ID D4AIV4_ARTBC Unreviewed; 508 AA.
AC D4AIV4;
DT 18-MAY-2010, integrated into UniProtKB/TrEMBL.
DT 18-MAY-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=FMN dependent dehydrogenase, putative {ECO:0000313|EMBL:EFE36677.1};
GN ORFNames=ARB_04202 {ECO:0000313|EMBL:EFE36677.1};
OS Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS mentagrophytes).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX NCBI_TaxID=663331 {ECO:0000313|EMBL:EFE36677.1, ECO:0000313|Proteomes:UP000008866};
RN [1] {ECO:0000313|Proteomes:UP000008866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4681 / CBS 112371 {ECO:0000313|Proteomes:UP000008866};
RX PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT "Comparative and functional genomics provide insights into the
RT pathogenicity of dermatophytic fungi.";
RL Genome Biol. 12:R7.1-R7.16(2011).
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFE36677.1}.
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DR EMBL; ABSU01000001; EFE36677.1; -; Genomic_DNA.
DR RefSeq; XP_003017322.1; XM_003017276.1.
DR AlphaFoldDB; D4AIV4; -.
DR STRING; 663331.D4AIV4; -.
DR GeneID; 9524431; -.
DR KEGG; abe:ARB_04202; -.
DR eggNOG; KOG0537; Eukaryota.
DR eggNOG; KOG0538; Eukaryota.
DR HOGENOM; CLU_020639_1_1_1; -.
DR OMA; WSYVAGG; -.
DR OrthoDB; 1887365at2759; -.
DR Proteomes; UP000008866; Unassembled WGS sequence.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd02922; FCB2_FMN; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR018506; Cyt_B5_heme-BS.
DR InterPro; IPR000262; FMN-dep_DH.
DR InterPro; IPR037396; FMN_HAD.
DR InterPro; IPR037458; L-MDH/L-LDH_FMN-bd.
DR PANTHER; PTHR10578:SF82; CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED; 1.
DR PANTHER; PTHR10578; S -2-HYDROXY-ACID OXIDASE-RELATED; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF01070; FMN_dh; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR PROSITE; PS00191; CYTOCHROME_B5_1; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
DR PROSITE; PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PE 4: Predicted;
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000008866}.
FT DOMAIN 4..96
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT DOMAIN 118..486
FT /note="FMN hydroxy acid dehydrogenase"
FT /evidence="ECO:0000259|PROSITE:PS51349"
SQ SEQUENCE 508 AA; 54743 MW; A04593776D2F88B8 CRC64;
MASSRMIDAE EVAKHNKTDS CWVVLYGKVY DLVGAEVKYS SSHDVNVTNF LPNHPGGANI
ILQLAGRDAT EEYDPIHPTG TLEDSLPPEA LVGRVDEKSL VKLAPKPAKA EKTTEGPPPL
STLLNMDDFE AAASKQLTHK AWAYYFSGAD DLISKSLNNS IYRSILLRPR VFVDCKNCSL
ATSMLGYKLN TPIIASPTAM ARLAHPSGEA GIAAACAKFG AMQIISNNAS MTPEEIVKGA
PPDQVFGWQL YVQIERKKSE AMLARINKLK AIKFICLTLD APVPGKRELD ERTKVIADTP
AVADIVKSSG GHEIAGGSGL GQQLFAGTDP SLTWKDTLPW LLKHTDLPIV LKGIQTHEDA
YIASLHTPQI KGIILSNHGG RAMDTAPPSI HTLMEIRKYC PEVFNRIEVW IDGGIKRGTD
VVKALCLGAK GVGVGRNALF SLAAGGPEGV ERMLEILCAE TMTAMRLLGV DKVEDLGMQH
INARAVEQQL YDGGAGLDIL GSHIKAKI
//
