ID D4A9P0_RAT Unreviewed; 1341 AA.
AC D4A9P0;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 104.
DE SubName: Full=Kinesin family member 7 {ECO:0000313|Ensembl:ENSRNOP00000038247.4};
GN Name=Kif7 {ECO:0000313|Ensembl:ENSRNOP00000038247.4,
GN ECO:0000313|RGD:1310310};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000038247.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000038247.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000038247.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000038247.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000038247.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR RefSeq; XP_001065361.2; XM_001065361.6.
DR RefSeq; XP_218828.5; XM_218828.9.
DR AlphaFoldDB; D4A9P0; -.
DR SMR; D4A9P0; -.
DR STRING; 10116.ENSRNOP00000038247; -.
DR iPTMnet; D4A9P0; -.
DR PhosphoSitePlus; D4A9P0; -.
DR jPOST; D4A9P0; -.
DR PaxDb; 10116-ENSRNOP00000038247; -.
DR PeptideAtlas; D4A9P0; -.
DR Ensembl; ENSRNOT00000033491.5; ENSRNOP00000038247.4; ENSRNOG00000026857.5.
DR GeneID; 293047; -.
DR UCSC; RGD:1310310; rat.
DR AGR; RGD:1310310; -.
DR CTD; 374654; -.
DR RGD; 1310310; Kif7.
DR eggNOG; KOG0244; Eukaryota.
DR GeneTree; ENSGT00940000159749; -.
DR HOGENOM; CLU_005591_0_0_1; -.
DR InParanoid; D4A9P0; -.
DR OMA; WLYPLTE; -.
DR OrthoDB; 5395177at2759; -.
DR PhylomeDB; D4A9P0; -.
DR TreeFam; TF325946; -.
DR Reactome; R-RNO-5610787; Hedgehog 'off' state.
DR Reactome; R-RNO-5632684; Hedgehog 'on' state.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000026857; Expressed in thymus and 18 other cell types or tissues.
DR Genevisible; D4A9P0; RN.
DR GO; GO:0097542; C:ciliary tip; ISO:RGD.
DR GO; GO:0005929; C:cilium; ISO:RGD.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; ISO:RGD.
DR GO; GO:0035904; P:aorta development; ISO:RGD.
DR GO; GO:0003279; P:cardiac septum development; ISO:RGD.
DR GO; GO:0060976; P:coronary vasculature development; ISO:RGD.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR CDD; cd01372; KISc_KIF4; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47969; CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED; 1.
DR PANTHER; PTHR47969:SF8; KINESIN FAMILY MEMBER 7; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 15..349
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 361..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1280..1341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 489..537
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 701..756
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 781..937
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 962..1025
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1174..1208
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 94..101
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1341 AA; 150578 MW; 1EC298BF441A64E7 CRC64;
MGLEAQKLSG AEEAPVRVAL RVRPLLPKEL LHGHQSCLQV EPERGRITLG RDRHFGFHVV
LGEDAGQEAV YQACVQPLLE AFFEGFNATV FAYGQTGSGK TYTMGEASVA SLHEDEQGII
PRAMAEAFKL IDENDLLDCL VHVSYLELYK EEFRDLLEVG TASRDIQLRE DDRGNVVLCG
VKEVDVEGLD EVLSLLEMGN AARHTGATHF NRLSSRSHTV FTVTLEQRGR APTRLPRPGA
GHLLVSKFHF VDLAGSERVL KTGSTGERLK ESIQINSTLL ALGNVISALG DPQRRGSHIP
YRDSKITRIL KDSLGGNAKT VMIACVSPSS SDFDETLNTL NYASRAQNIR NRATVNWRPE
AERVPEEQAA GARGPPRHRS ETRIIHRGRR VLCPGVGSAA VAPGLGTECA RCRARTSAAY
SLLRELQAEP GLPGAAARKV RDWLCAVEGE RSALSSASGP DSGIESAPAD DQAAQGTSGR
KGDEGAQQLL ILQSQVARLE EENRDFLAAL EDAMEQYKLQ SDRLREQQEE MVELRLRLEL
AQPGWGAPGL LQGLSPGSFV PRPHTAPLGG AHTHMTGTMP RTCLPGEEVS SEQQVANGKE
AKAELLAQVD KLGSASSTTS EEEEEEEEEP PRRTLHLRRN GISNWSQRAG VRPGSPPDRK
GPEVCPEEPA AAIPAPQAVG GSKAPGQTRQ APAAMASEWR LAQAQQKIRE LAINIRMKEE
LIGELVRTGK AAQALNRQHS QRIRELEQEA ERVRGELCEG QRQLRELEGR EPQDASERSR
LQEFRKRVAA AQSQVQVLRE KKQATERLVS LSAQSETRLQ ELERNVQLMR RQQGQLQRRL
REETEQKRRL ETEMNKRQHR VKELELKHEQ QQKILKIKTE EIAAFQRNRR SGSNGSVVSL
EQQQKIEEQK KWLDQEMEKV LQQRRALEEL GEELRKREVI LAKKEALMQE KTGLESKRMR
SSQALNEDIV RVSSRLEHLE KELSEKSGQL RQGSALNQQQ IRGEIDTLRQ EKDSLLKQRL
EIDSKLRQGS LLSPEEERTL FQLDEAIEAL DAAIEYKNEA ITCRQRVLRA SASLLSQCEM
NLMAKLSYLS SSETRALLCK YFDKVVTLRE EQHQQQIAFS ELEMQLEEQQ RLVYWLEVAL
ERQRLEMDRQ LTLQQKEHEQ NVQLLLQQGR DHLGEGLADS KRQYEARIQA LEKELGRHMW
INQELKQKLS AGNTAGQSRG CERRSHCLEN RQGLGNEDGP HVAAQEPLWP SSLLEGAPRV
WDESRDLVHA PLPLTWKRSS LCSEQGSSEE PRARETTEPP VGRVLPMGEV SLSWNFGPLP
KPRWEPRRTS PGMIDVRKNP L
//
