ID D4A7Z1_RAT Unreviewed; 1612 AA.
AC D4A7Z1;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 2.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=RIMS binding protein 3 {ECO:0000313|Ensembl:ENSRNOP00000054476.3};
GN Name=Rimbp3 {ECO:0000313|Ensembl:ENSRNOP00000054476.3,
GN ECO:0000313|RGD:1563657};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000054476.3, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000054476.3, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000054476.3,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000054476.3}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000054476.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIMBP family.
CC {ECO:0000256|ARBA:ARBA00010749}.
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DR RefSeq; XP_001064091.1; XM_001064091.6.
DR RefSeq; XP_221302.2; XM_221302.8.
DR AlphaFoldDB; D4A7Z1; -.
DR SMR; D4A7Z1; -.
DR STRING; 10116.ENSRNOP00000054476; -.
DR PaxDb; 10116-ENSRNOP00000054476; -.
DR Ensembl; ENSRNOT00000051991.5; ENSRNOP00000054476.3; ENSRNOG00000030452.5.
DR KEGG; rno:303785; -.
DR AGR; RGD:1563657; -.
DR CTD; 85376; -.
DR RGD; 1563657; Rimbp3.
DR eggNOG; KOG3632; Eukaryota.
DR GeneTree; ENSGT00950000183203; -.
DR HOGENOM; CLU_001979_2_1_1; -.
DR InParanoid; D4A7Z1; -.
DR OMA; CQAFARQ; -.
DR OrthoDB; 5403222at2759; -.
DR TreeFam; TF316230; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000030452; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0002177; C:manchette; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0030156; F:benzodiazepine receptor binding; IBA:GO_Central.
DR GO; GO:0009566; P:fertilization; ISO:RGD.
DR GO; GO:0007286; P:spermatid development; ISO:RGD.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 3.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040325; RIMBP1/2/3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR14234; RIM BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR14234:SF21; RIMS-BINDING PROTEIN 3A-RELATED; 1.
DR Pfam; PF07653; SH3_2; 3.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00326; SH3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF50044; SH3-domain; 3.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50002; SH3; 3.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 822..889
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 982..1070
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1426..1494
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1542..1609
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1370..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..108
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 404..431
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 462..601
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 229..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1236..1251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1612 AA; 178256 MW; 2DD81DF99C3F5B29 CRC64;
MTKDSPTPLG GGRASPKKPG SPGPAAAVLE EQRRELEKLR AELEGERARG RSERRRFATQ
TRQLREAAEQ ERQQLADHLR SKWEARRLRE LRQLQEEVQR EREAEIRQLL RWKEAELRQL
QQLLHQERDV VLRQARELQR QLAQELVNRG YCSRSGASEA SAAQCRCRLQ EVLALLRWET
DGEQAARIRH LQAALDVERQ LFLKYILEHF RWQPALPGPA DPQTTHSLEE PPLEAQSNTD
GTPKPARRLG SLESLNTGVR VHSPNDLLPT RASSLESLAT AHSCSLDNTL NCPETSESEV
RAPSTTASIP DTSSPQPPPQ LPSKHRKPND LQKESSENKP CEDSTSSSPG LDYHELVRQN
SELAEALQVL VRRCCDLREE NLQLRRTGFS EEAGEKVKWL KVKHAELTDL AQRLEDRARK
LQETNLRAMS APMPGESLEG LDLGQVFTCQ RAQDLSEQAG ALQAKDLQIE ALRRECHLLQ
ARIAADLGSS SHPEEGATCA QWCNISDLDR LQRESQREVL RLQRQLTLHQ SKAGAWADTG
SPSAPSEIAR HQVQALEREL GLQRRECEEL SVQAAAAERR YEETEAQLQA ALHKGARLSE
ENARLQALAN WMKKMADENS NVSRQQSHAR QRQELEATGL LAEQLLQQEG YAQDRRQQLQ
QYQNKTPSDL RISGKEMQGL QFQPGHPSES SETTQASESQ VRDSRRLKFK TKSEEYILPL
PTRDIQPPAC LSQQENPVAL GEPAAASQVS DRNPSSQSLD SKLQAKKTSS QSNSSSEVES
MWATVPSCLS LDMDTASEVD DLEPDSMSTP LEMRSLEAPI VPKLKIFLAR YSHNPFEGPS
ERSHDELPLT AGDYVYVFGD VDEDGFYEGE LVNGQRGLVP SNLVEPISGS PILSHLFLKS
PGAGPTSLPA EHSKALKKGS LLLGEVQERG LCQAGRVDSK TDVASESLKT KTEACWLGLK
SSMEEQSFSR PLLEAKGALC LAPMELQLQN VTATSATITW ASGSNRYPHV VYLDDEEHIL
TPSGVNHYTF QGLHPGTRYQ VRVGVQLPRD LLQVLWETMS STVTFDTPLA GPPDPPLDVL
VEHHAASPGV LVVSWLPVTI DSAGSSNGVQ VTGYAVYVDG FKVTEVANAT AGNTLLELSQ
LQLPLGCQKV SVRTMSLYGE SLDSVPAQIP EDCFSCYPFL EAPPFNYTDG DPFPVCHQKL
AQASLSAKSS PHVPGSCGEP QAKFLEAFSE EQPRKHLSLS SLSSDGANKQ VQGPTEAWKG
YEKDLSFQRS PQNHKPPLLF GQSGVEEGHA PHICISGSPS PGFIHLSSEV GPGKILCWEE
PGLEKALLQN QYAQMVPHHQ QGSSQCHTAD FHHIFEEKEA LCLDSRCTEK PEQRKKSQNG
QRQGTPGSKR ECQFHEPTSV LCPAPTSKII KIASGGSDQL ETDGNSPVRV FLALFDHSPL
ARSVNSEATE EELSFQKGQL LRVWGSRDHH GFYHGECNGQ VGKIPGHLVV EVEVGTQQTD
GRWLLPPQGH LHSEAQREDL EGLTNSQGSY MLQGNSRTPT LWTPKTMVAA LDYDPRDGRA
GVRAKGKLVL RAGDVVTVYG PVDDKGFYYG EYGGHRGLVP AHLLDDLPVH GE
//