ID D4A899_RAT Unreviewed; 2334 AA.
AC D4A899;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Vacuolar protein sorting 13 homolog A {ECO:0000313|Ensembl:ENSRNOP00000014800.7};
GN Name=Vps13a {ECO:0000313|Ensembl:ENSRNOP00000014800.7,
GN ECO:0000313|RGD:1311340};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000014800.7, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000014800.7, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000014800.7,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000014800.7}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000014800.7};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR AlphaFoldDB; D4A899; -.
DR STRING; 10116.ENSRNOP00000014800; -.
DR PaxDb; 10116-ENSRNOP00000014800; -.
DR PeptideAtlas; D4A899; -.
DR Ensembl; ENSRNOT00000014800.8; ENSRNOP00000014800.7; ENSRNOG00000025539.7.
DR AGR; RGD:1311340; -.
DR RGD; 1311340; Vps13a.
DR VEuPathDB; HostDB:ENSRNOG00000025539; -.
DR eggNOG; KOG1809; Eukaryota.
DR GeneTree; ENSGT00950000183083; -.
DR HOGENOM; CLU_000135_1_1_1; -.
DR InParanoid; D4A899; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000025539; Expressed in quadriceps femoris and 18 other cell types or tissues.
DR GO; GO:0031045; C:dense core granule; ISO:RGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:RGD.
DR GO; GO:0010008; C:endosome membrane; ISO:RGD.
DR GO; GO:0019898; C:extrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0005811; C:lipid droplet; ISO:RGD.
DR GO; GO:0005765; C:lysosomal membrane; ISO:RGD.
DR GO; GO:0044233; C:mitochondria-associated endoplasmic reticulum membrane; ISO:RGD.
DR GO; GO:0031966; C:mitochondrial membrane; ISO:RGD.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISO:RGD.
DR GO; GO:0099013; C:neuronal dense core vesicle lumen; ISO:RGD.
DR GO; GO:0097225; C:sperm midpiece; ISO:RGD.
DR GO; GO:0006914; P:autophagy; ISO:RGD.
DR GO; GO:0030317; P:flagellated sperm motility; ISO:RGD.
DR GO; GO:0007626; P:locomotory behavior; ISO:RGD.
DR GO; GO:1905146; P:lysosomal protein catabolic process; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0045053; P:protein retention in Golgi apparatus; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0035176; P:social behavior; ISO:RGD.
DR GO; GO:0030382; P:sperm mitochondrion organization; ISO:RGD.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF22; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13A; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 2.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:D4A899};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 3..36
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 56..112
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 135..367
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 563..787
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1137..1236
