ID D4AEC7_RAT Unreviewed; 801 AA.
AC D4AEC7;
DT 20-APR-2010, integrated into UniProtKB/TrEMBL.
DT 20-APR-2010, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=SET and MYND domain-containing protein 4 {ECO:0000256|ARBA:ARBA00026173};
GN Name=Smyd4 {ECO:0000313|Ensembl:ENSRNOP00000029945.4,
GN ECO:0000313|RGD:1307369};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000029945.4, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000029945.4, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000029945.4,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000029945.4}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000029945.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; NP_001099280.1; NM_001105810.1.
DR RefSeq; XP_006246736.1; XM_006246674.3.
DR AlphaFoldDB; D4AEC7; -.
DR SMR; D4AEC7; -.
DR STRING; 10116.ENSRNOP00000029945; -.
DR PhosphoSitePlus; D4AEC7; -.
DR PaxDb; 10116-ENSRNOP00000029945; -.
DR Ensembl; ENSRNOT00000029866.6; ENSRNOP00000029945.4; ENSRNOG00000026783.6.
DR GeneID; 287525; -.
DR KEGG; rno:287525; -.
DR AGR; RGD:1307369; -.
DR CTD; 114826; -.
DR RGD; 1307369; Smyd4.
DR eggNOG; KOG2084; Eukaryota.
DR GeneTree; ENSGT00730000111079; -.
DR HOGENOM; CLU_021727_0_0_1; -.
DR OMA; FDCTCPA; -.
DR OrthoDB; 7525at2759; -.
DR TreeFam; TF106441; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000026783; Expressed in skeletal muscle tissue and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR CDD; cd10536; SET_SMYD4; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044421; SMYD4_SET.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR46165; SET AND MYND DOMAIN-CONTAINING PROTEIN 4; 1.
DR PANTHER; PTHR46165:SF2; SET AND MYND DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SUPFAM; SSF144232; HIT/MYND zinc finger-like; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 801 AA; 88953 MW; 8F68F0F519F8AF8F CRC64;
MDLPVDEWKS YLLEKWALLP KSVQVTISTA ETLSDIFLHS SSLLQPEDEM FLKQLSSSCS
VEKDSGAPLF YREEGNKRFQ EKEYMGAAVL YSKGVSHSRP NTEDISLCYA NRSAALFHLG
QHEACLKDIV RAGMHGYPER LQPKLMIRKT ECLVNLGRLQ EARQTISDLE NSLTTKPTLM
PSSHQILQRN VQQLKMKIQE KETLPESFPA ALTKALEDMA LGEENKQISG ASLSVSLCTD
PLKGRHLVAT KDILPGELLV KEDAFVSVLN PGEMPPLRHC LENKWDTRVT SADLYCHRCL
RHTLATVPCG GCSYAKYCSQ ECVQQAWDHY HSTECSLGGL LLTLGVFCHV ALRMTLLARF
EDVDRVIRMI CDKTGRKDTC LPESKDLVKT FGYTNQGESE ENSETCEPSI PGCNVNGKYE
NNYDAVLSLL PHTEKHSPEH KFICAVSVSA LCRQLKATSL QAQTTGLKSP RLKAVTPGLC
TDLTVWGVAM LQHMLQLQCN AQAITSICYA GSKESIITNS RQVRLATGVF PVVSLLNHSC
SPNTSVSFTS TVATIRAAQQ IAKGQEILHC YGPHESRMGV AERQQRLSSQ YFFDCSCPAC
HAETLRAAVA PRWEAFCCNT CRVPMQGNDV LSCSNESCTN SVSRDRLVSR LQDLQQQVHT
AQKLLRSDRP EQAIQQLLEC QRAAENFLSA EHTVLGEIED GLAQAYATLG DWRQSAAHVQ
KSLQVVEARH GPSSVEIGHE LFKLAQVLFN GLAVPEALDA IWKAEKILLV HCGPESDEVQ
ELREMRSCLL DSSFTPVRPL V
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