904; Expressed in frontal cortex and 18 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:GOC.
DR GO; GO:0032527; P:protein exit from endoplasmic reticulum; ISO:RGD.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR006624; Beta-propeller_rpt_TECPR.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR23287; RUBY-EYE2-LIKE PROTEIN; 1.
DR PANTHER; PTHR23287:SF16; TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 2; 1.
DR Pfam; PF06462; Hyd_WA; 2.
DR Pfam; PF19193; Tectonin; 1.
DR SMART; SM00706; TECPR; 10.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 1: Evidence at protein level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT REGION 400..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1395..1417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 563..577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1417 AA; 154809 MW; 5B1BC9691CE4A68A CRC64;
MASVSEPVTF REFCPLYYLL NAIPTKIQRG FRSIVVYLTA LDTNGDYIAV GSSIGMLYLY
CRHLNQMKKY NFEGKTESIT VVKLLSCFDD LVAVGTASGR VAVFQLVSSL PGRNKQLRRF
DVTGVHKTSI TALAWSPNGM KLFSGDDKGK IVYSSLDLDQ GICNSHLVLE EPSSIVQLDY
SQKVLLVSTL QRSLLFYTEE KAVKQIGSQP RKSTGKFGAC FIPGLCKQSD LTLYAARPGL
RLWKADVHGT VQATFILKDV FAGGVTPFEL YPRLEPSDGG SCSAPEKHLG LVSCFFQEGW
VLSWNEYSIY LLDTVNQATV AGLEGLGDIV SVSCTENEIF FLKGDRNIIR ISSRPEGLAS
IVRDSPEMAR CSEQVHGQHL EKSLGGTVCE ARLRGSSVAS SVASEQRSRS SSFNSTDSGS
GLLPPGSQAA PELGHSGQPS SQRFSVISSE DFDQELIVKP IKVKKRRRKR KPEGGSKSTC
HSSLESTPCS ELPADSPQSL STDLVSLASS VLSGSSVDQL STEPPDQEIS PSGELDGIIQ
DNNGPQTLHD LEVPGSTPSP VDEENSPRKE ASQCDHTQDT DLLKGVLTLP LQPGEDEGDA
DVTSELEEKP GPAADAAIHT ELCLQEQNSS AEQQEVDTME FSDPQSTFSE APLLDSSMLP
ASLSWPPGAE QWLPEIEGYE VSTEEASPEA DILTQAEVPS HLSSNPWHLL TDSQKEAPAF
ECDMGNVKGQ VTPLTSALVA NTHAHWLDQP FQDQAVTSSD EEDIYAHRLP SSSSETSVTE
LGAGRSLQDL SQPGAEETSL LKADQFAESW MGYSGPGYGI LSLAVSEKFI WCLDYKGGLF
CSALPGAGLR WQRFEDAVQQ MAVSPSGALL WKIEQKSNRA FACGKVTIKG KRHWYEALPQ
AVFVTLSDDT AWIIRTNGDL YLQTGLSVDR PCARAVKVDC PYPLSQITAR NSVVWALTEQ
RALLYREGVS SFCPEGEQWK CDIVSERQAL EPVCITLGDQ HTLWALDIHG KLWFRTGVIP
KKPQGDDDHW WQVSITDYVV FDQCSLFQTI MHATHSVATA AQAPVEKVAD KLRMAFWSQQ
LQCQPSLLGV NKSGVWISSG KNEFHVAKGS LIGTYWNNVV PRGTASATKW AFVLASPAPT
QDGSSLWLCQ SSKDLCVLSA QSAQCRPSTV QLPPDAEMRT YAACQDALWA LDSLGQVFIR
TLSKSCPTGM HWTKLDLSQL GAVRLTSLAC GNEHIWACDS KGGLYFRVGT QPLNPSLMLP
AWITIEPPVQ LAGVTLVSVH SSPNDQMLWA LDSRWNVHVR TGVTEEMPVG TDWEHVPGLQ
ACQLALSTRT VWARCPNGDL ARRYGITDKN PAGDYWKKIP GNVSCFTVTS SDELWAVGSS
GCLLQRLTKT FSHSHNTQNN QAATSHPEEL EDEWEVI
//
