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Database: UniProt
Entry: D4ABY6_RAT
LinkDB: D4ABY6_RAT
Original site: D4ABY6_RAT 
ID   D4ABY6_RAT              Unreviewed;       548 AA.
AC   D4ABY6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   20-JUN-2018, entry version 64.
DE   SubName: Full=RCG21617, isoform CRA_a {ECO:0000313|EMBL:EDM13714.1};
DE   SubName: Full=SH2B adapter protein 3 {ECO:0000313|Ensembl:ENSRNOP00000038125};
DE   SubName: Full=SH2B adaptor protein 3 {ECO:0000313|EMBL:AFP87272.1};
GN   Name=Sh2b3 {ECO:0000313|Ensembl:ENSRNOP00000038125};
GN   ORFNames=rCG_21617 {ECO:0000313|EMBL:EDM13714.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AFP87272.1};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000038125, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000038125,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:EDM13714.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM13714.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [3] {ECO:0000313|EMBL:EDM13714.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDM13714.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [5] {ECO:0000313|EMBL:AFP87272.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SS/JrHsd/Mcwi {ECO:0000313|EMBL:AFP87272.1};
RA   Flister M.J., Hoffman M.J., Prisco S.Z., Sarkis A.B., Lazar J.,
RA   Moreno-Quinn C., Jacob H.J.;
RT   "Role of SH2B3 in Chronic Inflammation and Remodeling.";
RL   Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|Ensembl:ENSRNOP00000038125}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000038125};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
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DR   EMBL; AABR07036365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JX215366; AFP87272.1; -; mRNA.
DR   EMBL; CH473973; EDM13714.1; -; Genomic_DNA.
DR   EMBL; CH473973; EDM13716.1; -; Genomic_DNA.
DR   UniGene; Rn.11228; -.
DR   Ensembl; ENSRNOT00000030583; ENSRNOP00000038125; ENSRNOG00000028198.
DR   RGD; 68411; Sh2b3.
DR   GeneTree; ENSGT00530000063355; -.
DR   OMA; PHWDSEL; -.
DR   OrthoDB; EOG091G04RI; -.
DR   TreeFam; TF323184; -.
DR   Reactome; R-RNO-1433559; Regulation of KIT signaling.
DR   Reactome; R-RNO-983231; Factors involved in megakaryocyte development and platelet production.
DR   Proteomes; UP000002494; Chromosome 12.
DR   Bgee; ENSRNOG00000028198; -.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:Ensembl.
DR   GO; GO:0035162; P:embryonic hemopoiesis; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR   CDD; cd10412; SH2_SH2B3; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015012; Phe_ZIP.
DR   InterPro; IPR036290; Phe_ZIP_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR030523; SH2B.
DR   InterPro; IPR030522; SH2B3.
DR   InterPro; IPR035059; SH2B3_SH2.
DR   PANTHER; PTHR10872; PTHR10872; 1.
DR   PANTHER; PTHR10872:SF1; PTHR10872:SF1; 1.
DR   Pfam; PF08916; Phe_ZIP; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF109805; SSF109805; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN      336    434       SH2. {ECO:0000259|PROSITE:PS50001}.
SQ   SEQUENCE   548 AA;  60385 MW;  83E7B96F338552B3 CRC64;
     MNEPTVQPSR TSSAPASPAS PRGWSDFCER HAAAAARDLA RQYWLFARAH PQPPRADLVS
     LQFAELFQRH FCREVREGLA GPPGHDYRAT APPRPALPKA RSSEDLGPRP SCALQHLRRG
     LRQLFRRRSA GELPGATSDT NDTDAIATTR PGPARKLLPW SLREPSAEAL KEVVLRYSLA
     DEAAMDSGAH WQRGRLVLRS PGPGHGHLLQ LFDPPKSSKP KLQEACSSIQ EVRPCTRLEM
     PDNLYTFVLK VQGQTDIIFE VGDEQQLNSW LAELRASTGL GLEHLDTELP LSLVAEPGPA
     ISPRGSTDSL DQGASPGVML DPACQKTDHF LSCYPWFHGP ISRVRAAQLV QLQGPDAHGV
     FLVRQSESRR GEYVLTFNLQ GRAKHLRLVL TERGQCRVQH LHFPSVVDML RHFQRSPIPL
     ECGAACDVRL SGYVVVVSQA PGSSNTVLFP FSLPHWDSEL GHPHLSSAGC PPGHGAEALR
     GQVTPPEQIF HLVPSPEELA NSLRQLELES VSSARDSDYE MDSSSRSHLR AIDNQYTPLS
     QLCREANL
//
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