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1930..2330
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT COILED 97..124
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2334 AA; 266119 MW; C5D9EA0F3522BD53 CRC64;
MVFESVVVDV LNRFLGDYVV NLDQSQLSLG IWKGNGVAAP GSRETAAWFL VASVLGQPGS
LQLKIPWKNL YTQPVEAVLE EIYLLIVPSS RIQYDPIKEE KQLMEAKQQE LKRIEEAKQK
VVDQENPREE KQDTFAEKLV TQIIKNLQVQ ISSIHVRYED DITNREKPLS FGISLQNLSL
QTTDQYWIPC LHDDTEKLVR KLIRLDNLFA YWNVNSEMFY LNDYDDALEA LKNGIVNENI
IPEGYDFVFR PISANAKLQM NRRSDFDFSD PKINLDIELH TIVIEFNKPQ YFSLMELLES
IDMMTQNLPY RKFKPSVPLH LHAEEWWAYA IHGILEVNVC PSLRMWSWEH IKNHRYKMKQ
YREFYKKKLT NKKPSPEILM SLEELEKTLD VFNITIARQQ AEVEVKKAGY KIYKEGLKDP
EDNAGWFSWM WSWSESNANQ QQDVKPGILA EMLTPEEKAL LYEAIGYSET AVDPTLPKTF
EALKFFVHLK SMSIVLRENR QKPELLNVVV EGLSTSIVQR PGAQALKFET KIDSFHITGL
PDDFKKPHLL SSLDDMSLFR ITFEINPLDE TVSQRCTIEA EPLEMIYDAR TVNSIVEFFR
PPKDVRLAQL TTATLTKLEE FREKTATGLL YIIETQKVLD LRINVKASYV IVPQYGNFSP
TSNLLLLDLG HLKVTSKRRS GLPDVKPSGA SLEDIMHRAY DSFDIQLSSI QLLYSRVGDN
WKEARKLNVS TQHILIPMHV NIELSKAMVF MDIKMPKFKI FGKLPLVSLR ISDKKLQGIM
ELLESIPKPE PVTDVSAPAR SFQIQASTMP VSHISQKLIP LLEQSATEDD SEEEFFDAPC
SPLEEYPQVS CRVESTRRKK LQKKDGSMNF IQLSMRFEVA EVLIQFYHLV GDCELPVLEM
GVLGLGTEVE IRKFDLKGNA FLKELWLKCP GYLDEHKKPV YLITTLDNTM EDLLTLEFMR
VEKNAPNLNS TYNNVLQLIK VNFSSLDIHL HTEALLNTMN YLNNILPELG ETSASVSAAE
PEDKGDIIKK LALKLPTNED IITLQLLAEL SCLRIFIQDQ KQNISEIKIE GLDSEMIMKP
LVTEINAKLR NIIVLDSDKM AVYKKAVYIT GKEVFSFKMI SYMDATAGYA YTDMSVVDAR
VYLTVGCIEV VFVTKFLYSI LAFINNFQAV KNALAEATVQ AAGMAADGVK ELARKSSRFA
LDVNIKAPVV LIPQSPVSRN VFVADFGLIT IKNIFVTVTE TQSNIPPVID LITIKLSKMR
LYRSQFMNNT YQEVLDLLLP LNLEVIVERN LSWEWYKEVP CFNIKAQLKP MEFILSQEDL
TTVFQTLYGN IWYGRDVPAP SSVNKGPEIM TTEVTSTSYH SGATMVTSAV VEVHPQASPA
NTTLNVSFQT DHLIMTLYSP GPDQASFTDV RDPSLELAEF KLENIISDLK VYTDDSMVFS
FSLKNCILDD KRPHVMKATP RMIGLTVGFD KKDMVDVKYR QIRDVFVTDV VVQEMYVCAS
VEFLMTVARV FFDAYMTSTA LETSVQTWTT REAPVQELRK WEMNILIKNP EIVFVADMTR
NDAPALVITT QCEICCKGEP ESNTVTAAIK DFQVRACPFL PVKRKGRVTT VLQPCDLFYQ
ATQFGTDPQT IDISVKSLTL KVSPVIINTI ITVTSALYTT KETVPEESTS NVAHLWDKKD
TKNLKMWFLE ESNETEKVVP TDEVMPGGET LNLNIDSIFI VLEAGIGHRT VPMLLAKSSF
LGESKNWRTL INLHCQLELE VHYFNEMFGV WEPLLEPLEI DQSDDFRPWN LGIKMKKKAK
EAIVESDSEE ENYKVPEYKT AISFFSRDQL NITLSKCGLV MLSNLVEAFT EAATGSSAVF
LRDLAPFMIL NSLGLTVSVS PSDSFHVLNV PLAKSYELKN EESLSMDYVR TKDNDHFNAM
TSLSSKLFFI LLTPANHSVA DKIPLTKVGR RLYTVRHRES GVERSIICQI DTVEGSKKVT
IRSPVQIKNH FSIPISVFEG DTLLGIASPE NEFNIPLASY RSSLSLKPED EDYQLCEGID
FEEIIKHDGQ LLKKKCRSIS PSKKSFVINI VPEKDNLASL SAYSEDGWDL PYVMHLWPPI
LIRNLLPYKI AYYLEGIENT VCTLSEGHSS QIYNVEMDQA KLHLKLLDYL NHDWKSEFQI
DPNQQDINFI NFTCLTEMEK SDLDIAIHMT YNTGQTVVAF HSPYWMVNKT NRMLQYKADG
IHRKHPPNYK KPVLFSFQPN HFFNNNKVQL MVTDSELSDQ FSIDTVGSHG AIKCKGLKME
YQVGVTIDLS SFNITRIVTF IPFYMIKNKS RYHISVTEEG SDKWLSLDLE QVRN
//
