ID D4A8C4_RAT Unreviewed; 1016 AA.
AC D4A8C4;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 3.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Zinc finger protein 316 {ECO:0000313|Ensembl:ENSRNOP00000045973.4};
GN Name=Zfp316 {ECO:0000313|Ensembl:ENSRNOP00000045973.4,
GN ECO:0000313|RGD:1311647};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000045973.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000045973.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000045973.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000045973.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000045973.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; NP_001100591.1; NM_001107121.1.
DR RefSeq; XP_008767185.1; XM_008768963.2.
DR RefSeq; XP_008767186.1; XM_008768964.2.
DR RefSeq; XP_008767187.1; XM_008768965.2.
DR RefSeq; XP_008767188.1; XM_008768966.2.
DR RefSeq; XP_008767189.1; XM_008768967.2.
DR RefSeq; XP_017453807.1; XM_017598318.1.
DR AlphaFoldDB; D4A8C4; -.
DR SMR; D4A8C4; -.
DR STRING; 10116.ENSRNOP00000045973; -.
DR PaxDb; 10116-ENSRNOP00000045973; -.
DR Ensembl; ENSRNOT00000052327.5; ENSRNOP00000045973.4; ENSRNOG00000001094.8.
DR GeneID; 304293; -.
DR KEGG; rno:304293; -.
DR AGR; RGD:1311647; -.
DR CTD; 54201; -.
DR RGD; 1311647; Zfp316.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162728; -.
DR HOGENOM; CLU_002678_23_2_1; -.
DR OMA; EEETPWI; -.
DR OrthoDB; 4630933at2759; -.
DR TreeFam; TF350850; -.
DR Proteomes; UP000002494; Chromosome 12.
DR Bgee; ENSRNOG00000001094; Expressed in frontal cortex and 18 other cell types or tissues.
DR Genevisible; D4A8C4; RN.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 15.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24408:SF58; LINKING IMMUNITY AND METABOLISM-RELATED; 1.
DR PANTHER; PTHR24408; ZINC FINGER PROTEIN; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 14.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 8.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023015};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 1016 AA; 110731 MW; 83A40C6D44C50797 CRC64;
MMAALHTAPD SPDTQLEPAE DGSECDAEPE EEEEEEEEDD EQGREEEEVV VEEEVATQVQ
EAAGVEVEAN SADTGGGDDG DDGDVEEVLA EEQTLSLGTQ KRLSNGADAK SPALQGKALQ
ASRLPPTTQG DDPEEEEEEE DDEHFLTQGL VTFEDVAVYF SLEEWERLDV DQRDLYRDVM
QENYGILVSL GYPIPKPDLI FHLEQGEEPW VEDSPHPEEG DVVTGVYTGA WFWNDDLEDH
EEEDDEDFLA EMAEEENEPP GLWSAAYGVG DVPGTWGPDD SDSVQTPEGW GPNPGSLGIL
AEEVEAKHFL SGRGPGENFL VPWAFPAVAV PIGCPETTCD VCGKVFPHRS RLAKHQRYHA
AVKPFGCEEC GKGFVYRSHL AIHQRTHTGE KPFPCPDCGK RFVYKSHLVT HRRIHTGERP
YRCVFCGAGF GRRSYLVTHQ RTHTGERPYP CLHCGRSFSQ SSALARHQAV HTADRPHCCP
DCGQAFRLRA DFQRHRRGGG CTEPSSGDGA LTAPHEVGMA PNEVEMAIAA VATAEPEELE
SGLAEKNEEP KAGVADGDNE VEVRQDEQVV VAAAAEATVP DSKKDPEPDR RFREMGNGLA
EGEGPSSHRF GFHFPMHPKS WLHPDGFPLL GFPEFSERLQ TDGRHLPGPL GAPLSLQGMG
LACDPFRSAG PGARADSGLR AFAPAVGSLL SEPAPAALAE EESPWICSDC GKTFGRRAAL
AKHQRYHAGE RPHRCADCGK SFVYGSHLAR HRRTHTGERP FPCPECGARF ARGSHLAAHV
RGHTGEKPFV CGVCGAGFSR RAHLTAHGRA HTGERPYACA ECGRRFGQSA ALTRHQWAHA
EEKPHRCPDC GKGFGHSSDF KRHRRTHTGE KPFRCADCGR GFAQRSNLAK HRRGHTGERP
FPCPECGKRF SQRSVLVTHQ RTHTGERPYL CSNCGRRFSQ SSHLLTHMKT HRGQGGAPAQ
NTSAKAQAPA KAIPPLPPSG SGSGAGTLLE FAGGTSFGSD PAAFASPSGT YEESIL
//
